1.Cutaneous Ulceration after Injection of Interferon Alpha in a Melanoma Patient.
Jimyung SEO ; Young In LEE ; Jae Won LEE ; Kee Yang CHUNG
Korean Journal of Dermatology 2016;54(3):220-221
No abstract available.
Humans
;
Interferon-alpha*
;
Interferons*
;
Melanoma*
;
Ulcer*
2.Neurobiology of Alzheimer's Disease.
Young Cho CHUNG ; Seung Woo SEO ; Seung Hwan LEE
Journal of the Korean Society of Biological Psychiatry 2001;8(1):62-70
Alzheimer's disease(AD) is associated with a characteristic neuropathology. The major hallmarks of AD are senile plaques(SPs) and neurofibrillary tangles(NFTs). beta-amyloid protein(Abeta) is derived from the proteolysis of amyloid precursor protein(APP) and then converted to SPs. Mature SPs produce cytotoxicity through direct toxic effects and activation of microglia and complement. NFTs are composed of paired helical filaments(PHFs) including abnormally phosphorylated form of the microtubule-associated protein(MAP) tau and increased tau level in cerebrospinal fluid may be observed in most AD. The aggregation of Abeta and tau formation are thought to be a final common pathway of AD. Acetycholine, dopamine, serotonin, GABA and their receptors are associated with AD. Especially, decreased nicotinic acetylcholine receptors(nAChRs) in AD are reported. Genetic lesions associated with AD are mutations in the structural genes for the APP located on chromosome 21, presenilin(PSN)1 located on chromosome 14 and PSN2 located on chromosome 1. Also, trisomy 21, Apo-E gene located on chromosome 19, PMF locus, low density lipoprotein receptor-related protein and alpha-macroglobulin increase risk of AD. In this article, we will review about the neurobioloby of AD and some newly developed research areas.
Acetylcholine
;
Alzheimer Disease*
;
Amyloid
;
Amyloid beta-Peptides
;
Apolipoproteins E
;
Cerebrospinal Fluid
;
Chromosomes, Human, Pair 1
;
Chromosomes, Human, Pair 14
;
Chromosomes, Human, Pair 19
;
Chromosomes, Human, Pair 21
;
Complement System Proteins
;
Dopamine
;
Down Syndrome
;
gamma-Aminobutyric Acid
;
Genetics
;
Lipoproteins
;
Microglia
;
Neurobiology*
;
Proteolysis
;
Serotonin
3.Clinical application of Halo Apparatus
Kwang Yoon SEO ; Young Koo LEE ; Joon Wha CHUNG
The Journal of the Korean Orthopaedic Association 1980;15(4):781-792
Ten cases of unstable spine were treated with various surgical procedures under control of Halo apparatus and following results wen obtained. 1. Six cases of unstable cervical spine were treated with Halo apparatus and were able to obtain solid fusion for permanent stability. 2. Three cases of tuberculous kyphosis were corrected with halo-pelvic hoop on, and were able to obtain mean correction angle of 42 (65%) with little danger. 3. With halo on, staged operations such as anterior and posterior osteotomy, gradual distraction, anterior and posterior fusion of the spine for correcting deformity were carried out securely. 4. Average duration of halo application was eight weeks, no more twelve weeks, and there was no irreversible complication with halo apparatus per se.
Congenital Abnormalities
;
Kyphosis
;
Osteotomy
;
Spine
4.A Clinical Study of Ankle Fractures
Chil Soo KWON ; Kwang Yoon SEO ; Young Koo LEE ; Tae Young CHUNG ; Joon Wha CHUNG
The Journal of the Korean Orthopaedic Association 1978;13(3):399-408
The authors have reviewed 71 cases (70 patients) of the ankle fractures that were treated through the admission in Orthopedic Department, Paik Foundation Hospital, from June 1972 to April 1978. The average duration of the follow-up waa 15 months. The summary of the results were as follows; 1. Of the 71 cases, male was 54 cases and female 17 cases. The average age of the patients was 32. 2. The main cause of the injuries was traffic accident, and the other causes were sliding down and falling from a height, industrial accident, and sports injury in order. 3. By the classification of Lauge-Hansen, the pronation-external rotation and,supination-adduction types were commoner than the other types. 4. Open reduction was performed in 48 cases, and closed reduction in 23 cases. 5. The average duration of the cast immobilization after the closed reduction was 8 weeks, and that of the open reduction was 6 weeks. 6. The result of the treatment was better in those cases of the open reduction than that of, the closed reduction. 7. The good clinical results could be achieved by obtaining the anatomical position of the talus in the mortise and the reduction was achieved more satisfactorily when the key role of the lateral malleolus in complete reduction was well understood.
Accidental Falls
;
Accidents, Occupational
;
Accidents, Traffic
;
Ankle Fractures
;
Ankle
;
Athletic Injuries
;
Classification
;
Clinical Study
;
Female
;
Follow-Up Studies
;
Humans
;
Immobilization
;
Male
;
Orthopedics
;
Talus
5.Bacterial meningitis in newborn and infant: Correlation between organism, CT findings and clinical outcome.
Hye Young CHOI ; Young Seo PARK ; Shi Joon YOO ; Dae Chul SUH ; Young Kyo CHUNG
Journal of the Korean Radiological Society 1993;29(2):312-318
Bacterial meningitis results in significant neurologic dificits despite in spite of much effort in the treatment of the disease. This study was performed to determine the incidence of caustive organisms and to correlate between the organisms and computed tomographic (CT) findings with clinical outcome of bacterial meningitis in newborns and infants. We analyzed the brain CT and clinical records of 15 infants who had been diagnosed as bactrial meningitis by CSF culture. We found that the most common organisms were Group B streptococcus in neonates withou no neurologic complications in all but one and Hemophilus influenza in infants whose clinical outomes were poor in all except one. CT findings related with poor prognosis in this study were cerebral edema, basal cistermal obliteration & enhancement, and cerebral infarction on initial CT and ventriculomegaly on follow-up CT. We concluded that CT diagnosed intracranial complications of bacterial meningitis well and could contributed to better treatment of bacterial meningitis.
Brain
;
Brain Edema
;
Cerebral Infarction
;
Follow-Up Studies
;
Haemophilus
;
Humans
;
Incidence
;
Infant*
;
Infant, Newborn*
;
Influenza, Human
;
Meningitis
;
Meningitis, Bacterial*
;
Prognosis
;
Streptococcus
6.Effect of MK-801 on the Prevention and Treatment of Tardive Dyskinesia.
Jeung Soo SEO ; Young Chul CHUNG ; Keun Young PARK ; Hong Bai EUN ; Young Hyun KIM
Journal of the Korean Society of Biological Psychiatry 1997;4(2):246-250
Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment of TD was studied using a rat model, i.e., vacuous chewing movements(VCM). When comparing VCM scores of Group I(haldol decanoate+MK-801) with that of Group II(hadol decanoate+phosphate buffer saline), late measured VCM scores of former were significantly lower than that of latter, meaning that MK-801 is effective in the prevention of VCM. Furthermore, when MK-801 is also effective in the treatment of VCM. From the above results, it is suggested that glutamatergic hyperfunction might be involved in the development of TD and MK801 could be effective in the prevention and treatment of it.
Dizocilpine Maleate*
;
Mastication
;
Models, Animal
;
Movement Disorders*
7.Two Cases of Thin Basement Membrane Nephropathy presented with Minimal Change Nephrotic Syndrome.
Young Mee SEO ; Jae Gul CHUNG ; En Sil YU ; Jin Yeong JEONG ; Young Seo PARK
Journal of the Korean Pediatric Society 2000;43(7):978-982
Thin basement membrane nephropathy(TBMN) is defined histologically as follows: 1) By light rnicroscopy only minor abnormalities are detected in the glomeruli at most minor mesangial widening. 2) By electron microscopy, diffuse thinning of glomerular basement rnembrane is demonstrated. 3) By immunofluorescence, absence of immunoglobulins and complement components is demonstrated. 4) Alport's syndrome and systemic diseases that may affect the glomerular structure have been excluded. TBMN presented frequently with recurrent or persistent microscopic hematuria. Massive proteinuria such as in nephrotic syndrome rarely occurs in TBMN. We reported two cases of TBMN presented with typical minimal change nephrotic syndrome.
Basement Membrane*
;
Complement System Proteins
;
Fluorescent Antibody Technique
;
Hematuria
;
Immunoglobulins
;
Microscopy, Electron
;
Nephritis, Hereditary
;
Nephrosis, Lipoid*
;
Nephrotic Syndrome
;
Proteinuria
8.A clinical study of Graves' disease in children.
Kee Young PARK ; Ho Kyung CHOI ; Jong Jin SEO ; Young Hun CHUNG
Journal of the Korean Pediatric Society 1991;34(6):812-819
No abstract available.
Child*
;
Graves Disease*
;
Humans
9.A clinical study on the thyroid nodule in childhood.
Yong Ju KIM ; Ki Young CHEONG ; Jong Jin SEO ; Young Hun CHUNG
Journal of the Korean Pediatric Society 1991;34(8):1116-1122
No abstract available.
Thyroid Gland*
;
Thyroid Nodule*
10.Image Standardization and Determination of Gray Level Threshold in the Assessment of the Myocardial Fibrosis by the Computerized Image Analysis.
Nam Young LEE ; Young Sik PARK ; Jin Haeng CHUNG ; Jeong Wook SEO
Korean Journal of Pathology 1998;32(7):494-503
The computerized image analysis is a useful tool for the quantitative assessment of histopathologic findings. In contrast to the usual microscopic examination by pathologists, the computerization should be accompanied with the standardization process of the image. We developed an algorithm to standardize images and to determine the optimal gray level threshold, using a myocardial fibrosis model. Sirius red staining was more convenient for the image analysis than Masson's trichrome staining because of a better contrast with the surrounding structures. To get an optimal measurement, light intensity was standardized at each of the fibrosis, myocardium and background. In this study, the most promising method to determine the degree of fibrosis was that of revising the background without tissue to a gray level of 200, obtaining a green component of the color image, revising the myocardial fiber to 163, and defining a partial ratio as fibrosis index when the gray level threshold was 120. These threshold levels and parameters were determined after drawing the binarization index curves according to the change of the gray level threshold and by the morphological examination of the actual binarization figures overlaid to the original color image. Through these processes we could get a consistent result on the myocardial fibrosis and we expect a similar principle applies when we analyze color images in the histopathologic quantitation by computerized image analysis.
Fibrosis*
;
Myocardium