GH concentration in plasma decline with age. GH and GH response to GHRH are influenced by sex hormones, thereby changing around the menopause. In several aspects, features of aging resemble those of a state of GH deficiency. It has been argued the declining GH function, along with other factors, might be a causal factor in osteoporosis. The purpose of this study was to investigate that postmenopausal osteoporosis in ovariectomized rat could be prevented by rhGH. Fifty-four Sprague-Dawley rats(weight 140-200g) were devided 3 groups. Group 1(n=18) was sham operation; Group 2(n=18) was ovariectomized and received subcutaneous injection with 0.05 cc normal saline; Group 3(n=18) was ovariectomized and received subcutaneous injection with 0.2 IU rhGH. Group 2 and 3 were injected daily, 6 day per week. Each group was devided three subgroups(n=6) and were sacrificed at 6 week, 10 week, 14 week, respectively. Group 2 showed a significant increase in body weight, femur length, serum IGF-1 level, serum PICP and ICTP level at 6 weeks, 10 weeks, 14 weeks and a significant decrease in ash weight of tibia, width of bony spicules, at 14 weeks than Group 1. Group 3 demonstrated a significant increase in body weight, femur length, serum IGF-1, serum PICP and ITCP levels and a insignificant decrease in ash weight of tibia and width of bony spicules, at 6 weeks, 10 weeks, 14 weeks than Group 1. At 14 weeks, Group 3 showed a significant increase in serum IGF-1, Serum PTH, Serum PICP. From these data, we conclude that although rhGH administration leads to an activation of bone turnover and more stimulation of bone formation, it does not prevent a bone loss in ovariectomized rat.
Aging ; Animals ; Body Weight ; Female ; Femur ; Gonadal Steroid Hormones ; Humans* ; Injections, Subcutaneous ; Insulin-Like Growth Factor I ; Menopause ; Osteogenesis ; Osteoporosis* ; Osteoporosis, Postmenopausal ; Ovariectomy ; Plasma ; Rats* ; Rats, Sprague-Dawley ; Tibia

Unfortunately, we have poor knowledge of medical technology in North Korea. This study has thus attempted to identify the level and status of medical technology development through analyzing the contents of medical textbooks currently in use. This study has assumed that three factors are influencing the level and status of medical technology in a society ; the level of socio-economic development in general, the level of scientific technology revolution and health policy. Forty textbooks are collected for this purpose. The main findings are summarized as follows: 1) North Korea has strengths in that (1) its herb drugs, which are in a broad use, are cheaper, more safe and more attainable than bio-equivalent chemical ones, and (2) the development of its medical technology was carried out with emphasis on the practical and basic health needs. 2) North Korea has weaknesses in that (1) its medical diagnostic method largely depends on manual procedures, (2) the R & D investment in the development of chemical drugs, especially antibiotics, is very small, (3) the amount of medical equipments is in a absolute shortage, and (4) the medical technology is destitute of specialty, caused mainly by the overemphasis on Juche-Uihak or herb medicine. 3) Medical technology has two faces, positive and negative so that it cannot be successfully evaluated by one. It eventually acts a positive function for public health through developments of drug, equipment and new medical treatment method. But it is also true that it has negative effects such as the dehumanization of high cost medical technology, cost hike due to over-investments in expensive equipments, and the absence of wholistic care from overspecialization. 4) We have to consider economic status and the social needs of medical care in order to evaluate the medical technology of a society. It is also the ease with North Korea. A whole picture of the North Korean medical technology could be understood only if further comprehensive studies of medical technology are to be carried out for North Korea.
Anti-Bacterial Agents ; Dehumanization ; Democratic People's Republic of Korea* ; Health Policy ; Herbal Medicine ; Investments ; Public Health

No abstract available.
Autonomic Pathways* ; Rectal Neoplasms* ; Urodynamics*

The relaxed G-tolerances of 16 female cadets of ROKAF academy and 19 male privates were compared. The relaxed G-tolerance level was measured as visual endpoint (gray out or loss of peripheral light loss) during G-force raise steadily at 0.1 G/s. The G-stimulations were repeated twice with the interval of 30 s for 4 days (female cadets, 9 a.m.; male privates, 10 a.m.). The correlation between the relaxed G-tolerance level and their physical factor (height, sitting height, weight and lean body mass) and muscle strength (power of abdomen, back and thigh) was investigated. The average value of the relaxed G-tolerance levels of female cadets for 4 days was significantly higher than the one of male privates (4.23 +/-0.60, n=111; 4.04 +/-0.64, n=92; student 's t-test, P<0.05). However, the training effect of 4 days was not seen in either female cadet or male private group. The weight and lean body mass have significant positive correlation with the relaxed G-tolerance level. Also, the peak torque of thigh muscle have a strong positive correlation with it, but the endurance ratio does not.
Abdomen ; Female ; Humans ; Male ; Muscle Strength ; Thigh ; Torque

No abstract available.
Adult* ; Humans ; Magnetic Resonance Imaging*

No abstract available.
Fractures, Open*

No abstract available.
Spondylolisthesis*

Histiocytosis-X has several mode of presentation, from the mildest solitary eosinophilic granuloma of bone to the most severe, with multiple granulomata in bones and soft tissues. This disease previously described as eosinophilic granuloma, Hand-Schuller-Christian disease and Letterer-Siwe disease. Lichtenstein (1953) used the term histiocytosis-x to encompass the above three names. We experienced a case of histiocytosis-x which had occured at multiple site of bones. The patient has good general condition with complete subsidance of specific symtoms and signs in our thirty-eight months follow up treatment.
Eosinophilic Granuloma ; Follow-Up Studies ; Histiocytosis, Langerhans-Cell ; Humans

Older children with neglected ongenital dislocation of the hip is not easily reduced. Even if reduction is achieved, the overstretched muscle tends to resume its original length, provoking either a redilocation or a pressure necrosis with resultant stiffness of the hip joint and deformity. The authors treated 15 cases of the C.D.H. in older children by combined procedure of open reduction, Salter's innominate osteotomy, and femoral shortening with redirection of the femoral head. The results were obtained in 15 operated hips with follow-up from 1 to 5 and 3/12 years. l. We had good results in 11 among 15 cases(73%). 2. Femoral shortening was spontaneously correctd 1.3cm in 1 year, 2.1cm in 2 years follow-up. 3. The improvement of acetabular index following Salter's innominate osteotomy was about 12.4 degrees. 4. We had no serious complication such as avascular necrosis, stiffness, and redislocation, but 3 cases of mild limitation of hip joint motion were noted. 5. Two skin incision were more convenient in operative procedure and handling of instruments than one incision(Klisić).
Acetabulum ; Child ; Congenital Abnormalities ; Dislocations ; Femur ; Follow-Up Studies ; Head ; Hip ; Hip Joint ; Humans ; Necrosis ; Osteotomy ; Skin ; Surgical Procedures, Operative

The most common fracture about the elbow joint in chilren is a supracondylar fracture. The displaced fracture is difficult to manage due to the potential danger of Volkmann's ischemia, nerve injury, and malunion, During the period of 6 years from June, 1979 to June, 1985, 63 children with supracondylar fractures of the humerus were treated at Pusan Paik Hospital, Inje Medical College, and analyzed. The results are summarized as follows: 1. The average age was 7.1 years, ranged from 1 year to 14 years, and the male and female ratio was 2.5: l. 2. In type of fracture, extension type was 92% and flexion type was 8%. In displacement of fracture, Grade I was only 2 cases, Grade III and IV were 87.3%. Posteromedial displacement was 42.8% (27 cases). 3. At the time of admission, 15cases(23.8%) accompanied nerve injury, of these median nerve injury (9 cases) was most common. All the patient with nerve injury were completely recovered within 14 months after reduction. 4. Severe cubitus varus was 14.2%, and severe limitation of elbow motion was 1.6%. 5. Of 61 displaced fractures, 37 patients were treated with closed reduction and percutaneous pin fixation. By Flynn's criteria, satisfactory results were obtained in 36 of the 37 patients(97.3%) treated with percutaneous pinning. 6. In the displaced fractures, closed reduction and percutaneous pinning is a satisfactory method for obtaining and maintaining reduction while preserving vascular function, if acute flexion is necessary for stable reduction.
Busan ; Child ; Clinical Study ; Elbow ; Elbow Joint ; Female ; Fractures, Closed ; Humans ; Humerus ; Ischemia ; Male ; Median Nerve ; Methods