2.On Improving Donor Lung Usage Rate for Transplantation.
Journal of Korean Medical Science 2017;32(12):1903-1904
No abstract available.
Humans
;
Lung*
;
Tissue Donors*
3.A case of gemcitabine-induced thrombotic microangiopathy in a urothelial tumor patient with a single kidney.
Hyunjin RYU ; Eunjeong KANG ; Seokwoo PARK ; Sehoon PARK ; Kyoungbun LEE ; Kwon Wook JOO ; Hajeong LEE
Kidney Research and Clinical Practice 2015;34(4):237-240
Thrombotic microangiopathy (TMA) is a rare complication of gemcitabine treatment. A 55-year-old man with a history of urothelial cancer underwent right ureteronephrectomy and palliative chemotherapy. The patient presented with dyspnea, generalized edema with foamy urine, and new-onset hypertension with acute kidney injury (AKI). Although AKI with oliguria was evident, thrombocytopenia and hemolytic anemia were not overt. To determine the cause of rapidly progressive azotemia, kidney biopsy was performed despite a single kidney and revealed chronic TMA. Microangiopathic hemolytic anemia and thrombocytopenia developed after renal biopsy. Diagnosed as gemcitabine-induced TMA, gemcitabine cessation and active treatment including steroids, plasmapheresis, and rituximab were carried out, but the patients condition progressed to a dialysis-dependent state. Gemcitabine-induced TMA is often difficult to diagnose because of its variable clinical course. Therefore, heightened awareness of this potentially lethal complication of gemcitabine is essential; renal biopsy may be helpful.
Acute Kidney Injury
;
Anemia, Hemolytic
;
Azotemia
;
Biopsy
;
Drug Therapy
;
Dyspnea
;
Edema
;
Humans
;
Hypertension
;
Kidney*
;
Middle Aged
;
Oliguria
;
Plasmapheresis
;
Steroids
;
Thrombocytopenia
;
Thrombotic Microangiopathies*
;
Rituximab
4.Aphasic Seizure as a Manifestation of Non-Ketotic Hyperglycemia.
Jiyeon KIM ; Sehoon LEE ; Jung Ju LEE ; Byung Kun KIM ; Ohyun KWON ; Jong Moo PARK ; Kyusik KANG
Journal of the Korean Neurological Association 2012;30(4):309-311
Non-ketotic hyperglycemia (NKH) is often related to various types of epileptic seizures. However, aphasic seizures associated with NKH have been rarely reported. A 60-year-old diabetic woman was admitted with language disturbance. She presented recurrent motor aphasia and EEG demonstrated ictal rhythmic discharges initiated from left frontal lobe. The seizures disappeared after introduction of carbamazepine and successful control of serum glucose. She remained seizure-free for three months after discharge. We report a case of NKH, manifested by aphasic seizures.
Aphasia, Broca
;
Carbamazepine
;
Electroencephalography
;
Epilepsy
;
Female
;
Frontal Lobe
;
Glucose
;
Humans
;
Hyperglycemia
;
Middle Aged
;
Seizures
5.Clinical Outcomes of Lung Transplantation: Experience at Asan Medical Center
Yong Ho JEONG ; Sehoon CHOI ; Seung Il PARK ; Dong Kwan KIM ;
The Korean Journal of Thoracic and Cardiovascular Surgery 2018;51(1):22-28
BACKGROUND: Lung transplantation is a life-saving procedure in patients with end-stage lung disease, and is increasingly performed in Korea. METHODS: We retrospectively evaluated the outcomes of patients who received a lung transplant at Asan Medical Center between January 2008 and December 2016. Thirteen of 54 patients experienced multiorgan transplantation; the remaining 41 who received only lung grafts were included. RESULTS: The mean age of the lung transplant recipients was 44.6 years; 27 were men and 14 were women. The most frequent reasons were idiopathic interstitial pneumonia (21 of 41 patients, 51.2%), interstitial lung disease (9 of 41, 22.0%), and bronchiolitis obliterans after bone marrow transplantation (7 of 41, 17.1%). The median waiting time was 47 days, and many patients received preoperative intensive care (27 of 41, 65.9%), ventilator support (26 of 41, 63.4%), or extracorporeal life support (19 of 41, 46.3%). All 41 patients received bilateral lung grafts. Ten deaths occurred (24.3%), including 5 cases of early mortality (12.2%) and 5 cases of late mortality (12.2%). The 1-, 3-, and 5-year survival rates were 78.9%, 74.2%, and 69.3%, respectively. CONCLUSION: Despite a high percentage of patients who required preoperative intensive care, the transplantation outcomes were acceptable.
Bone Marrow Transplantation
;
Bronchiolitis Obliterans
;
Chungcheongnam-do
;
Critical Care
;
Female
;
Humans
;
Idiopathic Interstitial Pneumonias
;
Korea
;
Lung Diseases
;
Lung Diseases, Interstitial
;
Lung Transplantation
;
Lung
;
Male
;
Mortality
;
Retrospective Studies
;
Survival Rate
;
Transplant Recipients
;
Transplants
;
Ventilators, Mechanical
6.Clinical Outcomes of Lung Transplantation: Experience at Asan Medical Center
Yong Ho JEONG ; Sehoon CHOI ; Seung Il PARK ; Dong Kwan KIM ;
The Korean Journal of Thoracic and Cardiovascular Surgery 2018;51(1):22-28
BACKGROUND:
Lung transplantation is a life-saving procedure in patients with end-stage lung disease, and is increasingly performed in Korea.
METHODS:
We retrospectively evaluated the outcomes of patients who received a lung transplant at Asan Medical Center between January 2008 and December 2016. Thirteen of 54 patients experienced multiorgan transplantation; the remaining 41 who received only lung grafts were included.
RESULTS:
The mean age of the lung transplant recipients was 44.6 years; 27 were men and 14 were women. The most frequent reasons were idiopathic interstitial pneumonia (21 of 41 patients, 51.2%), interstitial lung disease (9 of 41, 22.0%), and bronchiolitis obliterans after bone marrow transplantation (7 of 41, 17.1%). The median waiting time was 47 days, and many patients received preoperative intensive care (27 of 41, 65.9%), ventilator support (26 of 41, 63.4%), or extracorporeal life support (19 of 41, 46.3%). All 41 patients received bilateral lung grafts. Ten deaths occurred (24.3%), including 5 cases of early mortality (12.2%) and 5 cases of late mortality (12.2%). The 1-, 3-, and 5-year survival rates were 78.9%, 74.2%, and 69.3%, respectively.
CONCLUSION
Despite a high percentage of patients who required preoperative intensive care, the transplantation outcomes were acceptable.
7.A Case of Coincidental Intrasellar Chordoma and Pituitary Adenoma.
Sehoon PARK ; Hee Sung KIM ; Ki Su PARK ; Taek Kyun NAM ; Yong Sook PARK ; Jeong Taik KWON ; Kyung Tae KIM
Brain Tumor Research and Treatment 2017;5(1):49-52
Although chordomas are midline tumors, primarily intrasellar chordomas are extremely rare. In this report, the authors describe the case of a 68-year-old female with partial abducens nerve palsy in the right eye due to the intrasellar cystic tumor. After endonasal trans-sphenoidal surgery, intraoperative and histopathological findings confirmed the co-occurrence of an entirely intrasellar chordoma and pituitary adenoma. To our knowledge, the present case is the third reported case of an intrasellar chordoma with a pituitary adenoma.
Abducens Nerve Diseases
;
Aged
;
Chordoma*
;
Female
;
Humans
;
Pathology
;
Pituitary Neoplasms*
;
Sella Turcica
8.Two Cases of Distal Renal Tubular Acidosis accompanied by Sjogren's Syndrome.
Eunjeong KANG ; Seokwoo PARK ; Sehoon PARK ; Hajeong LEE ; Eun Young LEE ; Jin Suk HAN ; Kwon Wook JOO
Korean Journal of Medicine 2016;90(3):248-252
Renal tubular acidosis (RTA) is a syndrome characterized by hyperchloremic metabolic acidosis and an inability to excrete highly acid urine, in which the impaired acid excretion is disproportional to the reduction in the glomerular filtration rate. Distal renal tubular acidosis (dRTA) is frequently associated with immune-mediated disease, including Sjogren's syndrome. Sjogren's syndrome is a systemic autoimmune disease that mainly affects exocrine glands, such as the lacrimal and salivary glands, resulting in xerophthalmia and xerostomia. Extraglandular manifestations are frequent and may include renal involvement. Recently, we experienced two cases of renal tubular acidosis in patients with Sjogren's syndrome. The first patient had lower extremity weakness and hypokalemia and the second had nephrocalcinosis. We discuss the frequency and pathogenesis of dRTA in Sjogren's syndrome.
Acidosis
;
Acidosis, Renal Tubular*
;
Autoimmune Diseases
;
Exocrine Glands
;
Glomerular Filtration Rate
;
Humans
;
Hypokalemia
;
Lower Extremity
;
Nephrocalcinosis
;
Salivary Glands
;
Sjogren's Syndrome*
;
Xerophthalmia
;
Xerostomia
9.Characteristics of kidney transplantation recipients over time in South Korea
Sehoon PARK ; Myoungsuk KIM ; Ji Eun KIM ; Kwangsoo KIM ; Minsu PARK ; Yong Chul KIM ; Kwon Wook JOO ; Yon Su KIM ; Hajeong LEE
The Korean Journal of Internal Medicine 2020;35(6):1457-1467
Background/Aims:
Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods:
We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 to 2016, and their demographic and clinical characteristics were collected. The prognostic outcome was graft failure consisted of patient death and death-censored graft failure (DCGF).
Results:
We studied 14,601 KT recipients with median follow-up duration of 3.96 years. The median age at the time of transplantation consistently increased from the past, and proportion of underlying diabetes mellitus prominently increased, reaching 35.6% in 2016. The preemptive KT accounted for approximately 30% of the total transplantation cases. The recipients showed a 10-year cumulative graft survival rate of 71.8%, consisting of 10-year DCGF free survival of 77.6% and patient survival of 92.8%. Age ≥ 20 and < 30 years, age ≥ 70 years, underlying history of diabetes, non-preemptive transplantation, and poor compliance on tacrolimus and mycophenolic acid were the significant risk factors associated with worse DCGF outcome. The economic cost of KT showed prominently increasing trends, reaching a total insured fee of > 60,000,000$ in 2016. However, the expansion was mainly burdened by the national insurance service but not by the patients.
Conclusions
In South Korea, the number of kidney transplantation in elderly or in patients with comorbidities has been increasing. Complex clinical factors were associated with medication compliance and patient prognosis.
10.Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma.
Yoo Ri SON ; Hyeran YANG ; Sehoon LEE ; Jee Young KIM ; Suk Geun HAN ; Kyung Seok PARK
Experimental Neurobiology 2015;24(2):169-172
Balo's concentric sclerosis (BCS) is considered a rare variant of multiple sclerosis, which often mimics an intracranial neoplasm or abscess. We report the case of a 21-year-old woman presenting with BCS while undergoing treatment for pulmonary tuberculosis. Initial brain magnetic resonance imaging (MRI) findings were similar to those for cerebral tuberculoma, multiple metastases, or abscesses. However, the pathognomonic concentric sclerosis characteristic of BCS was seen on MRI. The antemortem confirmatory diagnosis of BCS was made by follow-up MRI and a brain biopsy. It is suggested that BCS should be included in the differential diagnosis of cerebral tuberculoma, especially in developing countries with a high prevalence of tuberculosis.
Abscess
;
Adrenal Cortex Hormones
;
Biopsy
;
Brain
;
Brain Neoplasms
;
Developing Countries
;
Diagnosis
;
Diagnosis, Differential
;
Diffuse Cerebral Sclerosis of Schilder*
;
Female
;
Follow-Up Studies
;
Humans
;
Magnetic Resonance Imaging
;
Multiple Sclerosis
;
Neoplasm Metastasis
;
Prevalence
;
Sclerosis
;
Tuberculoma*
;
Tuberculosis
;
Tuberculosis, Pulmonary
;
Young Adult