1.Effect of MK-801 on the Prevention and Treatment of Tardive Dyskinesia.
Jeung Soo SEO ; Young Chul CHUNG ; Keun Young PARK ; Hong Bai EUN ; Young Hyun KIM
Journal of the Korean Society of Biological Psychiatry 1997;4(2):246-250
Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment of TD was studied using a rat model, i.e., vacuous chewing movements(VCM). When comparing VCM scores of Group I(haldol decanoate+MK-801) with that of Group II(hadol decanoate+phosphate buffer saline), late measured VCM scores of former were significantly lower than that of latter, meaning that MK-801 is effective in the prevention of VCM. Furthermore, when MK-801 is also effective in the treatment of VCM. From the above results, it is suggested that glutamatergic hyperfunction might be involved in the development of TD and MK801 could be effective in the prevention and treatment of it.
Dizocilpine Maleate*
;
Mastication
;
Models, Animal
;
Movement Disorders*
2.Characteristics of Basal Cell Carcinoma Incompletely Removed by Laser Treatment due to Misdiagnosis as Benign Tumor.
Ji Young KIM ; Young LEE ; Jeung Hoon LEE ; Young Joon SEO
Korean Journal of Dermatology 2018;56(5):349-351
No abstract available.
Carcinoma, Basal Cell*
;
Diagnostic Errors*
3.Periprosthetic Fracture after Total Shoulder Arthroplasty
Nam Su CHO ; Myung Seo KIM ; Jae Woo YANG ; Jeung Hwan SEO ; Dong Won SEO
Journal of the Korean Fracture Society 2020;33(2):118-123
Periprosthetic humeral fractures in patients with total shoulder arthroplasty are rare and difficult to treat. With the significant increase in the number of older patients who have undergone total shoulder arthroplasty in recent years, an increase in the number of periprosthetic shoulder fractures can be estimated. The decisions of treatment have to be taken individually, depending on the stability of the prosthesis, fracture location, and bone quality. On the other hand, there are limited data for treatment guidance and outcomes. This paper reviews the risk factors, classification, treatment, and outcomes of periprosthetic humeral fractures.
4.The Clinical Study of Patients with Cellulitis in the ROK Army.
Koo Il SEO ; Kwang Hyun CHO ; Kea Jeung KIM ; Hee Chul EUN
Korean Journal of Dermatology 1999;37(9):1305-1309
BACKGROUND: Cellulitis is one of the most common infectious skin diseases in primary care units of military service in which personal hygiene could be easily neglected under special circumstances such as outdoor training. OBJECTIVE: This study was designed to elucidate the probable causes of the high incidence rate of cellulitis in military service. METHODS: We prospectively evaluated the clinical findings of 59 patients with cellulitis who were hospitalized in the medical detachment of the 1st Infantry Division of the ROK Army from May, 1995 to April, 1996. RESULTS: The mean age of patients was 21(19-25). Analysing the rank of the patients, the number of recruits was 3(5%), private 26(44%), private first class 17(29%), corporal 11(19%) and sergeant 2(3%). Seventy eight percent of them were included in ranks below corporal. The recurrence rate of cellulitis during the 2 1/2 year follow-up period was only 4%. Skin lesions noted were erythema(100%), tenderness(98%), swelling(98%), local heating(97%), lymphadenopathy(73%), pus (63%), fluctuation(32%), ulcer(27%), lymphangitis(14%), bullae(8%), etc. The most common route of infection was the previous wounds(46%) which allows a portal for invasion of microorganisms. Tinea pedis was also found to be in 39% of patients with cellulitis of the lower leg. The pus culture performed on 7 patients who had not been responsive to primary antibiotics resulted in 6 positive cases of Staphylococcus aureus. CONCLUSION: Considering the ranks of the patients and the routes of infection, we found that the incidence of cellulitis in the military service of the ROK Army could be reduced if more attention would be paid to preventive counterplans for secondary infection and tinea pedis.
Anti-Bacterial Agents
;
Cellulitis*
;
Coinfection
;
Follow-Up Studies
;
Humans
;
Hygiene
;
Incidence
;
Leg
;
Military Personnel
;
Primary Health Care
;
Prospective Studies
;
Recurrence
;
Skin
;
Skin Diseases, Infectious
;
Staphylococcus aureus
;
Suppuration
;
Tinea Pedis
5.Multiple System Atrophy Manifested by Bilateral Vocal Cord Palsy as an Initial Sign.
Yuri SEO ; Soomin JEUNG ; Heeyoung YOON ; Min Chul KIM ; Nah Kyum LEE ; Byeong Zu GHANG ; Sun Ju CHUNG ; Younsuck KOH
Korean Journal of Critical Care Medicine 2015;30(2):123-127
A 71-year-old male initially presented with vocal cord palsy and underwent tracheostomy. After thorough examination, urogenital dysfunction, orthostatic hypotension, and Parkinsonism were found, which led to the diagnosis of multiple system atrophy (MSA). After the tracheostomy, bi-level positive airway pressure ventilation was required during the night due to nocturnal hypoxemia. Night-time hypoxemia is related to central sleep apnea, which is one of the manifestations of MSA. This is the first case of MSA manifested by bilateral vocal cord palsy as an initial sign in Korea. This case supports the notion that MSA should be taken into consideration when vocal cord paralysis is observed.
Aged
;
Airway Obstruction
;
Anoxia
;
Diagnosis
;
Humans
;
Hypotension, Orthostatic
;
Korea
;
Male
;
Multiple System Atrophy*
;
Parkinsonian Disorders
;
Sleep Apnea, Central
;
Tracheostomy
;
Ventilation
;
Vocal Cord Paralysis*
6.A Case of Bilateral Nevus of Ota Associated with Bilateral Nevus of Ito.
Soo Hong SEO ; Jeung Tae JEONG ; Soo Nam KIM ; Young Chul KYE
Korean Journal of Dermatology 2001;39(1):106-108
Benign pigmented lesions derived from dermal melanocytes include the Mongolian spot, the nevi of Ota and Ito, and the blue nevus. The nevus of Ito differs from the nevus of Ota by its location in the supraclavicular, scapular and deltoid regions. It occurs rarely in association with bilateral nevus of Ota. We present a 70 years old male, showing extensive involvement of dermal melanocytic nevi, so called bilateral nevus of Ota associated with bilateral nevus of Ito.
Aged
;
Humans
;
Male
;
Melanocytes
;
Mongolian Spot
;
Nevus of Ota*
;
Nevus*
;
Nevus, Blue
;
Nevus, Pigmented
7.Quality of Life of Alopecia Areata Patients.
Seung Ju BACK ; Young Ok PARK ; Kae Jeung KIM ; Chang Deok KIM ; Young Joon SEO ; Jeung Hoon LEE ; Jang Kyu PARK
Korean Journal of Dermatology 2008;46(5):578-586
BACKGROUND: Hair constitutes an integral part of our self and our self-identity, which is why hair loss may cause a broad range of psychological problems related to our identity. However, the association between quality of life (QOL) in alopecia areata (AA) patients and their clinical characteristics has not yet been investigated in Korea. OBJECTIVE: The purpose of this study is to compare the QOL in patients with AA and healthy controls by using Hairdex scale. The relationship between their QOL and their clinical characteristics will be investigated. METHODS: 102 AA patients and 82 healthy controls were recruited in this study and compared by use of Hairdex. Correlation analysis was performed to examine the relationship between the QOL and the clinical characteristics of patients with AA. RESULTS: The total Hairdex scores and all domain scores, except those of the symptomatic domain, of the Hairdex scales in AA were higher than those of the healthy controls. Clinical characteristics, including the age, disease duration, AA type, AA area, treatment satisfaction, treatment history, anxiety and depression, showed significant correlation with QOL. Of these characteristics, the depression and treatment satisfaction showed strong association with QOL. CONCLUSION: AA can a impair patient's quality of life and has a significant psychological impact.
Alopecia
;
Alopecia Areata
;
Anxiety
;
Depression
;
Hair
;
Humans
;
Quality of Life
;
Weights and Measures
8.A Case of Partial Agenesis of Dorsal Panacreas.
Myoung June KIM ; Gil Dong SEO ; Su Hyung KIM ; Il Doo KIM ; Jeung Ho HEO ; Sung Rac JO
Korean Journal of Gastrointestinal Endoscopy 2001;23(3):197-200
Complete or partial agenesis of dorsal pancreas has been reported in a small number of pediatric and adult patients. A case of partial agenesis of dorsal pancreas was reported. This case was not associated with diabetes mellitus and pancreatic exocrine dysfunction, or abdominal pain. A 37-year-old man with chronic hepatitis B visited to our hospital due to further examination for chronic hepatitis B. Abdominal ultrasonography showed enlarged pancreatic head. Diagnosis was made by endoscopic retrograde cholangiopancreatography and computed tomography. Explor-laparotomy was not done.
Abdominal Pain
;
Adult
;
Cholangiopancreatography, Endoscopic Retrograde
;
Diabetes Mellitus
;
Diagnosis
;
Head
;
Hepatitis B, Chronic
;
Humans
;
Pancreas
;
Ultrasonography
9.Post-Traumatic Cerebral Fat Embolism.
Jeung Mi MOON ; Jeung Ii SO ; Young Kweon KIM ; Jin Ho RYOO ; Tag HEO ; Jeong Jin SEO ; Yong il MIN
Journal of the Korean Society of Emergency Medicine 2001;12(2):170-175
Post-traumatic fat embolism was first reported by Zenker in 1862, Von Bergmann reported the first clinical diagnosis of the fat embolism syndrome in 1873. Fat embolism has been associated with traumatic or non-traumatic disorders. Fat embolization after long bone trauma is probably common as a subclinical event. The diagnosis of fat embolism syndrome is based on the patient's history, is supported by clinical signs of pulmonary, cerebral, and cutaneous dysfunction, and is confirmed by the demonstration of arterial hypoxemia in the abscence of other disorders. Two different mechanisms cause fat to embolize: direct entry of deposit fat into the blood stream and agglutination of endogenous or exogenous plasma fat. MRI can detect a cerebral fat embolism with a higher sensitivity than cerebral CT. We report a case of post-traumatic cerebral fat embolism without pulmonary involvement, and we present a review of the literature. A 16-year girl had a traffic accident and pelvic bone fracture. Forty eight hours later severe trauma become stuporous without a focal neurological deficit. The patient received supportive therapy, and her condition improved throughout her hospital course. She was discharged with good condition after a 30-day hospital stay.
Accidents, Traffic
;
Agglutination
;
Anoxia
;
Diagnosis
;
Embolism, Fat*
;
Female
;
Humans
;
Length of Stay
;
Magnetic Resonance Imaging
;
Pelvic Bones
;
Plasma
;
Rivers
;
Stupor
10.Concordance Rate Between Clinical Impression and Pathologic Diagnosis in Dermatologic Skin Biopsy.
Yong Hee NAM ; Young Jun SEO ; Jeung Hoon LEE ; Jang Kyu PARK ; Jin Man KIM ; Hee Jung KIM
Korean Journal of Dermatology 2004;42(9):1100-1105
BACKGROUND: Skin Biopsy is a equently used diagnostic tool in dermatology and clinical impressions before biopsy may be different with pathologic diagnosis. OBJECTIVES: The purpose of this study was to investigate the concordance rate of clinical impression and pathologic diagnosis. METHODS: Clinical and Pathological studies were done on 559 biopsied skin diseases among 16, 944 out-patients in Dermatologic department of Chungnam University Hospital during the period of 1 year from March, 2002 to February, 2003. RESULTS AND CONCLUSION: The study results are summarized as follows: 1. The most frequently biopsied skin disease group was non-tumor, noninfectious disease (40.8%), followed by benign tumor (37.4%), infectious disease (11.8%), malignant tumor (10.0%). 2. The concordance rate between clinical impression and pathologic diagnosis showed 68.9% in complete agreement and 79.6% in complete and partial agreement. 3. The concordance rate of professor committed cases was 68.8% and that of residents committed cases was 69.1%. 4. The concordance rates among disease groups were highest in malignant tumor (74.6%), then benign tumor (70.8%), non-tumor infectious disease (67.4%) and non-tumor noninfectious disease (65.2%).
Biopsy*
;
Chungcheongnam-do
;
Communicable Diseases
;
Dermatology
;
Diagnosis*
;
Humans
;
Outpatients
;
Skin Diseases
;
Skin*