1.The Ethanolic Extract of Clitoria ternatea L. Flower Attenuates SMADs and REGs Regulation in Dyslipidemia and Diabetes Mellitus Rat Model
Lusiana DARSONO ; Wahyu WIDOWATI ; Johan LUCIANUS ; Edwin SETIABUDI ; Selonan Susan OBENG ; Shiela STEFANI ; Roro WAHYUDIANINGSIH ; Putu Intan KUSUMA WARDANI ; Dion Samuel MARKUS PAPULUNG ; Hanna Sari WIDYA KUSUMA ; Agung NOVIANTO
Natural Product Sciences 2023;29(4):193-199
Dyslipidemia is a condition of fat metabolism disorders with increased levels of total cholesterol (CHOL), triglycerides (TG), low-density lipoprotein (LDL), and low high-density lipoprotein (HDL). Dyslipidemia is often found in patients with type 2 diabetes mellitus (DMT2) with a higher risk of cardiovascular disease.The extract of butterfly pea (Clitoria ternatea L.) (CTE), exhibits therapeutic action like antioxidant, antiinflammatory and antidiabetic properties. This study examined the antidiabetic potential of CTE in rat models of dyslipidemia and DM. Rats were fed nicotinamide (NA) and streptozotocin (STZ) to induce DMT2 after a 28-day high-fat diet, and the rats were given with CTE at 200, 400, 800 mg/kg body weight (BW), glibenclamide, and simvastatin for 28 days. Suppressor of mothers against decapentaplegic homolog 3 (SMAD3), and SMAD4 were assayed by immunohistochemistry (IHC), regenerating family member 1 alfa (REG1A), REG1B and glucagon gene expression were measured by quantitative reverse transcription polymerase chain reaction (RTqPCR) body weight was measured weekly. CTE at a dose of 800 mg/kg BW was the most active to increase body weight, and decrease SMAD3, SMAD4 protein expression, glucagon, REG1A, REG1B genes expression in dyslipidemia and DM rat model. CTE has potency antidiabetic activities in dyslipidemia and DM rat mode
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