It has been reported that the cause of the bacterial endophthalmitis following cataract extraction and intraocular lens implantation was G(+) organisms in most cases. However, the endophthalmitis caused by G(-) organisms has worse prognosis than that by G(+)organisms. We experienced a case of Stenotrophomonas maltophilia endophthalmitis which has not yet been reported in Korea. A 77-year-old female presented with blurred vision, conjunctival injection and ocular pain 5 days after cataract extraction and intraocular lens implantation. Ocular findings such as corneal edema, hypopyon and thick posterior capsular opacity were consistent with infectious endophthalmitis. Culture of vitreous aspirate isolated Stenotrophomonas maltophilia 15 days after cataract extraction.
Aged ; Cataract Extraction ; Cataract* ; Corneal Edema ; Endophthalmitis* ; Female ; Humans ; Korea ; Lens Implantation, Intraocular ; Prognosis ; Stenotrophomonas maltophilia* ; Stenotrophomonas*

Verrucous hyperplasia of the distal stump skin is a rare condition which shows multiple, irregular warty papules and plaques but histologically no evidence of viral warts. It has been suggested that verrucous hyperplasia results from persistent stump edema, usually when the distal stump is unsupported in the prosthesis socket. We present a 53-year-old male who showed verrucous plaques on the distal stump skin and also showed edematous change with oozing. He has been wearing a below-the-knee prosthesis for 35 years since a traumatic amputation and has not changed the prosthesis for 30 years. Histopathological findings showed hyperkeratosis, parakeratosis, acanthosis, papillomatosis, dermal edema, fibrosis, dermal vessel proliferation and dilatation. He was diagnosed as having verrucous hyperplasia with lymphedema by clinical and histopathological findings.
Amputation ; Amputation, Traumatic ; Amputees* ; Dilatation ; Edema ; Fibrosis ; Humans ; Hyperplasia* ; Lymphedema* ; Male ; Middle Aged ; Papilloma ; Parakeratosis ; Prostheses and Implants ; Skin ; Warts

Several conditions such as nipple eczema, erosive adenomatosis of the nipple, mammary Paget's disease and hyperkeratosis of the nipple and areola occur exclusively in the region of the areola and nipple. Seborrheic keratosis is a benign epidermal lesion that can appear on any part of the body but reported cases appearing on the areola are very rare. Cutaneous horn generally presents as an asymptomatic, conical keratotic mass, which commonly occurs on sun-exposed skin, and has an underlying condition that may be benign, premalignant, or malignant. Seborrheic keratosis is a well known benign underlying condition of the cutaneous horn. We herein present a 49-year-old male with a conical hyperkeratotic mass on his right areola, which, upon microscopic examination was revealed to be seborrheic keratosis.
Animals ; Eczema ; Horns* ; Humans ; Keratosis, Seborrheic* ; Male ; Middle Aged ; Nipples ; Paget's Disease, Mammary ; Skin

Metric dimensions of skull of Korean adults were measured and the indices of each dimension were calculated to identify the morphological characteristics of neurocrania of Koreans in 97 cases. The results were as follows. The maximal anteroposterior length was 171.6±8.4 (149.0~191.0)mm and the maximal lateral length (maximal breadth) was 142.4±5.4 (128.0~155.0)mm. The horizontal cranial index was 83.3±5.0 and therefore the neurocrania of Koreans were classified to brachycranic type (rounded cranium). The auriculo-bregmatic height was 119.3±5.1mm and basio-bregmatic height was 140.5±4.9mm. The height-breadth index on the basis of the auriculo-bregmatic height was 98.5±3.6, and belong to medium skull. The height-length index was 81.8±3.8, therefore they belonged to high skull. Height-breadth index on the basis of auliculo-bregmatic height was 85.4±5.7, and belonged to medium skull, and the height-length index was 70.5±5.4 and belonged to high skull. In the case of mean height index, the auriculo-bregmatic height was 77.2±5.0 (high skull), basio-bregmatic height was 87.6±2.6 (high skull).
Adult* ; Humans ; Skull

BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Secondary amyloidosis can occur as a complication of chronic systemic inflammatory and infectious diseases. Until now there has been no report of secondary amyloidosis associated with MS. We report herein a case of renal biopsy-proven secondary amyloidosis in a patient with MS. CASE REPORT: A 41-year-old woman with MS was hospitalized due to aggravated quadriparesis and edema in both lower extremities. Laboratory findings showed nephrotic-range proteinuria and hypoalbuminemia. A percutaneous renal biopsy procedure was performed, the results of which revealed secondary amyloid-A-type amyloidosis associated with MS. CONCLUSIONS: This is the first report of secondary amyloidosis associated with MS.
Adult ; Amyloidosis ; Biopsy ; Central Nervous System ; Communicable Diseases ; Demyelinating Diseases ; Edema ; Female ; Humans ; Hypoalbuminemia ; Lower Extremity ; Multiple Sclerosis ; Nephrotic Syndrome ; Proteinuria ; Quadriplegia

Linear lichen planus (LLP) is a rare variant of lichen planus, which accounts for 0.24-0.62% of all patients with lichen planus. Blaschko lines are the pattern assumed by many different nevoid and acquired skin diseases on the human skin, which present with a characteristic S-shape on the abdomen, a V-shape near the posterior midline, a linear pattern on the lower trunk and limbs, and whorls on the scalp and abdomen. Multiple LLP along the lines of Blaschko has been rarely reported. Differential diagnosis of LLP includes lichen striatus, epidermal nevi, linear psoriasis, inflammatory linear verrucous epidermal nevus (ILVEN), linear Darier disease, linear lupus erythematosus, and linear lichen nitidus. We herein describe a 49-year-old female who showed multiple linear erythematous, brownish papules on her right trunk, shoulder, arm, and groin with typical histopathologic findings of lichen planus.
Abdomen ; Arm ; Darier Disease ; Diagnosis, Differential ; Extremities ; Female ; Groin ; Humans ; Lichen Nitidus ; Lichen Planus* ; Lichens* ; Middle Aged ; Nevus ; Nevus, Sebaceous of Jadassohn ; Psoriasis ; Scalp ; Shoulder ; Skin ; Skin Diseases

A pancreatic hamartoma is a rare benign lesion that may be mistaken for malignancy. A pancreatic hamartoma can present with vague, non-specific symptoms, which can be difficult to diagnose despite modern diagnostic tools. We report here a pancreatic hamartoma diagnosed after surgical resection. A 52-year-old female presented with postprandial abdominal discomfort. Abdominal computed tomography and pancreatic magnetic resonance imaging revealed a 2.2 x 2.5-cm cystic mass in the pancreatic head. The patient underwent a pylorus-preserving pancreaticoduodenectomy. The histopathological and immunohistochemical studies helped make the diagnosis of pancreatic hamartoma. Here, we report a case of pancreatic hamartoma and review the relevant medical literature.
Female ; Hamartoma ; Head ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Pancreas ; Pancreaticoduodenectomy

Prurigo pigmentosa is a rare inflammatory dermatosis of unknown etiology characterized by recurrent, pruritic, erythematous papules with gross reticulate hyperpigmentation. The cause of prurigo pigmentosa is unknown. Exogenous factors, fasting, dieting, ketosis, diabetes mellitus and pregnancy have been reported to be associated with prurigo pigmentosa. We now present two cases of prurigo pigmentosa associated with dieting. These findings suggest that the ketosis produced by dieting may well contribute to the pathogenesis of prurigo pigmentosa.
Diabetes Mellitus ; Diet ; Fasting ; Hyperpigmentation ; Ketosis ; Pregnancy ; Prurigo* ; Skin Diseases

Aberrant expression of BORIS/CTCFL (Brother of the Regulator of Imprinted Sites/CTCF-like protein) is reported in different malignancies. In this study, we characterized the entire promoter region of BORIS/CTCFL, including the CpG islands, to assess the relationship between BORIS expression and lung cancer. To simplify the construction of luciferase reporter cassettes with various-sized portions of the upstream region, genomic copies of BORIS were isolated using TAR cloning technology. We analyzed three promoter blocks: the GATA/CCAAT box, the CpG islands and the minisatellite region BORIS-MS2. Polymorphic minisatellite sequences were isolated from genomic DNA prepared from the blood of controls and cases. Of the three promoter blocks, the GATA/CCAAT box was determined to be a critical element of the core promoter, while the CpG islands and the BORIS-MS2 minisatellite region were found to act as regulators. Interestingly, the polymorphic minisatellite region BORIS-MS2 was identified as a negative regulator that repressed the expression levels of luciferase reporter cassettes less effectively in cancer cells compared with normal cells. We also examined the association between the size of BORIS-MS2 and lung cancer in a case–control study with 590 controls and 206 lung cancer cases. Rare alleles of BORIS-MS2 were associated with a statistically significantly increased risk of lung cancer (odds ratio, 2.04; 95% confidence interval, 1.02–4.08; and P=0.039). To conclude, our data provide information on the organization of the BORIS promoter region and gene regulation in normal and cancer cells. In addition, we propose that specific alleles of the BORIS-MS2 region could be used to identify the risk for lung cancer.
Alleles ; Clone Cells ; Cloning, Organism ; CpG Islands ; DNA ; Gene Expression* ; Luciferases ; Lung Neoplasms* ; Lung* ; Minisatellite Repeats* ; Promoter Regions, Genetic

BACKGROUND: It was demonstrated that ultraviolet(UV) B light induces the release of IL-1α in cultured human epithelial cell line and augmentation of GM-CSF production by UVB is reported to be mediated by IL-1α in the murine keratinocyte cell line Pam 212. OBJECTIVE: The purpose of this study was to evaluate the effects of UVB on kinetic profile of IL-1 and GM-CSF mRNA expression and to see whether synthesis of GM-CSF by UVB can be completely inhibited by blocking IL-1α mediated pathway. METHODS: We used a competitive RT-PCR for measuring cytokine gene expression in epithelial cell line after UV radiation. RESULTS: The IL-1α mRNA increased as early as 1h after UV irradiation, and then decreased at 3h after the irradiation. Thereafter, the response of IL-1α mRNA was upregulated with a second peak at 6h after the UV irradiation. However, mRNA for GM-CSF increased at 1h after UV light exposure and anti-IL-1α antibodies could only partially inhibit UV-augmented GM- CSF production. CONCLUSION: UVB induced GM-CSF production seemed to be mainly mediated by UVB induced IL-1α but these results suggest that UVB may also induce GM-CSF production through an IL-1α independent pathway.
Antibodies ; Cell Line ; Epithelial Cells* ; Gene Expression ; Granulocyte-Macrophage Colony-Stimulating Factor* ; Humans ; Interleukin-1 ; Keratinocytes ; RNA, Messenger ; Ultraviolet Rays ; Up-Regulation*