No abstract available.
Child* ; Humans

Nevus flammeus is benign but cosmetically devastating congenital vascular malformation whose past treaments have been marred by unacceptable complication or by unacceptable ineffectiveness. Argon laser is a therapeutic device which has been newly applied to this condition with fairly good result. However, all lesions do not show good response and it depends on the clinical and histopathological types. Therefore, it is very important to select patients who will show good response to argon laser therapy. Histological pattern was indicated as the most important prognostic factor. However, it is not always possible to get the histological data. This study was undertaken to evaluate whether it is possible to anticipate histologic patterns of nevus flammeus from color and clinical morphology of the lesions when biopsy is difficult to be taken. Color and clinical morphology of the lesions were recorded, and 4-mm punch biopsies were performed in 74 patients who visited the Laser Clinic in our dermatologic department during past 2 years, The study results were as follows. Eleven pink cases were all patch form morphologically but 8 cases(72, 7%) were constricted type and 8 cases(27 Q%) were intermediate type histopathologically. In 28 red cases, 27 cases(96 4gp) were patch form and only 1 case was smooth elevated form morphologically. And 2p cases(74, l%) were dilated or intermediate type and 7 cases(25 9%) were constricted or deep located type histologically.
Argon ; Biopsy ; Humans ; Laser Therapy ; Nevus* ; Port-Wine Stain* ; Vascular Malformations

Statisticsl observation was made on 404 patients who had been referred for consultation to the Department of Dermatology during their admission in Seoul National University Children's Hospital from October 1985 to March 1987. The results were as follows : 1. The consulted pstients were 404 among 126,622 inpatients(0.32%). 2. The most frequent age group was below 1 year(25.0%). 3. Pediatrics was the most importnat department in the number, as well as in the rate of consulted patients to inpatients. 4. The most common 10 dermatoses were contact dermatitis, atopic dermatitis, drug eruption, fungal infection, viral infection, infantile eczema, benign tumor, miliaria, urticaria, and skin manifestation of systemic diseases in order of frequency. 5. The frequent causes of consultation were as follows ; the dermatologic diseases or conditions 67.6%, the diseases related to the trestment 13.4%, the skin lesions of systemic diseases 10.8%, the dermatologic tests 3.6%, and admitted to other departments with dermatologic diseases 1.2% respectively.
Dermatitis, Atopic ; Dermatitis, Contact ; Dermatology* ; Drug Eruptions ; Humans ; Inpatients* ; Miliaria ; Pediatrics ; Seoul ; Skin ; Skin Diseases ; Skin Manifestations ; Urticaria

No abstract available.

Although port-wine stains present as macular patches generally, some patients show considerable overgrowth of angiomatous tissue and show different results of laser therapy according to their histologic patterns. We observed 337 port-wine stain patients clinically, and tried to classify clinical morphology of port-wine stains and analyze with other features such as color, age and size. The results were as follows: Most of the lesions were located on the face, followed by neck, upper extremity, lower extremity and trunk in order. 2, On the face, the left lower part was the most frequent area of the lesions. The difference of the distribution between right and left side was not found, but the lesions were significantly more frequent on the lower part than the upper one. 3. The morphology was classified into patch, hypertrophic, cavernous and papular form according to therapeutic purpose. 4 When the color is darker, the others than the patch form appeared. 5, In old patients the color was darker and the papular form increased. 6. When the size enlarged, the hypertrophic form. increased. 7. Among ten patients who got the lesions at both the upper and lower eyelids, two showed ocular problems.
Coloring Agents* ; Eyelids ; Humans ; Laser Therapy ; Lower Extremity ; Neck ; Port-Wine Stain ; Upper Extremity ; Wine*

No abstract available.
Humans

The argon laser has been used in the treatment of a variety of cutaneous vascular and pigmented lesions. In 1983, authors reported on the therapeutic effect from argon laser treatment of nevus flammeus. This study was undertaken to evaluate the therapeutic effect and complication of the argon laser on many cutaneous lesions except nevus flammeus. The data of the 67 patients who were treated between November, 1984 and March, 1986 and could be followed up over 3 months at the Department of Dermatology, Seoul National University Hospital were analyzed. Patients were treated with Coherent Radiation Model No. 920 Laser with a spot size of 1 mm in diatemer. The pawer ranges were between 1.6 and 2.6 W using pulsed wave or continuous wave according to the size and the shape of the lesions. The argon laser is an effective modality in the treatment of superficial vascular lesions and especially when telangiectasia is prominent. In pigmented lesions, argon laser is effective for pigmented nevi excluding intradermal nevi and has been found effective in small sized nevus spilus and lentigines.
Argon* ; Dermatology* ; Humans ; Lentigo ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented ; Port-Wine Stain ; Seoul ; Telangiectasis

No abstract available.
Urinary Bladder*

Allergic contact dermatitis is a prototype of delayed hypersensitivity reaction. Langerhans cells, keratinocytes and T lyrnphocytes play major roles in the pathogenesis of allergic contact dermatitis. We observed Langerhans cells and keratinocytes in contact sensitized epidermal sheets of mice and performed mixed epidermal cell lymphocytes reaction with normal epidermal cells and contact sensitized epidermal cells to determine the lymphocyte stimulating capacity of contact sensitized epidermal cell. We obtained following results : 1. The Langerhans cells were decreased in number and morphologically damaged in contact sensitized epidermis. 2. Ia antigen expression on keratinocytes was detected in almost all contact sensitized epidermal sheets. 3. The allogeneic lymphocyte stimulating capacity of contact sensitized epidermal cells was greater than that of normal epidermal cells. 4. The allogeneic lymphocyte stimulating capacity of contact sensitized epiderrnal cells was lost after treatment of epidermal cells with anti Ia antibody and complement. From these results, it is conceivable that the contact sensitized epidermal cells can amplify the immune reactions by stimulating the lynphocytes which are infiltrated in contact sensitized epidermis.
Animals ; Complement System Proteins ; Dermatitis, Allergic Contact ; Epidermis ; Histocompatibility Antigens Class II ; Hypersensitivity, Delayed ; Keratinocytes ; Langerhans Cells ; Lymphocytes ; Mice*

No abstract available.