PURPOSE: We compared the first postoperative diagnostic and post-therapy scans of patients who received therapeutic doses of I-131, to investigate the difference in clinical outcomes between patients with concordant findings of diagnostic and post-therapy scans and patients with discrepant (more lesions in post-therapy scan) findings. MATERIALS AND METHODS: The first postoperative diagnostic and post-therapy radioiodine scans of one hundred forty three patients with well differentiated thyroid carcinoma were reviewed. Diagnostic scans were obtained following ingestion of 185 MBq of I-131 and post-therapy scans were obtained after therapeutic dose of 3.7~9.3 GBq of I-131. Successful ablation was defined as no radioiodine uptake on diagnostic radioiodine scan and normal range of serum thyroglobulin level (<10 ng/ml) during serum TSH elevation. RESULTS: Discrepant scan findings were noted in 25 (17.5%) patients. Twenty-two patients (15.4%) showed more lesions in post-therapy scan and 3 patients (2.1%) showed stunning effect. Nine (64.3%) of 14 patients with distant metastasis revealed metastatic lesion(s) only on post-therapy scan. Stunning effect was considered as sublethal damage in 1 patient and treatment by a diagnostic dose in 2 patients. Ablation was achieved in 52.4% (75/143) of all patients. Ablation rate and mean cumulative radioiodine dose were not different statistically between concordant and discrepant groups. CONCLUSION: There were 17.5% difference between diagnostic and post-therapy scan findings when using 185 MBq of I-131 as a diagnostic dose. However, 64.3% of distant metastases were revealed only on post-therapy scan. Ablation rate and mean cumulative radioiodine dose were not different statistically between concordant and discrepant groups. The stunning effect was considered as not only sublethal damage but also treatment by a small diagnostic dose of radioiodine.
Eating ; Humans ; Neoplasm Metastasis ; Reference Values ; Thyroglobulin ; Thyroid Gland* ; Thyroid Neoplasms*

No abstract available.
Defecography* ; Hernia*

No abstract available.

No abstract available.
Fatigue* ; Sciatica*

BACKGROUND : DHEAS, the major circulating adrenal hormone, has been suggested to have a role in many aging related diseases and perhaps in aging itself. But, there is no epidemiologic data of DHEAS in normal adults in Korea. We studied age changes and sex differences in serum DHEAS & its related factors throughout adulthood. METHODS : We administ structured questionnaires to the study subjects. We measured serum DHEAS levels and several biochemical markers (total cholesterol, triglyceride, HDL-cholesterol, glucose etc) in 1.710 healthy men(857) and women (853), aged 17-76 years. We also measured their height, weight, waist & hip circumference and body fat contents with bioimpedance method. We analyzed various variables relating to serum DHEAS levels by using SPSS. Reference data of serum DHEAS level in normal adults were also suggested. RESULTS : The DHEAS concentration peaked at age group blow age of 30 years in man(260.9 microgram/dL). Then mean values declined steadily in both sexes (r=-0.38, p<0.001 in men and r=-0.46, p<0.001 in women). At age group above 70 years, only 30.9% in men & 30.4% in women, when compared with age group below 30 years, was remained. DHEAS concentration were significantly higher in men than women at all age group except age group above 70 years. Average 1.5 times higher concentration in men than in women (at least 1.28 times at age<30 and max 2.00 times at age 60-64). In men, DHEAS had higher mean value in smokers (218.1 vs 199.1 microgram/dL, p<0.05), drinkers (>or=2 times/week, 219.1 vs 185.3 microgram/dL, p<0.01), android type fat distribution group (waist/hip>0.85, 227.1 vs 197.4 microgram/dL) after adjusting age. DHEAS was positively correlated with body mass index (r=0.12, p<0.01). But in women, drinkers (154.3 vs 131.7 microgram/dL, p<0.05) and regular exercise group (146.1 vs 131.6 microgram/dL, p=0.05) had higher mean DHEAS value. There were no significant association between DHEAS and lipid profile (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol) & fasting glucose level in both sex. CONCLUSION : Our data suggest that DHEAS levels may influenced by several sociodemographic factors (e.g. smoking, alcohol, exercise etc) and body mass index. DHEAS level was inversely correlated by age in both sex and men had 1.5 times higher DHEAS values than women. We could not find any association between DHEAS level and lipid profile & fasting blood sugar.
Adipose Tissue ; Adult ; Aging ; Biomarkers ; Blood Glucose ; Body Mass Index ; Cholesterol ; Dehydroepiandrosterone Sulfate* ; Dehydroepiandrosterone* ; Fasting ; Female ; Glucose ; Hip ; Humans ; Korea ; Male ; Surveys and Questionnaires ; Sex Characteristics* ; Smoke ; Smoking ; Triglycerides ; Waist-Hip Ratio

We report a case of cerebral lymphomatoid granulomatosis in a 50-year-old man. Lymphomatoid granulomatosis is an unusual condition which usually presents as a pulmonary manifestation, which occasionally affects the brain, and causes focal inflammatory lesions. Primary cerebral lymphomatoid granulomatosis is very rare. We describe a case of lymphomatoid granulomatosis in the left frontal lobe without pulmonary involvement.
Brain ; Frontal Lobe* ; Humans ; Lymphomatoid Granulomatosis* ; Middle Aged

We present a study on the systemic insults in the early death(within one week) after head injury. The patient population consisted of 192 patients who were admitted to the Soonchunhyang University Chonan Hospital from August 1986 to May 1990 after head injury. We collected clinical features and systemic insults including blood pressure, arterial pH, PaO2, PaCO2, hematocrit, and serum concentration of Na, retrospectively. The most common cause of injury was road traffic accident(77.6%). More than half(57.8%) were under the age of 40 years. The interval from injury to admission was within one hour in 63.2%, and within four hours in 91.4%. The mean interval was 1.8 hours. However, in 154(80.2%) patients, we found the evidence of systemic insults on admission. We found hypotension(ststolic less than 90mmHg) in 22.9%, acidemia(pH<7.35) in 71.3%, arterial hypoxemia(PaO2<60mmHg) in 42.7%, hypercarbia(PaCO2>45mmHg) in 28.7%, anemia(hematocrit<30%) in 13.0%, hyponatremia(Na<135mEq/L) in 10.7%, and hypernatremia(Na>145mEq/L) in 11.2%. These results imply that the prehospital emergency care system useful at the scene of accident and during the transportation is more important than the simple quick-transport-system.
Arterial Pressure ; Chungcheongnam-do ; Craniocerebral Trauma* ; Emergency Medical Services ; Head* ; Hematocrit ; Humans ; Hydrogen-Ion Concentration ; Retrospective Studies ; Transportation

No abstract available.
Brain Injuries* ; Child* ; Glasgow Coma Scale ; Humans

The extent of brain damage is known to be an essential predictive factor in the clinical course of patient with severe head injury. The purpose of the work was to study the usefulness of brain type creatine kinase(CK-BB) as a iochemical index of brain injury. We performed a Tri-check isoenzyme electrophoresis to determine the serum level of CK-BB in 123 patients with head injury. CK-BB isoenzyme was detected in the serum in 24 out of 123 patients with acute brain injury(19.5%). The peak of CK-BB activity ranged from 2 to 85IU/1 and mean value was 21.40+/-21.66IU/1. The activity was higher in patients with diffuse axonal injury, intracerebral hematoma and subdural hematoma than any other cases. The serum CK-BB isoenzyme was more frequently detected in low GCS score cases at admission and these patients had poor outcome than high GCS score cases. High CK-BB activity in serum was associated with poor prognosis, but a low CK-BB activity in serum was not necessarily a good prognostic sign. The presence of the serum CK-BB isoenzyme correlated with admission GCS score and with the ultimate outcome. We conclude that CK-BB level in serum is a reliable marker of cerebral parenchymal injury and may enhance the predictive value of the Glasgow coma scale score when used in conjunction with this indicant.
Brain ; Brain Injuries ; Craniocerebral Trauma* ; Creatine Kinase* ; Creatine* ; Diffuse Axonal Injury ; Electrophoresis ; Glasgow Coma Scale ; Head* ; Hematoma ; Hematoma, Subdural ; Humans ; Prognosis

The extent of brain damage is known to be an essential predictive factor in the clinical course of patient with severe head injury. The purpose of the work was to study the usefulness of brain type creatine kinase(CK-BB) as a iochemical index of brain injury. We performed a Tri-check isoenzyme electrophoresis to determine the serum level of CK-BB in 123 patients with head injury. CK-BB isoenzyme was detected in the serum in 24 out of 123 patients with acute brain injury(19.5%). The peak of CK-BB activity ranged from 2 to 85IU/1 and mean value was 21.40+/-21.66IU/1. The activity was higher in patients with diffuse axonal injury, intracerebral hematoma and subdural hematoma than any other cases. The serum CK-BB isoenzyme was more frequently detected in low GCS score cases at admission and these patients had poor outcome than high GCS score cases. High CK-BB activity in serum was associated with poor prognosis, but a low CK-BB activity in serum was not necessarily a good prognostic sign. The presence of the serum CK-BB isoenzyme correlated with admission GCS score and with the ultimate outcome. We conclude that CK-BB level in serum is a reliable marker of cerebral parenchymal injury and may enhance the predictive value of the Glasgow coma scale score when used in conjunction with this indicant.
Brain ; Brain Injuries ; Craniocerebral Trauma* ; Creatine Kinase* ; Creatine* ; Diffuse Axonal Injury ; Electrophoresis ; Glasgow Coma Scale ; Head* ; Hematoma ; Hematoma, Subdural ; Humans ; Prognosis