Seminoma is one of the most radiosensitive solid tumors. However, the survival of patients with clinically advanced stages B3 and C disease is poor. Most of the failures of treatment in advanced stage seminoma, however, come from systemic diseases outside radiation fields or are secondary to unrecognized non-seminomatous elements. Therefore adjuvant systemic chemotherapy is essential for proper treatment of three patients. Recently we experienced a case of advanced stage seminoma treated with radical inguinal orchiectomy followed by systemic chemotherapy with good result.
Drug Therapy ; Humans ; Orchiectomy ; Seminoma*

Seminomatous testis tumors are treated highly effectively with irradiation and chemotherapy following orchiectomy according to stage. We report a relatively rare case of seminoma developed in abdominal cryptorchid testis of 35 years old man, which was treated with surgery including the segmental resection of sigmoid colon involved.
Adult ; Colon, Sigmoid ; Drug Therapy ; Humans ; Orchiectomy ; Seminoma* ; Testis*

We have experienced 3 cases of testicular tumors since last 2 years, from June, 1981 to May, 1983. two cases were embryonal Ca. occurred in 22 years old male and 2 1/2 years old male respectively and another one was seminoma case occurred in 33 years old male. All of them were undergone inguinal orchiectomy and the seminoma case has been taken anti-tumor chemotherapy with radiation therapy and still alive. The adult embryonal Ca. case expired 3 months after operation and the child embryonal Ca. case is alive under observation.
Adult ; Child ; Drug Therapy ; Humans ; Male ; Orchiectomy ; Seminoma ; Testicular Neoplasms* ; Young Adult

Incidence of testicular tumor is 1-2% in all male tumor. Various series report that 3.6-11.6% of testicular tumor arise in patient with cryptorchidism or a history of cryptorchidism. But testicular tumors developed in suprapubic ectopic testis were reported rarely. Seminoma is one of the most radiosensitive tumor. However, the survival of patients with advanced tumor is poor. Therefore adjuvant systemic chemotherapy is essential for proper treatment of these patients. Recently we experienced a case of advanced seminoma resulted from suprapubic ectopic testis and treated by orchiectomy, systemic chemotherapy and radiation with good result.
Cryptorchidism ; Drug Therapy ; Humans ; Incidence ; Male ; Orchiectomy ; Seminoma* ; Testicular Neoplasms ; Testis*

Seminoma arising in an abdominally located undescended testis is uncommon, accounting for only 5% of all seminomas. It tends to be relatively advanced at the time of diagnosis and usually treated with surgery followed by radiation and/or chemotherapy. We report a case of 61-year- old man who had a giant seminoma arising in the right testis of bilateral intraabdominal undescended testes with retroperitoneal lymph node metastasis, which was successfully treated with initial BEP chemotherapy. Excision of residual masses revealed complete necrosis of the tumor without viable cancer cells. The patient has been free of recurrence for 5 years after surgery.
Cryptorchidism* ; Diagnosis ; Drug Therapy* ; Humans ; Lymph Nodes ; Male ; Necrosis ; Neoplasm Metastasis ; Recurrence ; Seminoma* ; Testis

To develop a more appropriate therapeutic strategy for treatment of nonpulmonary visceral metastatic testicular seminoma based on the International Germ Cell Consensus Classification, we reviewed the medical records of patients with nonpulmonary visceral metastatic testicular seminoma who were treated over a 20-year period. Only 15 (2.2%) of the 686 cases of testicular seminoma were nonpulmonary visceral metastatic seminoma. The median age of patients was 38 years (range, 22-53 years). Ten (67%) of the patients had an initial diagnosis of supradiaphragmatic or visceral metastatic disease. In addition to nonpulmonary visceral metastasis, all patients had lymph node metastasis as well, the majority of which involved the retroperitoneal lymph nodes. The median and mean progression-free survival durations after chemotherapy for advanced disease were 19 months and 63.7 months, respectively. Six patients (40%) survived, five relapsed after radiation therapy and four died of chemorefractory disease not dependent on the specific regimen. Although the number of cases reviewed in this study was small, we conclude that the choice of chemotherapeutic regimen among the current treatments for nonpulmonary visceral metastatic seminoma of testis primary does not present a different outcome. Therefore, multimodality therapies using new strategies or new agents are well indicated.
Adult ; Antineoplastic Agents, Combined/administration & dosage* ; Bone Neoplasms/secondary ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/drug therapy ; Combined Modality Therapy ; Human ; Lung Neoplasms/secondary ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/drug therapy ; Lymphatic Metastasis ; Male ; Middle Age ; Retroperitoneal Neoplasms/secondary* ; Retroperitoneal Neoplasms/radiotherapy ; Retroperitoneal Neoplasms/drug therapy* ; Retrospective Studies ; Seminoma/secondary* ; Seminoma/radiotherapy ; Seminoma/drug therapy* ; Testicular Neoplasms/pathology*

Follow-up study was made on 14 patients of testicular who were treated at Severance hospital since 1972. The results are summarized as follows: 1. Among the 14 cases of testicular tumors, there were 7 cases of seminoma and 7 cases of nonseminomatous germ cell tumors(3 cases of embryonal cell carcinoma, 1 case of teratoma, 1 case of teratocarcinoma, 1 case of malignant lymphoma and 1 case of reticulum cell sarcoma.) 2. The median survival periods of 7 patients of seminoma was 35 months(range 6 to 113 months). the median survival periods of 7 patients of nonseminomatous germ cell tumor was 25 months (range 7 to 102 months). 3. The clinical stage of patient was stage A in 9, B in 3 and C in 1, The median survival periods of clinical stage A was 27.3 months, B in 51.3 months and C in 8 months. 4. Preoperative evaluation of serum AFB & HCG was made by radioimmunoassay. Only 1 case of non-seminomatous germ cell tumor had elevated serum AFB, but 2 cases of seminoma & 1 case of non-seminomatous germ cell tumor had elevated serum HCG. 5. The average survival periods according to treatment modalities was 40 months in radiation therapy(6 cases of seminoma), 10 months in chemotherapy only(3 cases of non-seminomatous germ cell tumor), 14 months in RPLND(3 cases of non-seminomatous germ cell tumor) and 16 month in RP LND with chemotherapy(2 cases of nonseminomatous germ cell tumor).
Drug Therapy ; Follow-Up Studies* ; Germ Cells ; Humans ; Lymphoma ; Neoplasms, Germ Cell and Embryonal ; Radioimmunoassay ; Reticulum ; Seminoma ; Teratocarcinoma ; Teratoma ; Testicular Neoplasms

Testicular tumors were reported sporadically in Korea. Seminomatous germ cell tumor is the most frequent tumor in the testis and it is treated highly effectively with irradiation and/or chemotherapy according to stage. Herein we report a relatively rare case of seminoma developed in abdominal cryptorchid testis of 28 years old male. which was treated with PVB chemotherapy after cytoreductive surgery. Histopathological examination revealed seminoma of stage II B(T3N2MO) by M.D. Anderson hospital classification Postoperative PVB chemotherapy was performed and the tumor was completely remitted at follow up study for 4 years.
Adult ; Classification ; Cryptorchidism ; Drug Therapy ; Follow-Up Studies ; Humans ; Korea ; Male ; Neoplasms, Germ Cell and Embryonal ; Seminoma* ; Testicular Neoplasms ; Testis*

PURPOSE: Testicular seminomas are radiosensitive and adjuvant radiation therapy after orchiectomy results in long term survival in early stage diseases. Ten year results of radiation therapy after orchiectomy and results of definitive treatment of recurrent seminoma are presented. MATERIALS AND METHODS: Between August 1980 and February 1990, 32 patients with testicular seminomas were treated at the Department of Therapeutic Radiology, Seoul National University Hospital. Twenty-seven patients received radiation therapy after orchiectomy and 5 patients for treatment of recurrent tumors. Two of postoperatively treated patients and 2 of recurrent patients were excluded from the study because of incomplete treatment. Of the patients treated postoperatively. 18 were stage I, 5 were stage IIA, one was stage IIB, and one was stage IIC. There were 4 ipsilateral and 2 contralateral cryptorchids. Preoperatively, b-HCG levels were elevated in 5 patients. Median dose to pelvic and paraaortic lymph node area was 2900 cGy (1550-4550 cGy). One patient with stage I, 4 with stage IIA, and 1 with stage IIB received prophylactic mediastinal irradiation. Two patients were treated with chemotherapy before radiation therapy. Median follow-up period was 104(3-144) months. RESULT: Local control rates were 100% at 5 years after orchiectomy. Five year survival rates were 94.4% in Stage I and 100% in Stage II patients. One patient with stageII disease died 3 months after surgery due to mediastinal metastasis. All the 3 patients treated for recurrent disease are alive without disease. CONCLUSION: Postorchiectomy radiation to the pelvis and para-aortic area remains the treatment of choice for patient with early stage testicular seminoma. Radiation therapy is also an excellent treatment modality for recurrent seminoma.
Drug Therapy ; Follow-Up Studies ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Orchiectomy ; Pelvis ; Radiation Oncology ; Seminoma* ; Seoul ; Survival Rate

A 52-year-old man was presented with a huge left testicular mass and palpable cervical lymphadenopathy with retroperitoneal lymph node enlargement on an abdominal computed tomography. A left radical orchiectomy and an ultrasound-guided neck node biopsy were performed. A pathological examination revealed spermatocytic seminoma with extensive rhabdomyosarcomatous transformation, a condition known to be highly resistant to platinum-based chemotherapy. The patient received four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. A repeat computed tomography revealed a substantial regression consistent with a partial response. Retroperitoneal lymph node dissection was attempted, which revealed rhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved a partial response. Here, we present a first case report of a spermatocytic seminoma with extensive rhabdomyosarcomatous transformation and multiple metastatic lymphadenopathies that showed a favorable response to platinum-based systemic chemotherapy.
Biopsy ; Cisplatin ; Drug Therapy ; Drug Therapy, Combination* ; Etoposide ; Humans ; Ifosfamide ; Lymph Node Excision ; Lymph Nodes ; Lymphatic Diseases ; Middle Aged ; Neck ; Orchiectomy ; Paclitaxel ; Radiotherapy ; Rhabdomyosarcoma ; Seminoma*