1.Current Scope and Perspective of Burden of Disease Study based on Health Related Quality of Life.
Seok Jun YOON ; Sang Cheol BAE
Journal of the Korean Medical Association 2004;47(7):600-602
No abstract available.
Quality of Life*
3.Traumatic Disc Injuries and the Iatrogenic Spinal Disability.
Kyeong Seok LEE ; Jae Won DOH ; Seok Mann YOON ; Hack Gun BAE ; Il Gyu YUN
Journal of Korean Neurosurgical Society 2000;29(7):935-939
No abstract available.
4.A Case of Traumatic Ventricular Septal Defect Secondary to Nonpenetrating Chest Trauma.
Won Seok LEE ; In Kyu LEE ; Ki Sik KIM ; Yoon Nyun KIM ; Kwon Bae KIM
Korean Circulation Journal 1987;17(2):381-387
Traumatic ventricular septal defect secondary to nonpenetrating chest trauma is very rare. We present one case of nonpenetrating traumatic ventricular septal defect with the review of the literatures.
Heart Septal Defects, Ventricular*
;
Thorax*
5.Inhibition of Contact Hypersensitivity by PUVA Treatment.
Sung Ho BAE ; Yun Shin CHUNG ; Seok Don PARK ; Hyang Suk YOON ; Hun Taeg CHUNG
Annals of Dermatology 1990;2(1):1-8
Normal C3WHeN strain mice exposed to topical 8inethoxypsomlen plus long wave ultraviolet (PUVA) showed a reduction in contact hypersensitivity, (CH) which was localized to the skin in the area of PUVA treatment (local suppression), whereas systemic PUVA treatment caused diffuse suppression of CH reaction, regardless of the application site of 2,4-dinitro-1-fluorobenzene (DNFB). There seem to be two different mechanisms responsible for CH reduction by PUVA. Local suppression by topical PUVA treatment was thought to be a result of blocking the afferent phase of immune response, it was associated with a lack of CH effector cells in the peripheral lymph nodes and could not be reversed by indomethacin treatment. Diffuse suppression induced by systemic PUVA treatment seemed to be associated with blocking of egress of effector cells from the regional lymph nodes, this depressed CH response was prevented when indomethacin was administered before PUVA treatment.
Animals
;
Dermatitis, Contact*
;
Indomethacin
;
Lymph Nodes
;
Mice
;
Skin
6.Erratum: Development of R packages: ‘NonCompart’ and ‘ncar’ for noncompartmental analysis (NCA)
Hyungsub KIM ; Sungpil HAN ; Yong Soon CHO ; Seok Kyu YOON ; Kyun Seop BAE
Translational and Clinical Pharmacology 2018;26(3):141-141
There are some errors in the published article. The authors would like to make corrections in the original version of the article.
7.A case of primary plasma cell leukemia.
Gai Yoon NAM ; Hwa Young JUNG ; Sung Bae PARK ; Hong Suck SONG ; Dong Seok JEON
Korean Journal of Hematology 1991;26(2):411-417
No abstract available.
Leukemia, Plasma Cell*
;
Plasma Cells*
;
Plasma*
8.Thin Acute Subdural Hematoma: Part 2 : Role of Surgery.
Kyeong Seok LEE ; Hack Gun BAE ; Il Kyu YOON ; Eon LEE
Journal of Korean Neurosurgical Society 1987;16(2):367-376
A retrospective study on 78 cases of surgically treated acute(within 24 hours) subdural hematoma(ASDH) with special reference to the size is presented. The thin ASDH is defined as the hematoma of which thickness is less than 3 mm in the printed CT film(true thickness about 10 mm). 27 cases are the thin ASDH and 51 cases are the not-thin ASDH. Pre-operative Glasgow coma score(GCS1), Postoperative Glasgow coma score(GCS2) and difference between GCS2 and GCS1(GCS2-GCS1) are compared in two groups by student t-tests. The mean GCS2 is worse than the mean GCS1 in the thin ASDH. In the not-thin ASDH, the mean GCS2 is better than the mean GCS1. Futhermore, in the thin ASDH, the mean difference between GCS2 and GCS1 is -1.04("-" means deteriorated after operation). In the not-thin ASDH, it was 0.77. In the thin ASDH, 44.4% is deteriorated(GCS2-GCS1 < or = -2), and 14.8% is improved(GCS2-GCS1 > or = 2). In the not-thin ASDH, 31.4% is improved and 17.6% is deteriorated. Comparisons between the improved cases and the deteriorated cases with various factors are made by chi square tests. Four statistically significant differences are found. The size of hematoma and midline shift are rather smaller in the deteriorated cases, but brain swelling or contused underlying cortex is more commonly observed during operation in the deteriorated cases and craniectomy with or without excision of the contused cortex is more frequently performed. One possible explanation of these results is that surgical decompression on the thin ASDH may cause or exercerbate brain swelling, hemorrhagic contusion or intracerebral hematoma-justlike "popping", thus replacement of the bone flap is difficult. Therefore, the thin ASDH should not be operated immediately, but closely observed in the ICU. If deteriorated, seek for the causing lesion by such as repeated CT scanning, then, treat the causing lesion, often it is not the ASDH itself.
Brain Edema
;
Coma
;
Contusions
;
Decompression, Surgical
;
Hematoma
;
Hematoma, Subdural, Acute*
;
Humans
;
Retrospective Studies
;
Tomography, X-Ray Computed
9.Thin Acute Subdural Hematoma: Part 1 : Clinical Significance.
Kyeong Seok LEE ; Hack Gun BAE ; Il Kyu YOON ; Eon LEE
Journal of Korean Neurosurgical Society 1987;16(2):355-366
A retrospective study on 107 cases of acute(within 24 hours) subdural hematoma(ASDH) with special reference to the size is presented. The thin ASDH is defined as the hematoma of which thickness is less than 3 mm in the printed CT film(true thickness about 10 mm). 45 cases are the thin ASDH and 62 cases are the not-thin ASDH. Age, Glasgow coma score, pupil, CT finding, operation finding, operation method, interval from injury to CT and operation, and outcome at 1 month are compared and analysed with chi square tests. The most significant difference is the high surgical mortality (92.6%) in the thin ASDH despite of the fact that there are no significant bad prognostic factors. This difference might be due to the fact that diffuse brain injury is more commonly associated with the thin ASDH and suggested that the thin ASDH should be managed differently from the not-thin ASDH.
Brain Injuries
;
Coma
;
Hematoma
;
Hematoma, Subdural, Acute*
;
Mortality
;
Pupil
;
Retrospective Studies
10.Regulation of Estrogen Receptor mRNA in Rat Anterior Pituitary Gland.
Min Seok CHUN ; Duck Bae PARK ; Yong Bin PARK ; Kyung Yoon KAM ; Chang Mi KIM ; Kyung Ja YOO
Journal of Korean Society of Endocrinology 1997;12(4):518-527
The estrogen receptor (ER) is present in a wide variety of mammalian tissues and is required for the physiological responses of estrogen, including estrogen-induced tissue-specific changes in gene expression. But most of our knowledge on the regulation of ER mRNA levels comes from in vivo steroid replacement experiments or cancer cell lines that express the ER. Thus the present study was attempted to determine 1) the anterior pituitary ER mRNA levels during rat estrous cycle 2) if estradiol itself directly modulates the ER mRNA levels in cultured rat anterior pituitary using RT-PCR method. In rats with 4 day estrous cycle, the ER mRNA levels in anterior pituitary gland reached to maximum at proestrus 11:00h just before serum estradiol concentration showed the highest. From then, the ER mRNA levels gradually declined during the rest of the proestrus. On the other hands, in cultured rat anterior pituitary cells, the ER mRNA levels were significantly decreased by the treatment of estradiol. These results indicate that the surge of estradiol was proceeded by the increase in pituitary ER mRNA levels during the proestrus and in cultured anterior pituitary cells, estrogen might be involved in the down-regulation of the ER mRNA levels.
Animals
;
Cell Line
;
Down-Regulation
;
Estradiol
;
Estrogens*
;
Estrous Cycle
;
Gene Expression
;
Hand
;
Pituitary Gland, Anterior*
;
Proestrus
;
Rats*
;
RNA, Messenger*