1.Assessment of Autonomic Function in Alzheimer's Disease and Mild Cognitive Impairment Using Heart Rate Variability.
Han SEO ; Hyun KIM ; Kang Joon LEE
Korean Journal of Psychosomatic Medicine 2013;21(1):55-61
OBJECTIVES: Alzheimer's disease(AD) and mild cognitive impairment(MCI) affect several nervous structures involved with the autonomic nervous system. Association between neuropsychiatric deficits and heart rate variability has been observed. But cardiac autonomic function in AD has been scarcely studied and the results reported are conflicting. We investigated autonomic function in normal control, MCI, AD using heart rate variabil-ity(HRV) technique. METHODS: Time and frequency-domain variability of 5-min R-R interval series was comparatively evaluated in 26 normal control subjects, 22 MCI subjects and 34 AD subjects. Analysis of variance(ANOVA) was used to compare the differences across groups. Correlations between MMSE-KC and HRV components were performed using Pearson's correlation coefficient. RESULTS: No significant difference was observed among the groups in time, frequency-domain analysis of HRV (p>0.05). HRV were not found to be significantly correlated with the degree of cognitive impairment. CONCLUSIONS: There were no differences in HRV with MCI, AD subjects when compared with normal controls. Further investigation is required to use HRV technique as noninvasive parameters of MCI and AD.
Alzheimer Disease
;
Autonomic Nervous System
;
Heart
;
Heart Rate
;
Mild Cognitive Impairment
2.Metastatic Large Cell Neuroendocrine Carcinoma of the Lung Mimicking a Merkel Cell Carcinoma.
Jong Seo LEE ; Won Soon CHUNG ; Dong Hyun KIM ; Jong Seo LEE ; Soo Chan KIM
Annals of Dermatology 2002;14(2):121-123
Large cell neuroendocrine carcinoma (LCNEC) of the lung is a newly recognized entity of pulmonary neuroendocrine carcinoma. Histologically, it is very difficult to differentiate LCNEC from other pulmonary carcinomas and the prognosis is significantly poor. The cutaneous metastasis of LCNEC of the lung shares some features with Merkel cell carcinoma of the skin in light microscopy and yet it is negatively stained with cytokeratin 20. We report a case of cutaneous metastasis of LCNEC of the lung, previously misdiagnosed as squamous cell carcinoma. Our patient showed a poor response to the chemotherapy and also revealed a brain metastasis on follow-up brain CT scan.
Brain
;
Carcinoma, Merkel Cell*
;
Carcinoma, Neuroendocrine*
;
Carcinoma, Squamous Cell
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Keratin-20
;
Lung*
;
Microscopy
;
Neoplasm Metastasis
;
Prognosis
;
Skin
;
Tomography, X-Ray Computed
3.Preliminary Study of Vaginal Cones:A conservative Method of Treating Stress Incontinence.
You Sik LEE ; Jong Hyun KIM ; Ju Tae SEO
Journal of the Korean Continence Society 1997;1(1):60-60
No abstract available.
5.Effect of taping method on ADL, range of motion, hand function & quality of life in post - stroke Patients for 5 weeks.
Keum Soon KIM ; Hyun Mi SEO ; Hae Derk LEE
Korean Journal of Rehabilitation Nursing 2002;5(1):7-17
The purpose of this study was to investigate the effect of taping therapy on activities of daily livings (ADL). hand function and range of motion in poststroke-hemiplegic patients. Sample were selected from 20 poststroke-hemiplegic patients at public health center in the period from September 5 to November 21, 2001. The research design was one group pretest-posttest design. The hemiplegia period of the participants was from one year to five years The pretest and posttest included measuring activity of daily livings(ADL). instrumental activity of daily livings(IADL), hand function, range of motion. quality of life. In this research design, a treatment were to expose taping therapy who were received self-help management program. This self-help management program was cor:1Posed of five sessions and each session had health education on stroke. diet. risk factor. ROM exercise and recreation. 20 patients were treated with kinesio taping(Nippon Sigmax Co.. Ltd.. Benefact(r). width 50mm). Tapes were applied to the Deltoid. Supraspinatus. Infraspinatus, Brachioradialis with paralyzed upper extremity. The taping therapy was performed once a week for 5 weeks. SPSS Win 8.0 was used for the data analysis. The results of this study were as follows: 1) The score of BADL was increased from 30.5 to 33.95 after program, and that was statistically significant(p = .019). 2) The score of IADL was increased from 11.6 to 12.75 after program. but that was statistically insignificant(p = .161). 3) The score of hand function was increased from 17 to 20.35 after program. and that was statistically significant(p = .026). 4) The shoulder's ROM(p=.000) and wrist's ROM(p= .004) were significantly increased. According to the results of this study, taping therapy is effective for improving ADL. hand function. ROM. quality of life. However. this study found no significant differences in IADL Consequently. these findings showed that the taping therapy was effective in improvement of physical aspects(BADL, hand function, upper extremity's ROM) in poststroke-hemiplegic patients.
Activities of Daily Living*
;
Diet
;
Hand*
;
Health Education
;
Hemiplegia
;
Humans
;
Public Health
;
Quality of Life*
;
Range of Motion, Articular*
;
Recreation
;
Research Design
;
Risk Factors
;
Statistics as Topic
;
Stroke*
;
Upper Extremity
6.D-penicillamine Induced Elastosis Perforans Serpiginosa.
Seong Rak SEO ; Dong Ju HYUN ; Hee Jung LEE ; Dong Hyun KIM ; Moon Soo YOON
Korean Journal of Dermatology 2016;54(7):572-574
No abstract available.
Penicillamine*
7.Cutaneous Anaplastic Large T-Cell Lymphoma with Invasion of the Central Nervous System: A Case Report.
Hyun Nam SEO ; Jin Ho SEO ; Cheol Young LEE ; Jihye SONG ; Jong Hyun KIM ; Hyun Woo KIM
Brain Tumor Research and Treatment 2017;5(1):45-48
Anaplastic large T-cell lymphoma (ALCL) encompasses different clinical entities that can be aggressive or localized. Scalp anaplastic lymphoma kinase (ALK)-negative ALCL is considered a localized lymphoma, and usually extends to the regional lymph nodes; intracranial invasion is rare. A 74-year-old woman was diagnosed with scalp ALK-negative ALCL, but did not exhibit invasion of the lymph nodes. Computed tomography and magnetic resonance imaging revealed intracranial masses with bony erosions. We treated the patient using CHOP chemotherapy and achieved short-term regression of the scalp and intracranial lesions. However, the patients ultimately died of pneumonia during the pancytopenic period. Therefore, caution must be exercised when treating scalp ALK-negative ALCL with intracranial invasion.
Aged
;
Central Nervous System*
;
Drug Therapy
;
Female
;
Humans
;
Lymph Nodes
;
Lymphoma
;
Lymphoma, T-Cell*
;
Magnetic Resonance Imaging
;
Meningioma
;
Neurofibromatoses
;
Phosphotransferases
;
Pneumonia
;
Scalp
;
T-Lymphocytes*
8.Papillary cystic neoplasm of pancreas, report of four cases and review of the literature.
Do Yun SEO ; Seung Un BAIK ; Choong Han LEE ; Kyung Hyun CHOI ; Seung Do LEE
Journal of the Korean Cancer Association 1993;25(5):767-772
No abstract available.
Pancreas*
9.A Survey of Discernment and Knowledge Regarding Skin Cancer in General Population.
Hyun Min SEO ; Seung Jae LEE ; Ji Hye PARK ; Ga Young LEE ; Won Serk KIM
Korean Journal of Dermatology 2014;52(1):57-58
No abstract available.
Skin Neoplasms*
;
Skin*
10.Examination of Endoscopic Mucosal Resection of Early Gastric Cancer.
Seung Min LEE ; Seung Won SEO ; Jae Kyu SEONG ; Byung Seok LEE ; Hyun Yong JEONG
Korean Journal of Gastrointestinal Endoscopy 2002;24(3):129-134
BACKGROUND/AIMS: The endoscopic mucosal resection has now been adopted for a useful modality in both curative therapy and accurate diagnosis of early gastric cancer. A retrospective study was done to evaluate the indication and the limitation of endoscopic mucosal resection of early gastric cancer. METHODS: We studied 20 cases of early gastric cancer treated by endoscopic mucosal resection in Chungnam National University Hospital from November, 1995 to July, 1997. RESULTS: 1) The size affected the curability: 83. 3% of lesions less than 2 cm and 50. 0% of those larger than 2 cm were resected completely. 2) The depth of cancer invasion affected the curability: 87. 5% of lesion confined to mucosa were resected completely, while all of submucosal cancers were resected incompletely. 3) Among fourteen cases resected completely, three cases of lesions larger than 2 cm were residual cancer and two of those less than 2 cm were recurred locally. CONCLUSIONS: To be a curative therapy by endoscopic mucosal resection of early gastric cancer, we think that careful selection of the lesion, that is lesion less than 2cm and confined to mucosa, is necessary
Chungcheongnam-do
;
Diagnosis
;
Mucous Membrane
;
Neoplasm, Residual
;
Retrospective Studies
;
Stomach Neoplasms*