Objective To evaluate the clinical efficacy of Shuxuening injection combined with puerarin in the treatment of coronary heart disease patients with unstable angina pectoris .Methods From January 2014 to June 2014,200 patients with coronary heart disease in the People 's Hospital of Huairen County were selected in the research.The patients were randomly divided into two groups according to the digital table ,with 100 cases in each group.The control group was given Shuxuening injection , the observation group received Shuxuening injection combined with puerarin treatment.The treatment time was 15d.The total effective rate,hospitalization time,frequency of angina pectoris,cost of treatment,the incidence of adverse reactions were compared between the two groups .Results After treatment,in the observation group,90 cases were cured,5 cases were effective,5 cases were invalid,the total effective rate was 95%,there was statistically significant difference compared with that in the control group ( χ2＝8.302,P＜0.05).The hospitalization time,times of angina pectoris,cost of treatment in the observation group were (10.15 ±1.20) d,(1.10 ±0.23),(3 458.15 ±210.27) CNY,respectively,which were better than those in the control group (t ＝15.044,12.262,29.177,all P ＜0.05).In the observation group,1 case of fever,1 case of vomiting,the incidence rate of adverse reaction was 2%,there was statistically significant difference compared with that in the control group (χ2＝6.663,P＜0.05).Conclusion Shuxuening combined with puerarin in the treatment of coronary heart disease patients with unstable angina pectoris has significant effect , can improve the indicators , reduce adverse reactions,it is worthy of promotion and application .