No abstract available.
Hamartoma*

No abstract available.
Doxycycline*

Neck circumference is associated with a distinctive fat storage process that confers additional metabolic risk. Hence, this study aimed to investigate the correlation between baseline neck circumference and the incidence of cerebrovascular disease using a prospective community-based sample of Korean adults over 12 years of follow-up, after controlling for selected covariates. Methods: Participants with non-cerebrovascular disease were divided into 4 groups (Q1–Q4) based on their baseline neck circumference. Cox proportional hazards analysis was used to calculate hazard ratios and 95% confidence intervals (CIs) to evaluate the relationship between neck circumference and cerebrovascular disease incidence over a 12-year period. Results: Among this study’s 3,662 participants, 128 (3.50%) developed cerebrovascular disease. The incidence of cerebrovascular disease increased from 2.2% in Q1 to 4.3% in Q2, 2.5% in Q3, and 5.0% in Q4. When compared to Q1, the relative risks of cerebrovascular disease development were 0.57 (95% CI, 0.25–1.31), 0.86 (95% CI, 0.38–1.96), and 0.79 (95% CI, 0.30–2.07) in man and 1.86 (95% CI, 0.66–5.20), 3.50 (95% CI, 1.25–9.86), and 4.71 (95% CI, 1.50–14.77) in woman in Q2, Q3, and Q4, respectively, after adjusting for most risk factors related to cerebrovascular disease. Conclusion: The relationship between neck circumference and cerebrovascular disease was stronger in woman than in man, indicating potential differences between the sexes. These results are meaningful for evaluating and surveilling neck circumference as a promising tool for identifying subgroups of vulnerable and at-risk populations.

No abstract available.
Chloroquine* ; Edetic Acid* ; Glycine* ; Immunoglobulin G*

Morgellons disease is a rare disease with unknown etiology. Herein, we report the first case of Morgellons disease in Korea. A 30-year-old woman presented with a 2-month history of pruritic erythematous patches and erosions on the arms, hands, and chin. She insisted that she had fiber-like materials under her skin, which she had observed through a magnifying device. We performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. Histopathological examination showed only mild lymphocytic infiltration, and failed to reveal evidence of any microorganism. The polymerase chain reaction for Borrelia burgdorferi was negative in her serum.
Adult ; Arm ; Asian Continental Ancestry Group ; Biopsy ; Borrelia burgdorferi ; Chin ; Female ; Hand ; Humans ; Korea ; Morgellons Disease* ; Nerve Fibers, Myelinated ; Polymerase Chain Reaction ; Rare Diseases ; Skin

As the mitral valve disease becomes long-standing, the patient may develop pulmonary hypertension. It was reported that after surgical correction, the elevated pulmonary vascular resistance(PVR) would fall quickly in association with the fall in left atrial pressure(LAP). This study was performed to evaluate the changes in mean pulmonary artery pressure(PAP) and PVR immediately after mitral valve replacement(MVR). Fifty six patients undergoing mitral valve replacement(MVR) were divided into two groups on the basis of the presence or absence of significant pulmonary hypertension, defined as a resting mean pulmonary arterial pressure greater than 30mmHg. After induction of anesthesia, PAP, PVR, cardiac output(CO) were measured and compared with values in postbypass period. PAP and PVR were significantly decreased(PAP from 39.64+/-1.88 to 29.18+/-1.65 mmHg, P 0.001, PVR from 6.16+/-1.14 to 3.53+/-0.62 units, P<0.05) in Group II(PAP> or = 30mmHg, n=23), whereas not changed in Group I(PAP30 mmHg, n=33)(P<0.05). Persistance of an elevated PVR may cause right ventricular failure and low-output syndrome, so that an attempt to reduce the PVR is needed postoperatiavely. This study demonstrated that the PAP and PVR fall significantly after MVR especially in patients with severe pulmonary hypertension.
Anesthesia ; Arterial Pressure* ; Humans ; Hypertension, Pulmonary ; Mitral Valve* ; Pulmonary Artery ; Vascular Resistance*

Objective: Oral frailty is associated with a decline in overall function in the elderly and increases the risk of dysphagia and aspiration pneumonia. Early diagnosis is essential to prevent these issues. This study aimed to determine the correlation between the Korean oral frailty diagnostic criteria and oral diadochokinesis (ODK) in community-dwelling elderly individuals. Methods: Six diagnostic criteria for oral frailty were examined and ODK was assessed in 100 elderly individuals aged 60 years and above residing in the Gangwon State. The correlation was analyzed using Pearson’s correlation, Spearman’s rank correlation, and multiple regression analysis. Results: The study found that elderly individuals in the later stages of life had significantly lower tongue pressure, occlusal force, chewing ability, and ODK compared to those in earlier stages. Additionally, increased age and decreased chewing ability and tongue pressure were significantly associated with a decline in ability to rapidly repeat monosyllables /pʌ/tʌ/kʌ/. Conclusion As age increases in the elderly population, the frequency of /pʌ/tʌ/kʌ/ in ODK assessments may serve as a simple screening tool for oral frailty in community-dwelling elderly individuals.

Objective: Oral frailty is associated with a decline in overall function in the elderly and increases the risk of dysphagia and aspiration pneumonia. Early diagnosis is essential to prevent these issues. This study aimed to determine the correlation between the Korean oral frailty diagnostic criteria and oral diadochokinesis (ODK) in community-dwelling elderly individuals. Methods: Six diagnostic criteria for oral frailty were examined and ODK was assessed in 100 elderly individuals aged 60 years and above residing in the Gangwon State. The correlation was analyzed using Pearson’s correlation, Spearman’s rank correlation, and multiple regression analysis. Results: The study found that elderly individuals in the later stages of life had significantly lower tongue pressure, occlusal force, chewing ability, and ODK compared to those in earlier stages. Additionally, increased age and decreased chewing ability and tongue pressure were significantly associated with a decline in ability to rapidly repeat monosyllables /pʌ/tʌ/kʌ/. Conclusion As age increases in the elderly population, the frequency of /pʌ/tʌ/kʌ/ in ODK assessments may serve as a simple screening tool for oral frailty in community-dwelling elderly individuals.

Objective: Oral frailty is associated with a decline in overall function in the elderly and increases the risk of dysphagia and aspiration pneumonia. Early diagnosis is essential to prevent these issues. This study aimed to determine the correlation between the Korean oral frailty diagnostic criteria and oral diadochokinesis (ODK) in community-dwelling elderly individuals. Methods: Six diagnostic criteria for oral frailty were examined and ODK was assessed in 100 elderly individuals aged 60 years and above residing in the Gangwon State. The correlation was analyzed using Pearson’s correlation, Spearman’s rank correlation, and multiple regression analysis. Results: The study found that elderly individuals in the later stages of life had significantly lower tongue pressure, occlusal force, chewing ability, and ODK compared to those in earlier stages. Additionally, increased age and decreased chewing ability and tongue pressure were significantly associated with a decline in ability to rapidly repeat monosyllables /pʌ/tʌ/kʌ/. Conclusion As age increases in the elderly population, the frequency of /pʌ/tʌ/kʌ/ in ODK assessments may serve as a simple screening tool for oral frailty in community-dwelling elderly individuals.

PURPOSE: Despite the increasing use of continuous renal replacement therapy (CRRT) in the neonatal intensive care unit (NICU), few studies have investigated its use in preterm infants. This study evaluated the prognosis of preterm infants after CRRT and identified risk factors of mortality after CRRT. MATERIALS AND METHODS: A retrospective review was performed in 33 preterm infants who underwent CRRT at the NICU of Samsung Medical Center between 2008 and 2017. Data of the demographic characteristics, predisposing morbidity, cardiopulmonary function, and CRRT were collected and compared between surviving and non-surviving preterm infants treated with CRRT. Univariable and multivariable analyses were performed to identify factors affecting mortality. RESULTS: Compared with the survivors, the non-survivors showed younger gestational age (29.3 vs. 33.6 weeks), lower birth weight (1359 vs. 2174 g), and lower Apgar scores at 1 minute (4.4 vs. 6.6) and 5 minutes (6.5 vs. 8.6). At the initiation of CRRT, the non-survivors showed a higher incidence of inotropic use (93% vs. 40%, p=0.017) and fluid overload (16.8% vs. 4.0%, p=0.031). Multivariable analysis revealed that fluid overload >10% at CRRT initiation was the primary determinant of mortality after CRRT in premature infants, with an adjusted odds ratio of 14.6 and a 95% confidence interval of 1.10–211.29. CONCLUSION: Our data suggest that the degree of immaturity, cardiopulmonary instability, and fluid overload affect the prognosis of preterm infants after CRRT. Preventing fluid overload and earlier initiation of CRRT may improve treatment outcomes.
Birth Weight ; Gestational Age ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Intensive Care, Neonatal ; Mortality ; Odds Ratio ; Prognosis ; Renal Replacement Therapy ; Retrospective Studies ; Risk Factors ; Survivors