Purpose:To evaluate the surgical management of ureteropelvic junction (UPJ) stricture.Method:48 cases of UPJ stricture were treated by dismembered pyeloplasty (Anderson-Hynes) procedure,nephrostomy or ureterostomy along with a double-J multihole stent placement were also established.Results:47 cases of patients obtained satisfactory outcomes after the operation,1 case did after reoperation.Only 1 case had complication in the near future.All patients have been followed up for 8 mouths to 6 years with satisfactory long-term results.Conclusion:Dismembered pyeloplasty (Anderson-Hynes) procedure is the treatment of choice for congenital stricture of UPJ,a double-J stent can serve as internal stent and drainage,nevertheless nephrostomy or ureterostomy is necessary for children.

The ethanol precipitation process of Nauclea officinalis extract was optimized based on the concept of quality by design(QbD). Single factor tests were carried out to determine the levels of test factors. The ethanol volume fraction, pre-ethanol precipitation drug concentration, and ethanol precipitation time were taken as critical process parameters(CPPs). With the comprehensive scores of strictosamide transfer rate and solid removal rate as the critical quality attributes(CQAs), Box-Behnken design was employed to establish the mathematical models and space design between CPPs and CQAs, and the obtained optimal operating space was validated. The optimal operating space included ethanol volume fraction of 65%-70%, pre-ethanol precipitation drug concentration of 22-27 mg·mL~(-1), and ethanol precipitation time of 12 h. Based on the concept of QbD, this study adopted the design space to optimize the ethanol precipitation process of N. officinalis extract, which provided a reliable theoretical basis for the quality control in the production process of N. officinalis preparations. Moroever, this study provided a reference value for guiding the research and industrial production of traditional Chinese medicines.
Drugs, Chinese Herbal ; Ethanol ; Medicine, Chinese Traditional ; Quality Control ; Models, Theoretical