Recently, the oncogene and tumor suppressor gene have been recognized as important factors that is contribute to conversion and progression from normal cell to cnacer one. In the current study, expression rates of c-erbB-2 and p53 oncoprotein were analysed in biopsy tissues of uterine cervix to learn whether the expression rates of p53 and c-erbB-2 were related with prognostic factors. The c-erbB-2 and p53 expression rates of group with invasive cervical carcinoma versus control group were 53.6% vs 17.7% and 51.4% vs 9.7%, respectively. There was stastically significant elevation of e-erbB-2 and p53 oncogene expression in patients with invasive cervical carcinoma(p < 0.01). In comparison of invasive cervical carcinoma with CIN, there were stastically significant differences in p53 expression rates(51.4% vs 28.9%) and c-erbB-2 expression rates(53.6% vs 20.2%) and co-expression rates(31.1% vs 6.8%)(p < 0.01). Also in CIN patients, CIN III group showed statistically significant elevation than CIN I and CIN II group(p < 0.01). Among histologic cell types, the expression rate of p53 was higher in sqamous cell carcinoma than in adenocarcinoma. Except for the expression rate of p53 according to histologic cell type, no statistical difference in expression rates of c-erbB-2 and p53 were found according to age, clinical stage, lymph node metastasis in invasive cervical carcinoma(p > 0.05). In conlcusion, c-erbB-2 and p53 oncoprotein are thought to be possible factors in the carcinogenesis of cervical carcinoma and correlate with progression of it. But continuous analysis and follow up of 5 year survival are desirable to determine the role as prognostic factor and correlation with prognostic factors.
Adenocarcinoma ; Biopsy ; Carcinogenesis ; Cervical Intraepithelial Neoplasia* ; Cervix Uteri ; Female ; Follow-Up Studies ; Genes, Tumor Suppressor ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Oncogenes*

Sir James Paget described the first case of Paget's disease of the breast in 1874, and Du-breuilh, in 1901, reported the first case of extramammary Paget's disease of the vulva. Paget's disease of vulva is a rare intraepithelial neoplasm of uncertain histogenesis. Recently we expe-rienced a case of Paget's disease of the vulva that we present a brief review of literature.
Carcinoma in Situ ; Paget Disease, Extramammary ; Paget's Disease, Mammary ; Vulva*

Between June 1990 and May 1994, 350 laser conization and 200 LEEP were performed. Indications of conization were that directed biopsy specimen was proved CIN II, III or suggests possible microinvasion. In all the cases the procedures were carried out with the patients under local anesthesia. Excisional cone sections(6,600) were evaluated for lesion length,depth and margin status. Invasive cancer was found in 5(1.4%) women of laser group. Operative time was shorter LEEP group than laser group significantly. In laser group, 25(8.3%) women had bleeding that required treatment. One case(0.3%) of pelvic infection and 7 cases(2.3%) of cervical stenosis were observed. In LEEP group, 10(5.3%) women had bleeding, 3(1.6%) patients became cervical stenosis. The diameter of bumed tissue was 0.28mm in laser group and 0.25mm in LEEP group. Success rate were 97.4% in former and 96.3% in later. This study demontrated that CO2 laser conization and LEEP were effective methods for treating high grade cervical intraepithelial neoplasia and added benefit of preserving reproductive function and rule out invasive carcinoma.
Anesthesia, Local ; Biopsy ; Cervical Intraepithelial Neoplasia* ; Conization* ; Constriction, Pathologic ; Female ; Hemorrhage ; Humans ; Lasers, Gas* ; Operative Time ; Pelvic Infection