In order to investigate the risk factors of retinopathy of prematurity, we retrospectively reviewed the medical records of 153 premature badies alive and born in our hospital between October 1994 and January 1997. We performed analysis on birth weight, gestational age, duration of oxygen therapy, duration of oxygen therapy more than 40 percent, maxinmum and mean value of oxygen pressute and mean value of carbon dioxide pressure from arterial blood gas analysis in the first 2 weeks, the presence of multiple birth, surfactant therapy, corticosteroid therapy, and intraventricular hemorrhage. In univatiate analysis, birth weight, duration of oxygen therapy, value of oxygen pressure and mean value of carbon dioxide pressure from arterial blood gas analysis in the first 2 weeks, surfactant therapy, and corticosteroid therapy were statistically significant(p<0.05). Howeverm, in stepwise logistic regression analysis to correct the correlations in multiple variables, only birth weight and duration of oxygen therapy were significant risk factors in 95% confidence interval( 0.05, p<0.05). Birth weight, duration of oxygen therapy, and maximum value of oxygen pressure from arterial blood gas analysis in the first 2 weeks were significant risk factors in 90% confidence interval( 0.1, p<0.1).
Birth Weight ; Blood Gas Analysis ; Carbon Dioxide ; Gestational Age ; Hemorrhage ; Humans ; Logistic Models ; Medical Records ; Multiple Birth Offspring ; Oxygen ; Retinopathy of Prematurity* ; Retrospective Studies ; Risk Factors*

Myopia is the most common refractive error throughout the world. Exact and relative etiologies of myopia have not been investigated in detail, although the high prevalence rate of myopia in school children has been well documented. Patients with myopia must endure the physical and financial burden of spectacles or contact lenses throughout their lives. The National Eye Institute estimated that the costs of refractive eye examinations amount to $1 billion annually, with another $1.5 billion spent on eyeglasses each year. The age of onset of myopia is frequently between 5 to 15 years. There has been a dramatic increase in the prevalence rates of myopia over the past decades in Korea and other parts of Asia. The prevalence rate was 8~15% in 1970s, 23% in 1980s, 38% in 1990s, and 46.2% in 2000s in Korean school children. The remarkable increase in Asian school children suggests that life style risk factors during the school periods may have a great impact on the development of school myopia and the overall population prevalence rate of myopia. Because the gene pool has not changed significantly over the past decades, the rapid increase of the prevalence rates of myopia has been attributed to increases in near-work activities and environmental factors. Atropine is effective in preventing myopia by a non-accommodative mechanism. Atropine is a broad-band muscarinic antagonist that binds to all five identified muscarinic receptors. Animal and clinical studies have shown that the M1-selective muscarinic antagonist, pirenzepine, is effective in reducing axial length enlargement and preventing myopia.
Age of Onset ; Animals ; Asia ; Asian Continental Ancestry Group ; Atropine ; Child ; Contact Lenses ; Eyeglasses ; Gene Pool ; Humans ; Korea ; Life Style ; Myopia* ; National Eye Institute (U.S.) ; Pirenzepine ; Prevalence ; Receptors, Muscarinic ; Refractive Errors ; Risk Factors

Forty-six eyes with primary open-angle glaucoma(POAG) and 34 eyes which had previously undergone trabeculectomy for POAG were studied and the postural response of the intraocular pressure(IOP) compared with that of 80 normal eyes, In all groups the increment in IOP occurred when the subject changed from the sitting to the lying position. The pressure increment when changed from the sitting to lying position, averaged 2.4 mmHg in normal eyes, 3.6 mmHg in the group who were treated medically and 3.8 mmHg in the group who had undergone trabeculectomy. There was greater postural response in primary open-angle glaucoma patient compared to normal subject. And also there was no statistically significant difference of postural response in intraocular pressure between the group who were treated medically and the group who had undergone trabeculectomy. It is suggested that abnormal postural response of intraocular pressure in POAG appears to be retained and to be unaffected in those eyes which had undergone trabeculectomy.
Deception ; Glaucoma, Open-Angle* ; Humans ; Intraocular Pressure* ; Trabeculectomy*

Pediatric diseases are important because diagnosis and care for these can be complex. Among them, specific diseases have been associated with ocular involvement. This review presents the ocular manifestations of various pediatric diseases relevant to the clinician. An array of ocular manifestations of hyperthyroidism, hypoparathyroidism, diabetes mellitus, porphyria, cystinosis, mucopolysaccharidosis, Wilson disease, juvenile idiopathic arthritis, systemic lupus erythematosus, Marfan syndrome, Weill-Marchesani syndrome are described. In this review we will review ocular manifestations of systemic pediatric diseases for comprehensive understanding of eye involvement. With this review, authors can recognize the ocular manifestations for diagnosis and management of pediatric systemic diseases.
Arthritis, Juvenile ; Cystinosis ; Diabetes Mellitus ; Diagnosis ; Hepatolenticular Degeneration ; Hyperthyroidism ; Hypoparathyroidism ; Lupus Erythematosus, Systemic ; Marfan Syndrome ; Mucopolysaccharidoses ; Pediatrics ; Porphyrias ; Weill-Marchesani Syndrome

In order to reduce a depth and slope of edge of ablation, the technique using 2 or 3 ablaiton zones has been applied to excimer laser photorefracitve keratectomy (PRK) for high myopic patients. In this study, excimer PRK using 2 zones (5.0mm; 100%, 6.0mm; 70%) or 3 zone (5.0mm; 100%, 5.5mm; 70%, 6.0mm; 50%) were used to each 10 patients having a range of refractive power between -8D and -9.5D randomly and divided into group 1 and group 2, respectively. corneal epithelial healing was delayed in group 2 comparaed to group 1 and the diference of that between group 1 and group 2 were statistical significant (P<0.05). However, the difference of spherical equivalent between group 1 and group 2 was not statistically significant at each follow-up (p>0.05). Uncorrected visual acuities of 20/40 or better were achieved in all patients of both groups at the last postoperrative visit (mean+/-SD, 22+/-3.4 weeks). Spherical equivalent less than 1.0 diopter was achieved in 60% of group 1 and 80% of group 2. As a complication 3 eyes (30%) in group 1 and 1 eye (10%) in group 2 lost 2 lines of best corrected visual acuity and thee was no statistically significant difference in both corneal haziness and patients' complaints between group 1 and group 2. With these results we could find a similar clinical results between excimer PRK using 2 zones and 3 zones by 6 months.
Follow-Up Studies ; Humans ; Lasers, Excimer ; Myopia* ; Photorefractive Keratectomy* ; Visual Acuity

PURPOSE: To study the changes in the amount and isoform pattern of the myosin heavy chain (MyHC) in rabbit extraocular muscle (EOM) fibers after recession. METHODS: Sixteen New Zealand white rabbits were used. Recession surgery was performed on the right superior rectus (SR) muscle by 3 mm in eight rabbits, and performed by 8 mm in other eight rabbits. The left SR muscles were left intact as the control groups. The SR muscles in both eyes were harvested from two rabbits from each recession group at 3 days and 1, 2, and 4 weeks after surgery. The changes in MyHC amount and isoform pattern were analyzed by gel electrophoresis. RESULTS: Total MyHC content decreased from 1 week after surgery in the 3-mm recessed group and from 3 days in the 8-mm group. The type IIb MyHC (MyHCIIb) plus EOM-specific MyHC (MyHCeom) showed similar proportional changes to the total MyHC at the different time points after surgery. CONCLUSIONS: The fast MyHCIIb plus the superfast MyHCeom decreased after EOM recession, and these results appear to be related to the changes in the global layer rather than in the orbital one. This suggests that the global layer might be the fast and the superfast twitch portions of rabbit EOM, which perform the fast saccades in ocular movements.
Electrophoresis ; Eye ; Muscles ; Myosin Heavy Chains ; Myosins ; Orbit ; Protein Isoforms ; Rabbits ; Saccades

PURPOSE: To study the changes in the amount and isoform pattern of the myosin heavy chain (MyHC) in rabbit extraocular muscle (EOM) fibers after recession. METHODS: Sixteen New Zealand white rabbits were used. Recession surgery was performed on the right superior rectus (SR) muscle by 3 mm in eight rabbits, and performed by 8 mm in other eight rabbits. The left SR muscles were left intact as the control groups. The SR muscles in both eyes were harvested from two rabbits from each recession group at 3 days and 1, 2, and 4 weeks after surgery. The changes in MyHC amount and isoform pattern were analyzed by gel electrophoresis. RESULTS: Total MyHC content decreased from 1 week after surgery in the 3-mm recessed group and from 3 days in the 8-mm group. The type IIb MyHC (MyHCIIb) plus EOM-specific MyHC (MyHCeom) showed similar proportional changes to the total MyHC at the different time points after surgery. CONCLUSIONS: The fast MyHCIIb plus the superfast MyHCeom decreased after EOM recession, and these results appear to be related to the changes in the global layer rather than in the orbital one. This suggests that the global layer might be the fast and the superfast twitch portions of rabbit EOM, which perform the fast saccades in ocular movements.
Electrophoresis ; Eye ; Muscles ; Myosin Heavy Chains ; Myosins ; Orbit ; Protein Isoforms ; Rabbits ; Saccades

PURPOSE: Extraocular muscle (EOM) consists of two layers, orbital and global layers which are readily distinguished by their histology. This study was conducted to investigate the changes of histology, myosin heavy chain (MHC), and MHC isoforms of the global and orbital layers of EOM after tenotomy. METHODS: Forty-two New Zealand white rabbits were used. The rectus muscles were harvested at day 3, week 1, week 2, week 4, and week 8 after EOM tenotomy. EOM mass change was measured. The EOM were serially sectioned in coronal plane and stained with Masson's trichrome. The diameters of muscle fibers and cross sectional areas of two layers were measured in the middle of the muscles. Changes of MHC isoforms were also measured using immunohistochemistry. RESULTS: The EOM mass was decreased at all periods of surgery especially at day 3 and week 1, increased maximally at week 8. The diameters of EOM fibers in global layer were decreased at day 3, week 1, and week 2 after EOM tenotomy and increased maximally at week 8. The immunohistochemical stains of fast and slow MHC were weakened in the global layer at week 1 after tenotomy. CONCLUSIONS: EOM changes due to atrophy appeared at day 3, week 1, and week 2 after EOM tenotomy while EOM atrophy was recovered at week 4 and week 8 after the surgery. These changes did not appear on the EOM orbital layer but was shown in EOM global layer. These results were due to the histological and functional differences between the EOM global and orbital layers.
Atrophy ; Coloring Agents ; Immunohistochemistry ; Muscles ; Myosin Heavy Chains ; Orbit ; Protein Isoforms ; Rabbits ; Tenotomy*

PURPOSE: To analyze innervated myotendinous cylinders (IMCs) in the extraocular muscles (EOMs) of normal subjects and strabismic patients. METHODS: The rectus muscles of 37 subjects were analyzed. Distal myotendinous specimens were obtained from 3 normal subjects, 20 patients with acquired strabismus, 11 with infantile strabismus, and from 3 with congenital nystagmus, and were studied by using light microscopy. Some specimens (6 rectus muscles) were also examined by transmission electron microscopy. RESULTS: IMCs were found in the distal myotendinous regions of EOMs. The IMCs of patients with acquired strabismus showed no significant morphological alterations. However, significant IMCs alterations were observed at the distal myotendinous junction of patients with congenital strabismus and congenital nystagmus. CONCLUSIONS: This study supports the notion that IMCs in human EOMs function mainly as proprioceptors, along with effector properties, and a disturbance of ocular proprioceptors plays an important role in the pathogenesis of oculomotor disorder. We suggest that a proprioceptive feedback system should be stimulated and calibrated early in life for the development of binocular vision.
Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Microscopy, Electron, Transmission ; Middle Aged ; Oculomotor Muscles/*innervation/physiopathology/ultrastructure ; Proprioception/physiology ; Strabismus/*pathology/physiopathology ; Young Adult

PURPOSE: To investigate the long-term outcome of patients with partially accommodative esotropia who had augmented surgery. METHODS: Twenty patients with partially accommodative esotropia who underwent augmented surgery were studied retrospectively. The amount of medial rectus recession was measured based on the average of the near deviation with and without spectacle correction. During the follow-up period, the changes of refractive error and angle of deviation were evaluated and the Titmus test and Worth 4-Dot test were performed. The follow-up period was at least 24 months. RESULTS: The average follow-up period was 51.6+/-18.16 months (28~86 months). Seventeen patients showed postoperative deviations of 10 PD or less, one patient was overcorrected, two patients were undercorrected. Sensory tests were performed in 17 patients. Worth 4-dot test resulted in a fusion response at far in 6 patients and at near in 8 patients. Titmus stereotest resulted in positive fly (3000 seconds of arc) in all patients and more than 80 seconds of arc in 3 patients. CONCLUSIONS: Surgical overcorrection in patients with partially accommodative esotropia who had augmented surgery is not worrisome and augmented surgery provides some degrees of stereoacuity and fusion.
Diptera ; Esotropia* ; Follow-Up Studies ; Humans ; Refractive Errors ; Retrospective Studies