1.Change of Serum Cardiac Troponin T and Fetal Troponin T Isoform in Rats with Adriamycin-induced Cardiac Injury.
Young Mi HONG ; Byung Kwan LIM ; Jae Ok SHIN ; Eun Seok JEON
Korean Circulation Journal 2002;32(6):485-491
BACKGROUND AND OBJECTIVES: Cardiac troponin T (cTnT) has been used as a very sensitive marker of cardiac injury caused by ischaemia, myocarditis, and cardiomyopathy. After cardiac injury, the fetal cTnT isoform expression in the heart and serum cTnT increases. To investigate the increased levels of serum cTnT, and the expression of fetal cTnT isoform in the heart, that can predict myocardial injury, we measured serum cTnT levels and the fetal cTnT isoform expression at various time points during the early phase of myocardial toxicity induced by adriamycin (ADR) in rat. MATERIALS AND METHODS: Male Sprague-Dawley rats were injected, intraperitoneally, with ADR (5 mg/kg) twice a week for 2 weeks. Control rats were injected with saline. Serum cTnT levels were measured by ELISA. The ratio of fetal/adult (F/A) cTnT isoform expression (%) was semi-quantified by RT-PCR using total RNA from frozen hearts. RESULTS: Serum cTnT levels did not increase by 1 week after ADR injection, but increased significantly after 2 weeks. The ratio of F/A cTnT in the heart significantly increased from day 1, peaked at 1 week and persisted until the end of 2 week. CONCLUSION: The expression of the fetal cTnT isoform occurred from 1 day after ADR injection when the serum cTnT levels were still normal. Although the serum cTnT level is a very sensitive, and an early marker, of cardiac damages, the fetal cTnT isoform expression in the endomyocardial biopsy specimen may be a more sensitive and an earlier marker in the ADR-induced myocardial damage.
Animals
;
Biopsy
;
Cardiomyopathies
;
Cardiomyopathy, Dilated
;
Doxorubicin
;
Enzyme-Linked Immunosorbent Assay
;
Heart
;
Humans
;
Male
;
Myocarditis
;
Rats*
;
Rats, Sprague-Dawley
;
RNA
;
Troponin T*
;
Troponin*
2.Two Cases of SAPHO Syndrome.
Hyung Ran YUN ; Sung Soo JUNG ; Hee Kwan KOH ; Tae Seok YOO ; Je Kyung LEE ; Kwan Pyo HONG ; Tae Hwan KIM ; Jae Bum JUN ; In Hong LEE ; Sang Cheol BAE ; Dae Hyun YOO ; Seong Yoon KIM
The Journal of the Korean Rheumatism Association 1997;4(2):162-167
SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome designates a group of articular and osseous manifestations frequently combined with skin disorders. Its fundamental component is inflammatory, pseudoinfectious, and sterile osteitis. The anterior chest wall is the most frequent localization and all the components of this structure may be involved. Palmoplantar pustulosis, psoriasis, acne conglobata, acne ulcerans, acne fulminans, pyoderma gangrenosum can be associated with the characteristic bone lesions. We report two cases of SAPHO syndrome : A 40-year-old female presented with both buttock pain with hyperostosis, costochondritis, synovitis and pustulosis palmaris and a 23-year-old male presented with migrating polyarthritis with costochondritis, synovitis, acne, pustulosis.
Acne Vulgaris
;
Acquired Hyperostosis Syndrome*
;
Adult
;
Arthritis
;
Buttocks
;
Female
;
Humans
;
Hyperostosis
;
Male
;
Osteitis
;
Psoriasis
;
Pyoderma Gangrenosum
;
Skin
;
Synovitis
;
Thoracic Wall
;
Young Adult
3.Long-erm Follow-p of Patients Treated with Interferon Alfa for Chronic Hepatitis B.
Jong Eun YEON ; Yeon Seok SEO ; Yoon Hong KIM ; Sang Hoon PARK ; Oh Sang KWON ; Kwan Soo BYUN ; Chang Hong LEE
The Korean Journal of Hepatology 1999;5(1):12-21
BACKGROUND/AIMS: Several randomized controlled studies have shown that responders who had treated with interferon alpha for chronic hepatitis B had better rate of sustained loss of HBeAg and HBV DNA than non-esponders. These studies also showed that non-esponders had higher rates of liver related complication and mortality. But there is very little data on how well sustained responders are and whether the responders eventually lose HBsAg in Korea. The aims of this study were to better define the long term remission of chronic hepatitis B induced by interferon alfa therapy and compare the clinical outcome among the interferon responders and non-esponders in Korea. METHODS: Sixty-ight patients with chronic hepatitis B who were treated with interferon alfa between 1987 and 1998 were followed up for serologic status (HBsAg, HBeAg, HBV DNA), biochemical tests and liver related complication or mortality. RESULTS: Among 68 patients with chronic hepatitis B who were treated with interferon alfa, 28 (41%) responded to treatment with loss of HBeAg within 1 year of starting treatment. Up to 129 months (mean 58 months) after therapy, responders had higher rate of cumulative clearance of HBeAg at five years than non-esponders (100% vs 35.1%, p<0.05). Responders had maintained the normal serum ALT than nonresponders at five years (94% vs 55.6%, p<0.05). Loss of HBsAg was not different between responders and non-esponders (5% vs 4%, NS). The rates of liver related complication and mortality did not differ between both groups. Delayed clearance of HBeAg occured in twelve out of forty non-esponders (30%). There were no differences in age, baseline ALT, histologic finding of liver biopsy, HBV DNA at the end of first year after study with IFN therapy between the non-esponders with and without delayed clearance of HBeAg. CONCLUSION: Remission in chronic hepatitis B induced by alfa interferon maintained in long duration. But clinical outcomes such as liver related complication, mortality and the elimination of HBV infection have no differences between responders and non-esponders. Further studies are needed for the role of interferon therapy in long-erm clinical outcome for chronic hepatitis B.
Biopsy
;
DNA
;
Hepatitis B e Antigens
;
Hepatitis B Surface Antigens
;
Hepatitis B, Chronic*
;
Hepatitis, Chronic*
;
Humans
;
Interferon-alpha*
;
Interferons*
;
Korea
;
Liver
;
Mortality
4.Analytic Study of the Clinical Features of Korean Juvenile Rheumatoid Arthritis (JRA).
Kwan Taek OH ; Sung Soo JUNG ; Tae Seok YOO ; Je Kyung LEE ; Yong Ho SONG ; Ja Hun JUN ; Hee Kwan KOH ; Tae Hwan KIM ; Jae Bum JUN ; In Hong LEE ; Sang Cheol BAE
The Journal of the Korean Rheumatism Association 1997;4(2):121-130
OBJECTIVE: To investigate the clinical characteristics of Korean JRA and the possible profiles related to prognosis and to compare these data to pre-existing occidental reports. METHODS: 140 cases of JRA patients were randomly selected from 1986 through 1995. Juvenile ankylosing spondylitis was excluded with the aid of modified New York criteria for ankylosing spondylitis. We used the classification of progression of rheumatoid arthritis (radiological stage III+IV / I+II+III+IV) as a index of prognosis. The study factors were sex, age, type, affected joints, degree of destruction of joint, anti-nuclear antibody (ANA), rheumatoid factor (RF), HLA-B27 and extra-articular manifestations. Chi-square test, One-way ANOVA test, and Pearson' s correlation coefficient were used as statistical methods. RESULTS: Our study show results as follows : (1) Systemic onset type (ll%) { polyarthritis subset (66%), oligoarthritis subset (34%) }, oligoarthritis onset type (62%) { sero (-) -HLA-B27 (+) subset (66%) , RF (+) subset (20%), not otherwise classified subset (14%) ANA(+)-chronic uveitis subset(O%) }, polyarthritis onset type (27%) { RF(+) subset (66%), not otherwise classified subset (34%) }, (2) Sex ratio was M:F=1.8:l. (3) Age of onset was 11+3.6 years. (4) Affected joints were knee, ankle, hand in decreasing order of frequency. (5) Patients show seropositivity of RF in 31%, HLA-B27 in 54%, ANA in 8%. (6) Chronic uveitis was observed in 7 cases (5%) (all oligoarthritis onset type, M:F=6:1, age of onset 11+4.3 years, ANA (0%), HLA-B27 (86%) , 2 cases leading to blindness. (7) Destructive bone change was significantly more prominent in female (p<0.01) , RF(+) (p<0.01), HLA-B27(-) (p<0.01) , polyarthritis onset type (p=0.02). CONCLUSIONS: In this study, we obtained interesting results that are somewhat different from Occidental data in sex ratio (male dominance), age of onset (older age) , profiles of HLA-B27 (high positivity in spite of low HLA-B27 positivity in Korean (about 2. 3%) , low rate of destructive change) , ANA (low positivity, older age of onset) , chronic uveitis (low incidence, male dominance, older age of onset, high association with HLA-B27, not associated with ANA) . This study suggests possible racial difference in clinical features of JRA. But for prove of racial difference, further multi-center trial and large scale epidemiological study should be done.
Age of Onset
;
Ankle
;
Antibodies, Antinuclear
;
Arthritis
;
Arthritis, Juvenile*
;
Arthritis, Rheumatoid
;
Blindness
;
Classification
;
Epidemiologic Studies
;
Female
;
Hand
;
HLA-B27 Antigen
;
Humans
;
Incidence
;
Joints
;
Knee
;
Male
;
Prognosis
;
Rheumatoid Factor
;
Sex Ratio
;
Spondylitis, Ankylosing
;
Uveitis
5.A Case of Intracranial Dermoid Cyst Associated with Scalp Abscess.
Sung Keun OH ; Sung Dae CHO ; Young Jin HONG ; Byong Kwan SON ; Young Se KWON ; Eun Young KIM ; Myung Kwan LIM ; Seok Jin CHOI
Journal of the Korean Child Neurology Society 2010;18(2):317-321
Intracranial dermoid cyst is a rare congenital disease originating in the embryo. Intracranial dermoid cysts are usually detected before five years of age; however, asymptomatic cysts have been discovered after the third decade of life through various complications. Sometimes, there are neurologic symptoms caused by a cystic mass effect and if there is a dermoid sinus, purulent infections can occur. Early diagnosis is important and as such, CT or MR imaging for recognition of the location, size, and characteristics of the cysts are recommended before surgical resection. Extradural dermoid cysts with an intact occipital dermoid sinus are a rare event. We report a case of intracranial dermoid cyst associated with scalp abscess. In this case, a three-year-old boy was presented with scalp abscess and we performed MR imaging, which revealed a cystic region. The prognosis after resection operation was good without any complication.
Abscess
;
Dermoid Cyst
;
Early Diagnosis
;
Embryonic Structures
;
Neurologic Manifestations
;
Prognosis
;
Scalp
;
Spina Bifida Occulta
6.Evaluation of the Phoenix Automated Microbiology System for Detecting Extended-Spectrum beta-Lactamase in Escherichia coli, Klebsiella species and Proteus mirabilis.
Kyo Kwan LEE ; Sung Tae KIM ; Ki Suk HONG ; Hee Jin HUH ; Seok Lae CHAE
The Korean Journal of Laboratory Medicine 2008;28(3):185-190
BACKGROUND: The aim of this study was to compare the BD Phoenix (Beckton Dickinson Diagnostic Systems, USA) extended-spectrum beta-lactamase (ESBL) test with the Clinical and Laboratory Standards Institute (CLSI) ESBL phenotypic confirmatory test by disk diffusion (CLSI ESBL test) in Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca and Proteus mirabilis. METHODS: We tested 224 clinical isolates of E. coli, K. pneumoniae, K. oxytoca and P. mirabilis during May 2006 to March 2007. These isolates were examined by the Phoenix and the CLSI ESBL tests simultaneously. For the isolates showing discordant results between the two tests, boronic acid disk test was performed to differentiate AmpC beta-lactamase and ESBL. RESULTS: Among the 224 clinical isolates, 75 and 79 isolates were positive for ESBL by CLSI ESBL test and Phoenix test, respectively. Having detected 4 more isolates as ESBL-producers, Phoenix test showed a 98.2% agreement with a 100% sensitivity and 97.3% specificity compared with CLSI ESBL test. Among the four false positive isolates, three were AmpC-positive but ESBL-negative. CONCLUSIONS: The BD Phoenix ESBL test was sensitive and specific, and can be used as a rapid and reliable method to detect ESBL production in E. coli, Klebsiella species, and P. mirabilis.
Automation
;
Bacterial Proteins/classification/*metabolism
;
Disk Diffusion Antimicrobial Tests
;
Escherichia coli/drug effects/*enzymology/isolation & purification
;
Humans
;
Klebsiella/*enzymology
;
Klebsiella oxytoca/drug effects/enzymology/isolation & purification
;
Klebsiella pneumoniae/drug effects/enzymology/isolation & purification
;
*Microbial Sensitivity Tests
;
Proteus mirabilis/drug effects/*enzymology/isolation & purification
;
Reagent Kits, Diagnostic
;
Sensitivity and Specificity
;
beta-Lactamases/classification/*metabolism
7.Characteristics of Children Whose First Seizure Attack Presented as Status Epilepticus.
Seok Woo PARK ; Ji Yeon CHANG ; Young Se KWON ; Young Jin HONG ; Byong Kwan SON
Journal of the Korean Child Neurology Society 2003;11(2):262-268
PURPOSE: Status epilepticus(SE) is a pediatric and neurologic emergency associated with significant morbidity and mortality. Prompt recognition and management are needed for successful outcomes. We evaluated, clinical manifestations, treatment and prognosis of the patients whose first seizure attacks were presented as SE. METHODS: According to the department of pediatrics and the emergency room in Inha University Medical Center, there were a total of 25 children between 1 month and 5 years old who were diagnosed as status epilepticus from July 1996 to June 2002. Also, their medical records were reviewed and analyzed interms of age distribution, accompaning diseases, the types and duration of convulsion, medications, EEG and MRI findings and prognosis. RESULTS: Twenty-five cases were studied. The mean age at the time of the diagnosis was 20+/-1.6 months and 80% of the patients were less than 3 years old. The most common type of the status epilepticus was generalized tonic clonic seizure comprising 15 cases(60%). 64% of the patients were symptomatic:fever(40%), CNS infection(20%), ischemic injury(4%) while 36% were idiopathic. Seizure attacks were terminated within an hour in seventeen patients(68%) and they controlled by one antiepileptic drug in thirteen patients(52%). Of the 20 EEGs, abnormal findings were shown in 13 cases(65%); namely, electrical seizure(30%), abnormal background(30%), and focal epileptiform discharge(5%). Of the 19 brain MRIs, abnormal findings were shown in 9 cases(47%). CONCLUSION: The children whose first seizure attack were presented as SE were less than 3 years old. The prognosis is good in that most of the seizure attacks were terminated within an hour and controlled by one epileptic drug. However those seizure attacks with longer duration, multiple antiepileptic druge and underlying causeare had poor prognosis.
Academic Medical Centers
;
Age Distribution
;
Brain
;
Child*
;
Child, Preschool
;
Diagnosis
;
Electroencephalography
;
Emergencies
;
Emergency Service, Hospital
;
Humans
;
Magnetic Resonance Imaging
;
Medical Records
;
Mortality
;
Pediatrics
;
Prognosis
;
Seizures*
;
Status Epilepticus*
8.A Case of Cystic Duct Stone and Cholecystitis Misdiagnosed as Gall Bladdr Carcinoma: A case report.
Byung Ihn CHOI ; Myoung Won KANG ; Sang Sook LEE ; Soon Ho KIM ; Jong Kwan KIM ; Phil Seok ON ; Hyang Soon YEO ; Hong Bae PARK
Korean Journal of Gastrointestinal Endoscopy 1989;9(2):215-219
A 56 year old female was admitted because of the right upper quadrant mass for 4 days. She complained of intermittent colicky RUQ pain, fever and chills. So diagnostic procedures was performed: Blood chemistry testings. Ultrasonography. Barium enema, Liver scan, Hepatobiliary scan, ERCP and Abdomen CT, which diagnosed as gall bladder carcinoma. So explolaparotomy was performed and gross operative finding was gall bladder carcinoma with metastatic lymph node and cystic duct stone. So cholecystectomy, hemigastrectomy and anterior segmentectomy of right liver was done. But the biopsy result was cystic duct stone, cholecystitis and gall bladder empyema.
Abdomen
;
Barium
;
Biopsy
;
Chemistry
;
Chills
;
Cholangiopancreatography, Endoscopic Retrograde
;
Cholecystectomy
;
Cholecystitis*
;
Cystic Duct*
;
Enema
;
Female
;
Fever
;
Humans
;
Liver
;
Lymph Nodes
;
Mastectomy, Segmental
;
Middle Aged
;
Ultrasonography
;
Urinary Bladder
9.A Case of Dieulafoy's Lesion Presenting Upper Gastrointestinal Bleeding in a Child in the Acute Phase of Kawasaki Disease.
Seung Min LEE ; Seok Woo PARK ; Yun Hee KIM ; Ji Eun LEE ; Young Jin HONG ; Byong Kwan SON
Korean Journal of Pediatrics 2004;47(10):1124-1127
Dieulafoy's lesion is an unusual cause of massive gastrointestinal bleeding resulting from the erosion of an abnormally large submucosal artery. Recently, improvement of endoscopic techniques has made effective hemostasis possible in most cases of Dieulafoy's lesion. Aspirin, which is an anti-inflammatory agent, increases the incidence of major upper gastrointestinal complications. Gastroduodenal mucosal injury associated with aspirin therapy in patients in the acute phase of Kawasaki disease is a rare complication that may require urgent medical intervention. We experienced a rare case of active bleeding from Dieulafoy's lesion in the stomach who was treated with oral aspirin in the acute phase of Kawasaki disease. If there is massive hematemesis during the treatment of Kawasaki disease, Dieulafoy's lesion should be considered even though it is rare.
Arteries
;
Aspirin
;
Child*
;
Hematemesis
;
Hemorrhage*
;
Hemostasis
;
Humans
;
Incidence
;
Mucocutaneous Lymph Node Syndrome*
;
Stomach
10.The effect of 6 weeks of treatment with inhaled budesonide on bronc-hial hyperresponsiveness and adrenal function in asthmatic patients.
Kwan Hyoung KIM ; Yong Seok OH ; Chi Hong KIM ; Soon Seong KWON ; Young Kyoon KIM ; Ki Don HAN ; Hwa Sik MOON ; Jeong Sup SONG ; Sung Hak PARK
Tuberculosis and Respiratory Diseases 1992;39(3):219-227
No abstract available.
Budesonide*
;
Humans