OBJECTIVES: This research was intended to verify hepatic effect of simutaneously combined exposure of nickel chloride and cadmium chloride with IPRL(Isolated Perfused Rat Liver) method. METHODS: AST(aspartate aminotransferase), ALT(alanine aminotransferase), LDH(lactate dehydrogenase) and perfusion flow rate were used as the indicator of hepatotoxicity and oxygen consumption rate were used as the indicator of viability. 300(+/-50) g weighted rats were allocated randomly to each group (control group, 50 microM 200 microM separately exposure group of NiC1, and CdC1, simultaneously combined exposure group of NiC1 and CdC1) by 5, totally 35. Buffer which got out of liver was sampled and then biochemical indicator of hepatotoxicity was measured. In order to verify difference among groups, two way repeated ANOVA was used. With comparing mean summation of separate exposure group with mean of simultaneous exposure group, possibility that combined effect could be synergistic effect was verified. RESULTS: AST, ALT, LDH increased in both of separate exposure group and simultaneous exposure group. Perfusion flow rate and oxygen consumption rate decreased but statistically significant difference among groups was not found, In each exposure group, AST, ALT, LDH, oxygen consumption rate of simultaneous exposure group increased more than sum of separate exposure group after any sampling time. CONCLUSIONS: It was found that simultaneous combined effect could be synergistic effect through the biochemical indicator of hepatotoxicity.
Animals ; Cadmium Chloride ; Cadmium* ; Liver ; Nickel* ; Oxygen Consumption ; Perfusion ; Rats*

The effects and roles of social support and stressors (stressful life events and chronic strains) on psychosocial distress were examined in a model with data from a sample of the white-collar workers (N = 416) in Korea. The findings of this study present that mean levels of psychosocial distress were higher' in the female, youth, unmarried and divorced, and low economic status (monthly income). The analysis also shows that, as expected, stressful life and chronic strains as stressors are positively related to occurrence of psychosocial distress, and social support is negatively related to psychosocial distress. Further, the contribution of social support to predicting psychosocial distress is greater in magnitude than that of stressful events, chronic strains, and sociodemographic variables. There is no evidence that social support buffers the impacts of stressors on psychosocial distress, rather social support takes a role of main or direct effects on psychosocial distress. Therefore, the strength of the social support is an important and meaningful strategy to prevent from stress and mental, physical illness.
Adolescent ; Buffers ; Divorce ; Female ; Humans ; Korea ; Life Change Events ; Single Person

No abstract available.
Radionuclide Imaging*

The effects of multiple exposures to pesticides on plasma cholinesterase(ChE) activities and urinary p-nitrophenol excretion were evaluated in rats. Rats were received single dose i.p. with LD50/100(mg/kg) of organophosphorous(OP), organophosphorous-organochroline(OP-OC), organophosphorous-carbamate(OP-CAB), organophosphorous-organoarsenate(OP-OA) pesticides for 4 consecutive days. In repeated administration of pesticides, plasma ChE activities were decreased, but urinary p-nitrophenol were increased after the first injection and then decreased gradually. The recovery rates of ChE activities and p-nitrophenol excretion at 48 hours after the fourth infection were delayed in comparison with the baseline value of 24 hours before the first injection. Statistical significances were found between OP and other groups except OP-OA group after the second injection in plasma ChE activities, but in urinary p-nitrophenol excretion there was statistical significance only between OP and OP-CAB.
Animals ; Cholinesterases* ; Pesticides* ; Plasma* ; Rats*

OBJECTIVES: Cancer is the second most frequent cause of death in Korea. Cancer screening tests can save lives through early detection. Enhancing the cancer screening rate is an important strategy for reducing cancer mortality. The purpose of our study was to evaluate the screening rate and related factors in a rural area. The study investigated relationships between sociodemographic characteristics, several preventive behaviors, and the experience of several cancer screening behaviors. MATERIALS AND METHODS: The study population was recruited voluntarily from the three rural areas(Myen) in Chungju city. The participants completed structured questionnaire from July 21, 1998 to July 26, 1998. RESULTS: The proportions of the study population who had previously received stomach, liver, breast, or cervix cancer screening tests were 24.5%, 18.5%, 27.0%, 59.2% respectively. The 1-year screening rates of stomach, liver, breast, and cervix cancer were 7.4%, 6.8%, 8.6%, 15.6% respectively. In multivariate logistic analysis, some sociodemographic variables, preventive behaviors, or psychological variables were significantly associated with several cancer screening tests. Those who had previously received a stomach cancer screening test were significantly associated with the presence of chronic disease, physician? recommendation, use of alcohol family history of cancer, or previous liver cancer screening test. Those who had previously received a liver cancer screening test were associated with education level, physician? recommendation and previous stomach cancer screening test. Those who had received a cervix cancer screening test were significantly associated with education level, presence of a transportation vehicle, physician? recommendation use of alcohol and previous breast cancer screening test. And those who had received a previous breast cancer screening test were significantly associated with age, marital status, and earlier cervix cancer screening test. CONCLUSION: Based on the results of this study a strategy to promote cancer screening and health objectives at the district level can be made.
Breast ; Breast Neoplasms ; Cause of Death ; Chronic Disease ; Chungcheongbuk-do ; Early Detection of Cancer* ; Education ; Humans ; Korea ; Liver ; Liver Neoplasms ; Marital Status ; Mass Screening ; Mortality ; Surveys and Questionnaires ; Stomach ; Stomach Neoplasms ; Transportation ; Uterine Cervical Neoplasms

OBJECTIVES: This study was done to examine the risk factors for the dyspnea of retired coal miners in Korea. METHODS: Eight hundred and sixteen male workers who took the health examination for retired coal miners in the T hospital were recruited, in this study and their health examination records were employed to assess the risk factors for dyspnea. Both univariate and multiple logistic regression analyses were used to estimate the relationship between known risk factors and the presence of dyspnea. RESULTS: Variables in the univariate analysis, which showed a significant relationship with dyspnea were age(>or=60 years) (OR : 2.20, 95% CI : 1.63-3.00), work duration(>or=2 0 years) (OR : 1.67, 95% CI : 1.24-2.25), profusion of small opacity(>or=1/0) (OR : 1.81. 95% CI : 1.30-2.51), large opacity(>or=A) (OR : 2.19, 95% CI : 1.30-3.70), and the ratio of the distance between the start of the first division of the right and left main pulmonary arteries divided by the transverse diameter of the thorax (cor pulmonale index)(>or=0 . 3 6 ) (OR : 2.37, 95% CI : 1.77-3.17). The multivariate analysis using logistic regression analysis showed age(>or=60 years)(OR : 1.69, 95% CI : 1.28-2.21), smoking amount(>or=1 filters/day) (OR : 1.61, 95% CI : 1.06-2.45), no experience of having quit smoking (OR : 1.40 95% CI : 1.06-1.84), and the cor pulmonale index(>or=0.36)(OR : 1.75, 95% CI : 1.34-2.29) were associated with an increased risk for dyspnea. CONCLUSIONS: These results suggests that the cor pulmonale index is the most significant risk factor in predicting dyspnea in retired coal miners. In addition, this study also revealed that workers aged 60 years or more or smokers were more likely to experience dyspnea as compared to those aged 60 years or less and nonsmokers.
Coal* ; Dyspnea* ; Humans ; Korea* ; Logistic Models ; Male ; Multivariate Analysis ; Pulmonary Artery ; Pulmonary Heart Disease ; Risk Factors ; Smoke ; Smoking ; Thorax

Information on work stress and mental health status of industrial workers was required for optimum staffing and health care management. This study dealt with the relationship between mental health status examined by PSI(psychiatric symptom index) and socio-demographic variables. Especially this study attempted to find relevant determinants of the stress and mental health through multiple stepwise regression analysis based on data obtained from 687 occupational workers. The findings of this study were as follows; Mean scores of symptom dimension were higher in youth, female, more educated, unmarried and divorced, and workers in the noisy condition and short duration in job. And it showed high scores in long duration in job for anxiety; college educated for anger; unmarried for cognitive disturbance. The factors affecting the mean scores of psychiatric symptom index were varied according to the types of symptom; age, sex and duration in job for anxiety; age, sex, living with parent, education and marital status for anger; sex and marital status for depression; noisy condition and sex for cognitive disorder.
Adolescent ; Anger ; Anxiety ; Delivery of Health Care ; Depression ; Divorce ; Education ; Female ; Humans ; Marital Status ; Mental Health* ; Parents ; Single Person

This study was conducted to understand health status by general characteristic, and to find out relationship between social support and worker's health status. Health status was measured using SF-36(Medical Outcome Study Short Form 36), a 36 item self administered Instrument. The finding of this study were as follow; Mean scores of health status by sex were higher in male. The younger worker reported good health on physical functioning and role limitation-physical than did the older worker, but the older worker reported good health on social functioning and mental health. Mean scores of health status were higher in high income and white worker. When the relationship between social support and health status, social functioning, role limitation-emotion, mental health, vitality, general health were significantly related. Therefore we reviewed the evidence that socio-economic condition are associated with health status in this study, and that the strength of the social support was a important to maintain health.
Humans ; Male ; Mental Health ; Outcome Assessment (Health Care)

For the past three decades, considerable attentions have been paid to the search for stressors, stress outcomes and stress modifiers that may reduce the impact of exposure to environmental stressors. Especially medical sociologists and psychologists in medical parts, had an intellectual contribution to the development of stress research. They have presented an excellent opportunity to examine how deeply well-being is affected by the socially structured arrangements of people's lives and by the continuous experiences that result from these arrangements. The predominant concern has been with the role of coping resources, especially social support, coping and so on. The majority of studies report modest but significant positive association between life event levels and physical and mental symtomatology. In particular, the importance of considering psychosocial factors that may modify the effects of stressors on the risk factors for diseases or onset of illness has been emphasized increasingly. Clearly, stress is a complex process in which social, psychological and physiological environments simultaneously affect well-being. This study was performed to document the effect of psychosocial factors such social support, coping, personality traits which had been well known as stress modifiers in the stress process.
Attention ; Psychology* ; Risk Factors

We examined the relationship of high emotional demands and low job control to suicidal ideation among service and sales workers in Korea. A total of 1,995 service and sales workers participated in this study. Suicidal ideation and level of emotional demand and job control were assessed by self-reported questionnaire in 4th Korean National Health and Nutrition Examination Survey. Gender-specific odds ratio (OR) and 95% confidence intervals (95% CI) for suicidal ideation were calculated using logistic regression analysis. The results show that workers who suffered from high emotional demands (OR, 2.07; 95% CI, 1.24-3.45 in men, OR, 1.97; 95% CI, 1.42-2.75 in women) or low job control (OR, 1.96; 95% CI, 1.42-2.75 in men, OR, 1.33; 95% CI, 0.91-1.93 in women) were more likely to experience suicidal ideation after controlling for age, household income, and employment characteristics. The interaction model of emotional demands and job control revealed that workers with high emotional demands and high job control (OR, 1.93; 95% CI, 1.08-3.45 in men, OR, 1.60; 95% CI,1.06-2.42 in women) and high emotional demands and low job control (OR; 4.60, 95% CI;1.88-11.29 in men, OR; 2.78, 95% CI;1.64-4.44 in women) had a higher risk for suicidal ideation compared to those with low emotional demands and high job control after controlling for age, household income, employment characteristics, smoking, alcohol drinking and physical activity habit. These results suggest that high emotional demands in both genders and low job control in men might play a crucial role in developing suicidal ideation among sales and service workers in Korea.
Adult ; Emotions/*physiology ; Employment/economics/*psychology ; Female ; Humans ; Income ; Job Satisfaction ; Logistic Models ; Male ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Republic of Korea ; Risk Factors ; *Suicidal Ideation ; Young Adult