1.A Case of Myasthenia Gravis after Allogeneic Bone Marrow Transplantation.
Joong Seok KIM ; Dong Won YANG ; Seok Beum KO ; Soung Kyeong PARK ; Beum Saeng KIM
Journal of the Korean Neurological Association 2001;19(1):60-61
A 38-year-old woman, affected by chronic myeloid leukemia, received a BMT from his HLA identical brother. A mild acute graft-versus-host disease (GVHD) developed during the first month after the BMT. A typical clinical and electrophysiological feature of myasthenia gravis (MG) developed 3 months after the BMT requiring medication with pyridostigmine and steroids. Laboratory findings including acetylcholine receptor antibody and other autoantibodies were negative. MG is a well-characterized autoimmune disease which, on rare occasions, is also diagnosed as chronic GVHD after BMT. We report a first case of MG during an acute GVHD period. Since the patient had a myasthenic symptom during an acute GVHD period and no evidence of antibody mediated autoimmunity, this is likely to be an immune complication of acute GVHD. (J Korean Neurol Assoc 19(1):60~61, 2001
Acetylcholine
;
Adult
;
Autoantibodies
;
Autoimmune Diseases
;
Autoimmunity
;
Bone Marrow Transplantation*
;
Bone Marrow*
;
Female
;
Graft vs Host Disease
;
Humans
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
Myasthenia Gravis*
;
Pyridostigmine Bromide
;
Siblings
;
Steroids
2.Levosulpiride-induced Parkinsonim.
Joong Seok KIM ; Seok Beum KO ; Si Ryung HAN ; Yeong In KIM ; Kwang Soo LEE
Journal of the Korean Neurological Association 2003;21(4):418-421
The present report discusses four cases of chronic renal failure, which developed symptoms of parkinsonism in response to levosulpiride. The temporal relationship between levosulpiride discontinuation and the disappearance of parkinsonism suggests a causal link. In addition, decreased striatal dopamine transporter bindings assessed by [I-123] IPT SPECT were observed in two patients suggesting that a dopamine blocking agent causes the dysfunction of nigrostriatal dopaminergic neurons and that such injury may be involved in the pathogenesis of drug-induced parkinsonism.
Dopamine
;
Dopamine Plasma Membrane Transport Proteins
;
Dopaminergic Neurons
;
Humans
;
Kidney Failure, Chronic
;
Parkinsonian Disorders
;
Tomography, Emission-Computed, Single-Photon
3.Perioperative Stroke in the Brain and Spinal Cord Following an Induced Hypotension.
Joong Seok KIM ; Seok Beum KO ; Hye Eun SHIN ; Si Ryung HAN ; Kwang Soo LEE
Yonsei Medical Journal 2003;44(1):143-145
A 49-year-old woman presented with stupor and paraplegia following an induced hypotension. The temporal relationship to the induced hypotension and the absence of a clear embolic source on diagnostic tests support a causal association between the hypotensive episode and the ischemic infarct. However, despite the association, a cause-and-effect relationship could not be automatically inferred.
Brain Infarction/*chemically induced
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Cerebrovascular Accident/*chemically induced
;
Female
;
Human
;
Infarction/*chemically induced
;
Middle Aged
;
Preoperative Care/*adverse effects
;
Propanolamines/*adverse effects
;
Spinal Cord/*blood supply
;
Spinal Stenosis/surgery