A case of Down's syndrome in which transient myeloproliferative disorder developed is described. In hematologic findings of peripheral blood, high blast cell count on 1st day of birth had been found and after serial follow-up for several weeks, decrease in WBC counts from 22.6x10(9)/L to 7.5x10(9)/L and blast cell counts from 31% to 2% occurred. The karyotype of his patient was 45,XY, der (13;14) (q10;q10), der(14;21) (q10;q10), +21. Karyotyping of his father revealed 45,XY, der(13;14) (q10;q10). Without specific chemotherapy, hematologic and clinical recovery was occurred within several weeks. We deport a case of transient myeloproliferative disorder in Robertsonian translocatlon type of Down's syndrome accompanying another Robertsonian translocation, der (13;14) (q10;q10), inherited from his father.
Cell Count ; Down Syndrome ; Drug Therapy ; Fathers ; Follow-Up Studies ; Humans ; Karyotype ; Karyotyping ; Myeloproliferative Disorders* ; Parturition

No abstract available.
Animals ; Chorionic Gonadotropin* ; Humans* ; Mice* ; Uterus*

OBJECTIVES: The purpose of this study was to determine the clinical significance of residual amniotic fluid volume, as measured by the amniotic fluid index(AFI), on the prediction of latency period and perinatal outcomes in patients with preterm premature rupture of the membranes(PPROM). METHODS: Study population consisted of 103 singleton pregnancies with PPROM between 24 and 34 weeks' gestation. Amniotic fluid index was determined using transabdominal ultrasound at admission. Latency period was defined as time interval in hours between admission and delivery. All medical records of mothers and neonates were reviewed. Spearman's rho rank correlation, receiver-operator characteristic(ROC) curve analysis, survival analysis and Cox's proportional hazard model were used for statistical analysis. RESULTS: There was a statistically significant correlation between latency period and AFI at admission. ROC curve analysis showed that AFI at admission had a significant predictive value in the prediction of latency period < 48 hours. Survival analysis demonstrated that AFI < 5.0 was strongly associated with the likelihood of shorter latency period, Cox's proportional hazard model indicated that AFI < 5.0 was a significant independent predictor for the occurrence of latency period < 48 hours even after adjustment of other independent variables. The patients with AFI <5.0 had a higher rate of cesarean section due to fetal distress than those with AFI > 5.0 but the incidence of chorioamnionitis was not significantly different between two groups. Comparing the perinatal mortality and neonatal morbidity including infectious morbidity between the neonates born to mothers with AFI <5.0 and those with AFI > 5.0, there was no significance after adjustment of gestational age at birth. CONCLUSION: AFI at admission has a significant correlation with latency period and predictive value in prediction of latency period in the patients with PPROM. AFI <5.0 is a independent predictor for the shorter latency period.
Amniotic Fluid* ; Cesarean Section ; Chorioamnionitis ; Female ; Fetal Distress ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Latency Period (Psychology)* ; Medical Records ; Membranes* ; Mothers ; Parturition ; Perinatal Mortality ; Pregnancy ; Proportional Hazards Models ; ROC Curve ; Rupture* ; Ultrasonography

PURPOSE: The aim of the study was to evaluate the effect of abutment shade, ceramic thickness, and coping type on the final shade of zirconia all-ceramic restorations. MATERIALS AND METHODS: Three different types of disk-shaped zirconia coping specimens (Lava, Cercon, Zirkonzahn: o10 mm x 0.4 mm) were fabricated and veneered with IPS e.max Press Ceram (shade A2), for total thicknesses of 1 and 1.5 mm. A total of sixty zirconia restoration specimens were divided into six groups based on their coping types and thicknesses. The abutment specimens (o10 mm x 7 mm) were prepared with gold alloy, base metal (nickel-chromium) alloy, and four different shades (A1, A2, A3, A4) of composite resins. The average L*, a*, b* values of the zirconia specimens on the six abutment specimens were measured with a dental colorimeter, and the statistical significance in the effects of three variables was analyzed by using repeated measures analysis of variance (alpha=.05).The average shade difference (DeltaE) values of the zirconia specimens between the A2 composite resin abutment and other abutments were also evaluated. RESULTS: The effects of zirconia specimen thickness (P<.001), abutment shade (P<.001), and type of zirconia copings (P<.003) on the final shade of the zirconia restorations were significant. The average DeltaE value of Lava specimens (1 mm) between the A2 composite resin and gold alloy abutments was higher (close to the acceptability threshold of 5.5 DeltaE) than th ose between the A2 composite resin and other abutments. CONCLUSION: This in-vitro study demonstrated that abutment shade, ceramic thickness, and coping type affected the resulting shade of zirconia restorations.
Alloys ; Ceramics* ; Composite Resins ; Masks*

No abstract available.
Fibromatosis, Gingival* ; Mandible*

No abstract available.
Fibromatosis, Gingival* ; Mandible*

BACKGROUND: Follicular dendritic cells (FDCs) play key roles during T cell-dependent humoral immune responses by allowing antigen-specific B cells to survive, proliferate, and differentiate within the FDC networks of secondary follicles, i.e., germinal centers (GC). METHODS: A novel monoclonal antibody, 3C8, was generated by immunizing with an FDC line HK, in order to understand the molecular signals involved in the FDC-B cell interactions in the microenvironment of the GC. RESULTS: The 3C8 antibody did not bind to mononuclear cells, including T cells, B cells, and monocytes. Murine L929 and human skin fibroblasts exhibited no or little reactivity to 3C8. However, 3C8 specifically recognized HK cells by flowcytometry. Furthermore, the antigen recognized by 3C8 was restricted to the GC of the human tonsil. Dendritic networks of the GC were intensely stained by 3C8, but cells out side the GC were not. CONCLUSION: Our result s suggest that the antigen 3C8 may play some unique role on FDCs during the GC reactions.
B-Lymphocytes ; Cell Communication ; Dendritic Cells, Follicular* ; Fibroblasts ; Germinal Center ; Humans ; Immunity, Humoral ; Monocytes ; Palatine Tonsil ; Skin ; T-Lymphocytes

No abstract available.
Aeromonas hydrophila* ; Aeromonas* ; Animals ; Histamine Release* ; Histamine* ; Mast Cells* ; Rats*

Tethered cord syndrome is a type of spinal dysraphism with a low-lying conus, which is frequently associated with an intraspinal lipoma, diastematomyelia, or fibrous band. The clinical manifestations include spine abnormalities such as the spina bifida or various neurological symptoms involving lower extremities and sphincters. However, the spinal roots are often injured during the detethering procedures which clinically results in a neurological deficit. The continuity of spinal roots should be monitored during detethering surgery for the tethered spinal cord because neural elements are embedded in lipoma or anomalous tissues. Evoked muscle action potentials indicate only motor function, therefore, it is more appropriate to record somatosensory evoked potentials across the operative field at the same time. We used a combined technique of tibial nerve somatosensory evoked potential and compound muscle action potentials stimulated in the spinal roots directly for an intraoperative monitoring during the untethering procedure. We reported good results from three patients with tethered cord syndrome who had taken the intraoperative monitoring during the untethering surgery. We suggest that intraoperative monitoring can prevent the unwanted injury to the neural tissue in the level of the tethering during the detethering surgery.
Action Potentials ; Conus Snail ; Evoked Potentials, Motor* ; Evoked Potentials, Somatosensory* ; Humans ; Lipoma ; Lower Extremity ; Monitoring, Intraoperative* ; Neural Tube Defects* ; Spinal Cord ; Spinal Dysraphism ; Spinal Nerve Roots ; Spine ; Tibial Nerve

Electrophysiologic monitoring during surgery for the spinal cord tumor is necessary for identification of the nerve root, prevention of the nerve injury, and prediction of postoperative prognosis. In other countries, intraoperative electrophysiologic monitorings are commonly done in various cases such as selective posterior rhizotomy, scoliosis, sponlylolisthesis, lipomeningocele, and spinal cord tumor, but it is not a common procedure in Korea except for the selective posterior rhizotomy. We report 3 cases of electrophysiologic monitoring during sugery for the spinal cord tumor at lower thoracic level. Using multichannel EMG machine, we recorded free-run EMG, somatosensory evoked potential(SSEP) of tibial nerve, and compound motor unit action potential (CMAP) of various regions such as abdomen, lower extremity, and anus, stimulating nerve roots at the lower thoracic level. We identified CMAP from rectus abdominis muscles only in the first case, but in the second case, we identified CMAP from tibialis anterior and gastrocnemius muscles which avoided the injury to lumbosacral roots. In the third case, SSEP improved immediately after we removed the mass at lower thoracic level. We concluded that intraoperative electrophysiologic monitoring combined with recording CMAP is a useful procedure to minimize neural tissue damage during surgery for the spinal cord tumor at lower thoracic level.
Abdomen ; Action Potentials ; Anal Canal ; Korea ; Lower Extremity ; Muscles ; Prognosis ; Rectus Abdominis ; Rhizotomy ; Scoliosis ; Spinal Cord Neoplasms ; Tibial Nerve