1.A Case of Natural Killer Cell Leukemia Misdiagnosed as Tuberculous Lymphadenopathy.
A jin LEE ; Sang Gyung KIM ; Chang Ho JEON ; Hun Suk SUH ; Ghil Suk YOON ; An Na SEO
The Korean Journal of Laboratory Medicine 2009;29(3):194-198
Natural killer (NK) cell neoplasms are a group of rare but highly malignant tumors. We report here one case of NK cell leukemia. A 54-yr-old woman presented with a 2-month history of progressive left neck mass. Based on the positive result of tissue PCR for Mycobacterium tuberculosis, she was at first diagnosed with tuberculous lymphadenopathy. After two weeks, she developed generalized lymphadenopathy, hepatosplenomegaly, fever and anemia. Subsequent evaluation was performed including bone marrow aspiration and biopsy. Peripheral blood smear showed leukoerythroblastic features with 31% blasts. Bone marrow was packed with agranular blastoid cells, which were periodic acid-Schiff (PAS) positive and myeloperoxidase (MPO) negative. Immunophenotyping showed that these cells were positive for CD45 and HLA-DR, whereas negative for CD3, CD5, CD7, CD10, CD13, CD14, CD19, CD20, CD22, CD33, CD34, and CD61. Because of the absence of the markers of T-cell, B-cell, and myeloid lineage-specific antigens, we added CD16/56 for the immunophenotyping and the blasts were positive (94%). The tumor cells of biopsied lymph node were only positive for CD56, consistent with NK cell lymphoma. Epstein-Barr virus (EBV) was not detected by RNA in situ hybridization. Culture for M. tuberculosis was negative. Thus this patient was diagnosed with blastic NK cell lymphoma/leukemia involving bone marrow and lymph node.
Antigens, CD45/metabolism
;
Bone Marrow/pathology
;
Female
;
HLA-DR Antigens/metabolism
;
Humans
;
Killer Cells, Natural/immunology/*pathology
;
Leukemia/*diagnosis/immunology/pathology
;
Middle Aged
;
Tuberculosis, Lymph Node/diagnosis
2.Alterations in substance P and CGRP immunoreactivities in the uterus following the induction of inflammation in the rats.
Joong Yol NA ; Ki Hoon CHANG ; Sang Wook YOU ; Soon Choul HONG ; Seo Eun LEE ; Hee Chul HAN
Korean Journal of Obstetrics and Gynecology 2001;44(5):904-910
OBJECTIVE: Recently some reports suggested substance P and CGRP might be important factors for inflammation and hyperalgesia. This study was performed to see whether substance P or CGRP containing nerve fibers might be changed by mustard oil-induced inflammation. METHODS: After injection of mustard oil(5%) into uterine lumen, the uteri were removed and examined with immunohistochemical methods for substance P and CGRP. RESULTS: In the normal uterus, most of the substance P- or CGRP-immunoreactive nerve fibers were observed along the vascular structure and some in the myometrium, only few in the endometrium. Mustard oil did not changed this pattern of nerve fiber distribution but after 48 hrs, the amount of substance P or CGRP immunoreactive nerve fibers were greatly reduced compared with the normal uterus. It is not clear whether the decrease of substance P and CGRP immunoreactive fibers in the uterus was resulted from the depletion of the neuropeptides in the nerve fibers or the retraction of nerve fibers. CONCLUSIONS: These results suggest that the inflammation should cause the change of nerve fibers included in the nociception. This change may attribute the generation of inflammation and inflammatory hyperalgesia.
Animals
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Endometrium
;
Female
;
Hyperalgesia
;
Inflammation*
;
Mice
;
Mustard Plant
;
Myometrium
;
Nerve Fibers
;
Neuropeptides
;
Nociception
;
Rats*
;
Substance P*
;
Uterus*
3.A Case of Melkersson-Rosenthal Syndrome.
Dae Hun PEE ; Yo Won NA ; Ki Young CHANG ; Woo Keun SEO ; Kee Hyoung LEE ; Baik Lin EUN
Journal of the Korean Pediatric Society 2002;45(10):1292-1297
Melkersson-Rosenthal syndrome(MRS) is a rare disorder, having a symptom triad of recurrent facial palsy, orofacial swelling and fissured tongue(lingua plicata). This disorder is usually recurrent or progressive, and monosymptomatic or oligosymptomatic forms have been reported to be more common than classic forms. Generally, MRS occurs in young adults at the end of the second decade of life and incidence of the disease in childhood is known to be very low. Although the clinical manifestation of MRS in children is similar to that in adults, early diagnosis and management is essential to avoid long-lasting functional disorders and psychological problems. We experienced MRS in a 13 year old boy with a history of recurrent facial palsy. We report this case with review of related literature.
Adolescent
;
Adult
;
Child
;
Early Diagnosis
;
Facial Paralysis
;
Humans
;
Incidence
;
Male
;
Melkersson-Rosenthal Syndrome*
;
Young Adult
4.A Case of allergic angitis and granulomatosis with manifestation of pleuritis and pericarditis.
Chang In KIM ; Dong Yul HA ; Young Koo JEE ; Kye Young LEE ; Keun Youl KIM ; Young Hee CHOI ; Na Hae MYUNG ; Pil Weon SEO
Journal of Asthma, Allergy and Clinical Immunology 1998;18(2):316-323
Allergic angitis and granulomatosis is a kind of rare systemic vasculitis, with various manifestations of disease of lung, heart, skin, musculoskeletal system, nervous system and hepatobiliary tract. There was no report of a case with manifestation of pleuritis and pericarditis, while several cases had been reported in Korea. So we here report a case of allergic angitis and granulomatosis with manifestations of pleuritis and pericarditis. The case also showed clinical manifestations of hypereosinophilia, asthma, rhinitis, pulmonary infilterates with eosinophilia and nephritis. Open lung biopsy showed arteritis with heavy infilteration of activated eosinophil in lung, pleura and pericardium. The involvement of heart might cause critical complication leading death. The patients who are supposed as allergic angitis and granulomatosis should be examined for the involvement of heart.
Arteritis
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Asthma
;
Biopsy
;
Eosinophilia
;
Eosinophils
;
Heart
;
Humans
;
Korea
;
Lung
;
Musculoskeletal System
;
Nephritis
;
Nervous System
;
Pericarditis*
;
Pericardium
;
Pleura
;
Pleurisy*
;
Rhinitis
;
Skin
;
Systemic Vasculitis
5.Granular Cell Tumor in the Pituitary Stalk: A Case Report.
Soo Jeong PARK ; Youn Hyuk CHANG ; Na Rae YANG ; Eui Kyo SEO
Brain Tumor Research and Treatment 2015;3(1):60-63
Granular cell tumors (GCTs) have been reported in various tissues, especially the skin and subcutaneous soft tissue of the head and neck. We report a 60-year-old man who presented with intermittent headache and dizziness for 3 months, but no other neurological symptoms. Magnetic resonance imaging (MRI) showed the presence of a mass in the pituitary stalk, and contrast-enhanced MRI showed nodular enhancement in this region. The lesion was completely excised microscopically via a frontotemporal (pterional) approach. On pathological examination, a final diagnosis of a typical GCT was made.
Diagnosis
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Dizziness
;
Granular Cell Tumor*
;
Head
;
Headache
;
Humans
;
Magnetic Resonance Imaging
;
Middle Aged
;
Neck
;
Pituitary Gland*
;
Pituitary Neoplasms
;
Skin
6.Comparison of the Diagnostic Performances of Same-session Endoscopic Ultrasound- and Endoscopic Retrograde Cholangiopancreatography-guided Tissue Sampling for Suspected Biliary Strictures at Different Primary Tumor Sites
Seong Jae YEO ; Chang Min CHO ; Min Kyu JUNG ; An Na SEO ; Han Ik BAE
The Korean Journal of Gastroenterology 2019;73(4):213-218
BACKGROUND/AIMS: Determining the cause of suspected biliary stricture is often challenging in clinical practice. We aimed to compare the diagnostic yields of endoscopic ultrasound-guided tissue sampling (EUS-TS) and endoscopic retrograde cholangiopancreatography-guided tissue sampling (ERCP-TS) in patients with suspected biliary stricture at different primary lesions. METHODS: We enrolled patients who underwent same-session EUS- and ERCP-TS for the evaluation of suspected biliary stricture. Forceps biopsy and/or brush cytology of intraductal lesions and fine-needle aspiration for solid mass lesions were performed during ERCP and EUS, respectively. RESULTS: One hundred and twenty-five patients treated at our institution between January 2011 and September 2016, were initially considered for the study. However, 32 patients were excluded due to loss of follow-up (n=8) and ERCP-TS on the pancreatic duct (n=20) or periampullary lesions (n=4). Of the 93 patients included, 86 had a malignant tumor including cholangiocarcinoma (n=39), pancreatic cancer (n=37), and other malignancies (n=10). Seven patients had benign lesions. EUS-TS had higher rate of overall diagnostic accuracy than ERCP-TS (82.8% vs. 60.2%, p=0.001), and this was especially true for patients with a pancreatic lesion (84.4% vs. 51.1%, p=0.003). CONCLUSIONS: EUS-TS was found to be superior to ERCP-TS for evaluating suspected biliary strictures, especially those caused by pancreatic lesions.
Biopsy
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Biopsy, Fine-Needle
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Cholangiocarcinoma
;
Cholangiopancreatography, Endoscopic Retrograde
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Constriction, Pathologic
;
Diagnosis
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Endosonography
;
Follow-Up Studies
;
Humans
;
Pancreatic Ducts
;
Pancreatic Neoplasms
;
Surgical Instruments
7.Comparison of diagnostic performances of slow-pull suction and standard suction in endoscopic ultrasound-guided fine needle biopsy for gastrointestinal subepithelial tumors
Joon Seop LEE ; Chang Min CHO ; Yong Hwan KWON ; An Na SEO ; Han Ik BAE ; Man-Hoon HAN
Clinical Endoscopy 2022;55(5):637-644
Background/Aims:
Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is integral to the diagnosis of gastrointestinal (GI) subepithelial tumors (SETs). The impact of different EUS-FNB tissue sampling techniques on specimen adequacy and diagnostic accuracy in SETs has not been fully evaluated. This study aimed to compare the diagnostic outcomes of slow-pull (SP) and standard suction (SS) in patients with GI SETs.
Methods:
In this retrospective comparative study, 54 patients were enrolled. Medical records were reviewed for location and size of the target lesion, FNB needle type/size, technical order, specimen adequacy, diagnostic yield, and adverse events. The acquisition rate of adequate specimens and diagnostic accuracy were compared according to EUS-FNB techniques.
Results:
The mean lesion size was 42.6±36.4 mm, and most patients were diagnosed with GI stromal tumor (75.9%). The overall diagnostic accuracies of the SP and SS techniques were 83.3% and 81.5%, respectively (p=0.800). The rates of obtaining adequate core tissue were 79.6% and 75.9%, respectively (p=0.799). No significant clinical factors affected the rate of obtaining adequate core tissue, including lesion location and size, FNB needle size, and final diagnosis.
Conclusions
SP and SS had comparable diagnostic accuracies and adequate core tissue acquisition for GI SETs via EUS-FNB.
8.A case successfully treated with percutaneous drainage of infected hepatic cyst in a patient with adult polycystic kidney disease.
Youn Suk SEO ; Yong Ho CHOI ; Na Ri KIM ; Chang Hee HAN ; Su Jeong CHOI ; Eun Young LEE ; Sae Yong HONG
Korean Journal of Medicine 2002;63(5):562-566
Even though it is a rare complication to have hepatic cyst infection in adult polycystic kidney disease, the patient is expected to be complicated with sepsis or acute cholangitis and die if not treated properly. The typical clinical manifestations of hepatic cyst infection are fever and right upper quadrant abdominal pain. Liver enzyme and serum bilirubin levels may be elevated. The clinical outcome of hepatic cyst infection is better when antibiotic and drainage are performed simultaneously than only antibiotic is used. We experienced a case of infected hepatic cyst from a 58-year-old male patient receiving hemodialysis with autosomal dominant polycystic kidney disease. Due to his persistent fever and leukocytosis during intravenous antibiotic therapy, we performed percutaneous drainage of hepatic cyst. Because the drainage fluid presented leukocytosis and deep yellow color, we diagnosed the case as a hepatic cyst infection. We applied both percutaneous drainage of infected liver cyst and antibiotic and we observed clinical improvement.
Abdominal Pain
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Adult*
;
Bilirubin
;
Cholangitis
;
Drainage*
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Fever
;
Humans
;
Leukocytosis
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Liver
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Male
;
Middle Aged
;
Polycystic Kidney Diseases
;
Polycystic Kidney, Autosomal Dominant*
;
Renal Dialysis
;
Sepsis
9.An Adult Case of Tetralogy of Fallot Accompanied by Multiple Anomalies Including Multidirectional Coronary Artery Fistulas.
Jae Joong LEE ; Jae Young CHO ; Yun Ho LEE ; Byung Hyun LEE ; Chang Gyu PARK ; Hong Seog SEO ; Dong Joo OH ; Jin Oh NA
Korean Circulation Journal 2014;44(3):196-199
Multidirectional coronary artery fistulas (CAFs) are rare in patients with tetralogy of Fallot (TOF). We report an adult patient who underwent open-heart surgery for TOF 24 years before the discussed presentation. Coronary angiogram and cardiac computed tomography revealed multidirectional CAFs originating from the left main coronary artery and draining to the left atrium, pulmonary artery and subphrenic artery. The patient also showed additional congenital anomalies, such as persistent left superior vena cava and right-sided aortic arch.
Adult*
;
Aorta, Thoracic
;
Arteries
;
Arteriovenous Fistula
;
Coronary Vessels*
;
Fistula*
;
Heart Atria
;
Humans
;
Pulmonary Artery
;
Tetralogy of Fallot*
;
Vena Cava, Superior
10.Effect of Teenage Physical Activity on Areal Bone Mineral Density in Healthy Premenopausal Women of Korea.
Yu Na SEO ; Jin A PARK ; Sung Hwan CHO ; Chang Hee HAN ; Su Young LEE ; Sang Keun HAHM ; Young Jun PARK
Journal of the Korean Academy of Family Medicine 2008;29(10):781-787
BACKGROUND: There have been many studies on osteoporosis, which is one of the most important cause of fracture in adults. However, whether moderate physical activity during youth confers lasting benefits for bone is unclear. Thus, we are here concerned with the relation of teenage physical activity and bone mineral density in Korean premenopausal women. METHODS: From March to June 2007, 75 clients who visited a general hospital for medical check-up were enrolled in this study. The subjects reported physical activity for four age periods (12~18, 19~34, 35~49, current) using self reporting questionnaire. And they completed two 3-day food records, had measurements of height and weight, and aBMD assessed using dual-energy X-ray absorptiometry at the lumbar spine (L2-4) and femoral neck. RESULTS: There was a significant relation of teenage physical activity (especially weight bearing physical activity) and aBMD in both sites (lumbar spine r=0.42, P<0.01; femoral neck r=0.33, P<0.01). But the activity during other age periods was not associated with the current aBMD at both sites. CONCLUSION: Our results suggest that moderate physical activity during the teen years appears to have lasting benefits for lumbar spine and femoral neck aBMD in Korean premenopausal women.
Absorptiometry, Photon
;
Adolescent
;
Adult
;
Bone Density
;
Female
;
Femur Neck
;
Hospitals, General
;
Humans
;
Korea
;
Motor Activity
;
Osteoporosis
;
Self Report
;
Spine
;
Weight-Bearing
;
Surveys and Questionnaires