No abstract available.
Dermatitis, Atopic*

Nevus sebaceus of Jadassohn is a hamartoma of the skin with the potential to develop benign and malignant neoplasms. This case was characterixed by multiple basal cell epitheliomas, clinically one reddish nodule and multiple pigmented papules, arising in the nevus sebaceus. Histologically, epithelial papillomatous hyperplasia and high-positioned hyperplastic sebaceous glands were found, and tumor nests consisting of basaloid cells with peripheral palisading arrangements were mainly situated in the upper dermis without significant infiltrative growth. We report a rare case of nevus sebaceus with multiple basal cell epitheliomas in the right cheek of a 49-year-old woman.
Carcinoma, Basal Cell* ; Cheek ; Dermis ; Female ; Hamartoma ; Humans ; Hyperplasia ; Middle Aged ; Nevus* ; Nevus, Sebaceous of Jadassohn* ; Sebaceous Glands ; Skin

Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil, used in the treatment of advanced gastrointestinal neoplasms. Mucocutaneous side reactions induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, to our knowledge, there has been no report of concurrent development of eruptions of two types in a patient. We describe a female patient with breast cancer, presented with combined features of acral erythema and hyperpigmentation due to oral tegafur.
Breast Neoplasms ; Erythema* ; Female ; Fluorouracil ; Gastrointestinal Neoplasms ; Humans ; Hyperpigmentation* ; Keratoderma, Palmoplantar ; Tegafur*

Reiters syndrome is an unusual disease characterized a triad of nongonococcal urethritis, conjunctivitis, and arthritis in association with the mircoutaneous lesions of keratoderma blenorrhagica and balarintis circinata. We present herein a case of Reiters syndome combined yiti lung cancer. A 39-year-old man has experienced naigrating polyarthralgia and high fever ilitermittently for about 20 years, Hyperkeratotic erythemnous patches and plaques, which dyeliped about 1 year ago, have aggravated and expanded to the whole body. Histopathologic sections from the plaque on the right forc ari showed characteristic findings including thickened parakeratotic horny layer and spongiform micropustules of Kogoji He was associated with HLA-B27. On the chest X-ray, a thumbtip size mass was incidently found. Chest CT and bone scan findings supported lung cancer and multiele metastases.
Adult ; Arthralgia ; Arthritis ; Conjunctivitis ; Fever ; HLA-B27 Antigen ; Humans ; Lung Neoplasms* ; Lung* ; Neoplasm Metastasis ; Thorax ; Tomography, X-Ray Computed ; Urethritis

Acrokeratoelastoidosis of Costa is a rare palmoplantar keratoderma with autosomal dominant inheritance. It is clinically charaeterized by small, firm, yellowish, shiny, translucent papules occumng over the dorsal hands, the knuckles, and the lateral margine of the palms and soles. Histologically, the characteristic features are hyperkeratosis, aeanthosis, and most strikingly, fragmentation of coarse elastic fibers within the dermis. The lesions usually begin in early childhood and progress slowly. We herein report two familial cases of acrokeratoelastoidosis of Costa showing typical clinic1 and histopathological features.
Dermis ; Elastic Tissue ; Hand ; Keratoderma, Palmoplantar ; Wills*

OBJECTIVE: The present study was undertaken to examine the effects of magnesium ion in the culture medium on the development of mouse fertilized oocytes either before or after pronuclear formation, and to investigate whether the effect of magnesium ion is related with the redistributional change of mitochondria. METHODS: Fertilized oocytes obtained from the oviducts of mice at 15 hr after hCG injection before pronuclear formation (pre-PN) or 21 hr after hCG injection after pronuclear formation (post-PN) were used. The embryos were cultured for 3 days with basic T6 medium-magnesium free and various concentrations of magnesium ion, 0.0, 0.5, 1.0, 2.0, 4.0 or 8.0 mM, respectively. After culture, the developmental stages of embryos and the number of nuclei were evaluated. To observe the effects of magnesium ion on the mitochondrial distribution, fertilized oocytes were collected at 21 hr after hCG injection and cultured for 6 hr with various concentration of magnesium ion. As a control, fertilized oocytes with pronuclei at 27 hr after hCG injection were used. RESULTS: The concentration of magnesium ion to accelerate the in vitro development of mouse fertilized oocytes appeared to be at 2.0 mM for the pre-PN and the post-PN stage embryos. In the mitochondrial redistribution patterns, the embryos cultured in 2.0 mM concentration of magnesium ion showed the highest percentage (22.6%) of distinct perinuclear clustering pattern comparing to other experimental group. CONCLUSION: The effect of magnesium ion may be related to the cytoplasmic redistribution of mitochondria. This relationship seems to connect the developmental competence of preimplantation mouse embryos in vitro. These results can suggest that higher concentration of magnesium ion (2.0 mM) than those of conventional culture medium (0.2~1.2 mM) is more suitable for in vitro culture of preimplantation mouse embryos.
Animals ; Cytoplasm ; Embryonic Structures* ; Magnesium* ; Mental Competency ; Mice* ; Mitochondria ; Oocytes ; Oviducts

Tubular apocrine adenoma is a well-circumscribed intradermal benign tumor with tubular structures showing apocrine differentiation. Most of those cases occur on the scalp in middle aged women. Histologically, tubular structure with apparent apocrine decapitation secretion, cystic dilatation of tubule, and connection with epidermis are the characteristic features of tubular apocrine adenoma. We presented a case of tubular apocrine adenoma that had recurred after incomplete excision. It showed apocrine decapitation secretion histologically and both eccrine and apocrine differentiation on immunohistochemical study.
Adenoma* ; Decapitation ; Dilatation ; Epidermis ; Female ; Humans ; Middle Aged ; Scalp

Ota nevus is a dermal melanocytic harmatoma derived from neural crest melanoblast and involves skin innervated by the trigeminal nerve. Although most cases are clinically apparent at birth or around puberty, acquired lesions in adults have been rarely reported. We reported a 73 year-old Korean man with Ota nevus of the face and scalp that onset in his eighth decade and accompanied multiple solar comedo of the face.
Adolescent ; Adult ; Humans ; Neural Crest ; Nevus of Ota* ; Parturition ; Puberty ; Scalp ; Skin ; Trigeminal Nerve

BACKGROUND: This is the first report of study deals with skin tumors in the Suwon and South Kyungiido area during the past 11 years(1983-1993). OBJECTIVE: We evaluated incidence of tumors, age and sex distribution, and tumor sites. METHODS: We reviewed 1506 cases of skin tumors January 1983 to December 1993, at St. Vincent hospital. RESULTS: l. In the 1506 cases of skin tumors, 1280 cases(85.0%) were benign tumors, and 226 cases(15. 0% ) were malignant tumors. 2. Among the 1280 cases of benign tumors, the most common tumor was epidermal cyst, which followed by lipoma, cavernous hemangioma, pilomatricoma, angiolipoma, neurofibroma and sebor rheic keratosis. 3. Among the 226 cases of malignant tumors, 78 cases of basal cell carcinoma, 59 cases of squamous cell carcinoma, 15 cases of malignant melanoma, 11 cases of actinic keratosis and 10 cases of metastatic carcinoma were found. 4. Among the 10 cases of outaneous metastatic cancer, primary sites were lung(3 cases), kidney(3 cases), breast, urinary bladder, stomach and large intestine. CONCLUSION: The 1506 cases of skin tumors, which were confirmed histologically at the St. Vincent hospital from January 1983 to December 1993, were reviewed.
Angiolipoma ; Breast ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Epidermal Cyst ; Gyeonggi-do* ; Hemangioma, Cavernous ; Incidence ; Intestine, Large ; Keratosis ; Keratosis, Actinic ; Lipoma ; Melanoma ; Neurofibroma ; Pilomatrixoma ; Sex Distribution ; Skin* ; Stomach ; Urinary Bladder

BACKGROUND: This is the first report of study deals with skin tumors in the Suwon and South Kyungiido area during the past 11 years(1983-1993). OBJECTIVE: We evaluated incidence of tumors, age and sex distribution, and tumor sites. METHODS: We reviewed 1506 cases of skin tumors January 1983 to December 1993, at St. Vincent hospital. RESULTS: l. In the 1506 cases of skin tumors, 1280 cases(85.0%) were benign tumors, and 226 cases(15. 0% ) were malignant tumors. 2. Among the 1280 cases of benign tumors, the most common tumor was epidermal cyst, which followed by lipoma, cavernous hemangioma, pilomatricoma, angiolipoma, neurofibroma and sebor rheic keratosis. 3. Among the 226 cases of malignant tumors, 78 cases of basal cell carcinoma, 59 cases of squamous cell carcinoma, 15 cases of malignant melanoma, 11 cases of actinic keratosis and 10 cases of metastatic carcinoma were found. 4. Among the 10 cases of outaneous metastatic cancer, primary sites were lung(3 cases), kidney(3 cases), breast, urinary bladder, stomach and large intestine. CONCLUSION: The 1506 cases of skin tumors, which were confirmed histologically at the St. Vincent hospital from January 1983 to December 1993, were reviewed.
Angiolipoma ; Breast ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Epidermal Cyst ; Gyeonggi-do* ; Hemangioma, Cavernous ; Incidence ; Intestine, Large ; Keratosis ; Keratosis, Actinic ; Lipoma ; Melanoma ; Neurofibroma ; Pilomatrixoma ; Sex Distribution ; Skin* ; Stomach ; Urinary Bladder