No abstract available.

The Pill Questionnaire (PillQ) has been proposed as a simple way to evaluate cognitive deficits and their impact on the daily lives of those with Parkinson’s disease (PD) by asking patients or caregivers about whether patients can independently manage their pills. We used the PillQ to investigate the association of ability to manage medication with cognition and activities of daily living (ADLs) in patients with PD. Patients were divided into two groups based on PillQ scores. The no-impact group was able to take their antiparkinsonian medication independently, and the impact group exhibited problems describing their treatment or taking their drugs independently. A total of 208 participants (93 men) were included. 111 patients (53.4%) were included in the no-impact group, and 97 (46.6%) were included in the impact group. The impact group showed significantly lower cognitive functioning, difficulties with the performance of ADLs, and severe motor dysfunction. PillQ scores were significantly correlated with Mini-Mental State Examination and the Montreal Cognitive Assessment, and Clinical Dementia Rating scores. Management of medication by PD patients is associated with cognitive function, and the PillQ is an easy and useful test for detecting cognitive impairment and its impact on daily life.

No abstract available.
Sinusitis*

BACKGROUND: Because Chlamydia trachomatis infection is the most frequent etiological agent in sexually transmitted diseases, accurate diagnostic methods are essential. The enzyme-linked fluorescence assay and Papanicolaou smear were evaluated for detection of C. trachomatis in patients with vaginitis. METHODS: Endocervical swabs from 78 women with symptoms of vaginal discharge, itching or lower abdominal pain in the obstetrics/gynecology department of Gyeongsang National University Hospital were tested by Vidas Chlamydia assay. Slides were stained with Papanicolaou and Giemsa stain to demonstrate inclusion body. RESULTS: Five (6.4%) of 78 endocervical specimens were positive by Vidas Chlamydia assay. Only one case was positve for C. trachomatis with Papanicolaou stain. We could not detect any C. trachomatis by Giemsa stain. CONCLUSION: The Vidas Chlamydia test allows sensitive and high-volume testing for chlamydiae and could be useful for the diagnosis of infection with C. trachomatis in patients with vaginitis and pelvic inflammatory disease.
Abdominal Pain ; Azure Stains ; Chlamydia trachomatis* ; Chlamydia* ; Diagnosis ; Female ; Fluorescence ; Humans ; Inclusion Bodies ; Papanicolaou Test ; Pelvic Inflammatory Disease ; Pruritus ; Sexually Transmitted Diseases ; Vaginal Discharge ; Vaginitis

PURPOSE: We report a case of acute dacryocystitis diagnosed with abscess and rupture of lacrimal sac and fistula to posterior orbit during the operation. CASE SUMMARY: A 71-year-old woman visited our clinic with edema and pain in the eyelid from three days ago. For past four months, there was viscous of the left eye and tears. The patient had severe conjunctival chemosis and hyperemia, compared with the left eyelid edema and redness. Orbital CT scan showed orbital cellulitis, which was followed by systemic antibiotics and steroid therapy. On the 4th day of therapy, orbital abscess formation was observed in orbit MRI and surgical drainage was planned. During surgery, we found rupture of the posterior part of lacrimal sac and fistula to posterior orbit. Pseudomonas aeruginosa was identified in the bacterial cultures, and after the administration of appropriate antibiotics, the disease showed improved progress, and then additional dacryocystorhinostomy was performed. CONCLUSIONS: In our case, acute dacryocystitis rarely spread in orbit, which may lead to delayed diagnosis, orbital cellulitis and abscess, resulting in serious complications of vision threat. So, we think that it is necessary to consider surgical treatment more actively in the stage of chronic dacryocysitis.
Abscess ; Aged ; Anti-Bacterial Agents ; Dacryocystitis ; Dacryocystorhinostomy ; Delayed Diagnosis ; Drainage ; Edema ; Eyelids ; Female ; Fistula ; Humans ; Hyperemia ; Magnetic Resonance Imaging ; Nasolacrimal Duct ; Orbit ; Orbital Cellulitis ; Pseudomonas aeruginosa ; Rupture ; Tears ; Tomography, X-Ray Computed

No abstract available.
Ureter* ; Vesico-Ureteral Reflux*

Because castration-resistant prostate cancer (CRPC) does not respond to androgen deprivation therapy and has a very poor prognosis, it is critical to identify a prognostic indicator for predicting high-risk patients who will develop CRPC. Here, we report a dataset of whole genomes from four pairs of primary prostate cancer (PC) and CRPC samples. The analysis of the paired PC and CRPC samples in the whole-genome data showed that the average number of somatic mutations per patients was 7,927 in CRPC tissues compared with primary PC tissues (range, 1,691 to 21,705). Our whole-genome sequencing data of primary PC and CRPC may be useful for understanding the genomic changes and molecular mechanisms that occur during the progression from PC to CRPC.
Dataset ; Genome ; Humans ; Prognosis ; Prostate* ; Prostatic Neoplasms*

Metastasis to the skin occurs rarely in gynecologic cancer. Although carcinoma of the cervix is the fifth most common malignancy in Korean women, cutaneous involvement originating from cervical cancer is unusual. Common pattern of occurrence is multiple nodule in abdomen, vulva, lower extremities. We report a case of metastasis from squamous cell carcinoma of cervix to vulva. The patient was diagnosed with cervical cancer IIA. The extensive skin lesion on the vulva occurred 3 months after neoadjuvant chemotherapy, radical hysterectomy and concurrent chemoradiation. We have experienced such a case and report the case with brief review of literatures.
Abdomen ; Carcinoma, Squamous Cell ; Cervix Uteri ; Female ; Humans ; Hysterectomy ; Lower Extremity ; Neoplasm Metastasis ; Skin ; Uterine Cervical Neoplasms ; Vulva

PURPOSE: To predict pulmonary arterial hypertension by comparing the extent of honeycombing lesion with the diameter of main pulmonary artery (MPA). MATERIALS AND METHODS: We retrospectively reviewed 21 patients (20 men, one woman) who showed honeycombing lesion on HRCT, and also analysized a control group of 30 (29men, one woman) who had no cardiopulmonary symptom and no abnormality on chest CT. On Chest HRCT, we scanned at four levels [1)aortic arch, 2) bifurcation of bronchus, 3) mid-portion of left ventricle, 4) dome of right diaphragm], and two radiologists then evaluated the proportion of honeycombing lesion within the entire lung field. According to the extent of this, we divided the patients into five groups [<20% (I), 20-39% (II), 40-59% (III), 60-79% (IV), > or = 80% (V)], and then divided Group I into two subgroups [<10 % (I|1), 10-19% (I-2)]. Using contrast-enhanced routine CT, the main pulmonary artery (MPA) was measured at its the widest diameter perpendicular to the long axisat the level of its bifurcation. RESULT: In group I (n=11) MPA was 28.4+/-2.6mm ; in group II (n=6), it was31.7+/-2.0mm ; in group III (n=2), 33.5mm ; in group IV (n=1), 33mm ; and in group V (n = 1), 39mm. In subgroup I-1MPA was 26.1+/-1.9mm, and in subgroup I-2, it was 29.8+/-1.6mm. In the control group, MPA was 25.1+/- 2.0mm. CONCLUSION: The extent of honeycombing lesion is closely related to the change in diameter of the MPA. Honeycombing lesion extending over more than 10% of the lung field may lead to pulmonary arterial hypertension.
Bronchi ; Heart Ventricles ; Humans ; Hypertension ; Hypertension, Pulmonary ; Lung ; Pulmonary Artery* ; Retrospective Studies ; Thorax ; Tomography, X-Ray Computed

Sporadic spastic paraplegia (SSP) and hereditary spastic paraplegia (HSP) belong to a clinical and genetically heterogeneous group of disorders characterized by progressive spasticity and weakness in the lower extremities. The symptoms are associated with pyramidal tract dysfunction and degeneration of the corticospinal tracts. Parkinsonism is uncommon in SSP/HSP patients. However, both disorders are associated with damage to the nigrostriatal dopaminergic system. In the present study, the clinical features of patients with SSP/HSP were investigated, and nigrostriatal dopaminergic binding potential was assessed using dopamine transporter (DAT) single-photon emission computer tomography (SPECT). Nine patients with spastic paraplegia participated in the present study. The subjects underwent DAT SPECT using the agent [2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3,2,1]oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiolato (3-)-N2,N20,S2,S20]oxo-[IR-(exo-exo)])-[99mTc]technetium ([99mTc]TRODAT-1). The [99mTc]TRODAT-1 SPECT images of five patients appeared normal, whereas the images of four patients revealed reduced striatal ligand uptake. Among the four patients with reduced uptake, two had parkinsonism, and one exhibited periodic limb movements and restless leg syndrome. Our DAT SPECT imaging study shows that reduced DAT density may be observed in patients with parkinsonism. The results of the present study offer an explanation for the spectrum of spastic paraplegia symptoms and the progression of the disorder.
Adult ; Aged ; Brain/*radionuclide imaging ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Female ; Humans ; Male ; Middle Aged ; Organotechnetium Compounds/diagnostic use ; Paraplegia/diagnosis/genetics/*radionuclide imaging ; Parkinsonian Disorders/complications/genetics/*radionuclide imaging ; Pyramidal Tracts ; Radiopharmaceuticals/diagnostic use ; Spastic Paraplegia, Hereditary/diagnosis/genetics/*radionuclide imaging ; Tomography, Emission-Computed, Single-Photon