To observe developing process of human fetal skin during intrauterine life, morphological studies in light microscopic level were made based on 27 human embryos and 76 fetuses ranging from 4 to 40 gestation weeks. The fetuses were the products of induced abortion and were found to have no associated diseases of congenital anomalies at the autopsy. Ten different portions of the body were sampled and examined. They were scalp, forehead, face, chest, abdomen, back, palm, sole, finger and toe. In embryos two different portions; cephalic and caudal portions were examined: The following results were obtained: 1) A single layer of undifferentiated cell was the primitive epidermis at the 4th week and it was followed by two layered epidermis consisting of periderm and primitive basal cell layer. Epidermal ridges started to develop along with primitive eccrine and hair germs as clustering of basal cells at the llth week. Stratum inter-medium was formed at the 12th week, and primitive granular cell layers and keratin formation in association with hair follicles at the 19th week forming earliest adult type epidermis, followed by progressive maturation. 2) The thickness of the fetal epidermis and keratin layer increased as the fetal age approached to the term with its slightly different developmental pattern by the site of body. Cephalic protions developed slightly earlier than the other parts. 3) The developmental pattern of various portions of epidermis could be categorized into three groups; (1) scalp, forehead and face; (2) chest, abdomen and back; (3) palm, sole, finger and toe.
Adult ; Male ; Female ; Humans

The study presents the application of STR polymorphisms to male identification in the cases of a serial rapist in Korea. Since October 2000 a rapist from Cheongju city (a town located in central district) committed at least 36 rapes. DNA profiles obtained from semen stains, buccal cells and tongue tissue left at the scenes of crime and vaginal swabs of victims gave information that one and the same man had committed all the rapes. The Y-chromosome haplotype (12 loci) obtained was used for the identification process of rapist in mixed genotypes including victim's alleles. The crime scene data were referred from investigating police authorities described the relationship of victim to the offender, victim's age, time and place of sexual assault and rape locations. The behavioural analysis of crime scenes showed more similarities than differences for related crimes. These components were usually assessed in terms of proximity in time and space. Certain crime scene aspects of a serial rapist help identify components of offender spatial behaviour. As a result of this work, future research on the geography of rape and behavioural aspects of rapist will be directed towards those aspects of offences, which have been identified as relevant to the distance between an offender's base, and the site where he approached his victim.
Alleles ; Chungcheongbuk-do ; Coloring Agents ; Crime* ; Criminals ; DNA ; Genotype ; Geography ; Haplotypes ; Humans ; Korea ; Male* ; Police ; Rape ; Semen ; Tongue

No abstract available.
Emergencies* ; Emergency Service, Hospital*

We report a case of epidermolysis bullosa simplex occurred in a 12-year-old girl, who presented with intractable bullous lesions of the hands and feet after minor traumas ever since her early neonatal period. The bullous lesions were noted on the 2nd and 4th webs of the fingers and dorsum of the hands as well as on the skin of the ankle. The lesions were healed without scar formation. Family history was not contributary and seasonal pattern was not noted. Histologic sections revealed intraepidermal bullae just above the well preserved basement membrane. Electron microscopic findings revealed cytolysis of basal cells with preservation of the basement membrane, indicating the epidermal type of epidermolysis bullosa simplex.
Infant, Newborn ; Humans

Sebaceous adenoma is a rare solitary or multiple yellow, circumscribed neoplasm consisting of sharply demarcated, proliferating lobules or irregular size and shape that are composed of three cell bypes: basal cells, mature and transitional sebaceous cells. We reported a case of extremely rare sebaceous adenoma arising in caruncle of the left eye in a 78-year-old female. A polypoid tumor nodule, measuring 0.6x0.5 cm, was noticed 6 months before resection. It was grayish white with granular surface. There is no evidence of associated visceral neoplasm. Histopathologically, it revealed a lobulated tumor, composed of equal amount of highly differentiated sebaceous and intermediate transitional epithelium with minor participation of basaloid cells. This tumor is thought to be the neoplasm of the sebaceous gland normaly present in the caruncle of the eye rather than ectopic origin.
Female ; Humans ; Adenoma

A rare case of mucoid cyst of the penile skin in a 23 year-old man is reported, which has been presented as a movable, superficial and no tender nodule, measuring 0.8 cm in maximum diameter at the periurethral meatus of the glans for 6 months. This nodule was removed by simple excision and proved to be a mucoid cyst of penile skin, which was lined by pseudostratified columnar epithelium with occasional mucous epithelium and glands, suggesting its origin is most likely from sequestrated periurethral glands.
Male ; Humans ; Cysts

The developing process of the hair of the fetal skin was studied. The ages of 103 human embryos and fetuses ranged from 4 to 40 gestation weeks. Ten different sites were selected, i.e., scalp, forehead, cheek, chest, abdomen, back, palm, sole, finger and toe. For the embryos 3 sites were studied, i.e., cephalic, trunk, and caudal portions. Following results were made: 1) The primitive hair germ was first noted the 10th week in the face skin as nubbins of mesenchymal cells beneath discrete foci of crowdes, elongated germinative epithelial cells. The developing hair germs and hair pegs were observes at the cephalic portion by 11 weeks. At 15 weeks the hair pegs including hair germs were noted in the trunk skin. The bulbous hair peg stage started at the 16th week in the cephalic portion and at the 18th week in the trunk. 2) Relative number of fetal hairs progressively increase up to 20 weeks of gestation but, thereafter decreased although it was different by the site of the body. 3) The diameter of fetal hair follicles increased with fetal age to the term with slight difference by the portion of body. 4) The developmental process of hair was more rapid in the cephalic portion than the trunk in views of morphologic changes of the hair structures, number and diameter of hair follicles.
Humans

Fournier's gangrene is a rare malignant surgical infection of the perineum, scrotum, and low abdominal areas. It usually occurs after anorectal infections, genitourinary infections, and traumatic injuries. We experienced 12 cases of Fournier's gangrene from 1988 to 1996; the mean age was 60.25 years with an age range of 30 to 83, and the male to female ratio was 11 :1. The most common disease associated with Fournier's gangrene was Diabetes mellitus, 3 cases (27.2%), and the most common cause of the gangrene was perianal abscess, 6 cases (54.5%). We do aggressive surgical debridement combined with a broad spectrum antibiotics therapy on all patients. There were two colostomy cases:one involved severe perianal tissue necrosis; the other was a in rectal cancer perforation. The most commonly cultured organism was E. coli, 5 cases (41.6%). There was one mortality; that patient was died from Adult respiratory distress syndrome and sepsis on the 13th admission days. The average number of admission days were 54.25 days. The mortality from Fournier's gangrene is still high; thus, an important factor in treatment is the suspicion of this disease entity, and examination under anesthesia with aggressive surgical debridement with massive systemic antibiotic therapies is essential.
Abscess ; Anesthesia ; Anti-Bacterial Agents ; Colostomy ; Debridement ; Diabetes Mellitus ; Female ; Fournier Gangrene* ; Gangrene ; Humans ; Male ; Mortality ; Necrosis ; Perineum ; Rectal Neoplasms ; Respiratory Distress Syndrome, Adult ; Scrotum ; Sepsis

Fournier's gangrene is a rare malignant surgical infection of the perineum, scrotum, and low abdominal areas. It usually occurs after anorectal infections, genitourinary infections, and traumatic injuries. We experienced 12 cases of Fournier's gangrene from 1988 to 1996; the mean age was 60.25 years with an age range of 30 to 83, and the male to female ratio was 11 :1. The most common disease associated with Fournier's gangrene was Diabetes mellitus, 3 cases (27.2%), and the most common cause of the gangrene was perianal abscess, 6 cases (54.5%). We do aggressive surgical debridement combined with a broad spectrum antibiotics therapy on all patients. There were two colostomy cases:one involved severe perianal tissue necrosis; the other was a in rectal cancer perforation. The most commonly cultured organism was E. coli, 5 cases (41.6%). There was one mortality; that patient was died from Adult respiratory distress syndrome and sepsis on the 13th admission days. The average number of admission days were 54.25 days. The mortality from Fournier's gangrene is still high; thus, an important factor in treatment is the suspicion of this disease entity, and examination under anesthesia with aggressive surgical debridement with massive systemic antibiotic therapies is essential.
Abscess ; Anesthesia ; Anti-Bacterial Agents ; Colostomy ; Debridement ; Diabetes Mellitus ; Female ; Fournier Gangrene* ; Gangrene ; Humans ; Male ; Mortality ; Necrosis ; Perineum ; Rectal Neoplasms ; Respiratory Distress Syndrome, Adult ; Scrotum ; Sepsis

Subcutaneous granuloma annulare (SGA) is a rare, benign noninfectious histiocytic disease of unknown cause, characterized by necrobiosis of the connective tissue surrounded by infiltrates of histiocytes and lymphocytes. We report a case of SGA in a 49/12-year-old boy. The lesions were five nontender subcutaneous nodules in the parieto-occipital scalp, measuring 1.0 cm to 2.0 cm in diameter. Microscopical examination revealed variable stages of multiple necrobiotic areas, which showed central necrobiosis with palisading histiocytes, involving both the lower dermis and subcutaneous fatty tissue. Electron microscopic findings revealed many histiocytes in the necrobiotic areas with degenerating and necrotic collagen fibers as well as regenerating fibroblasts.