1.A Case of Systemic Capillary Leak Syndrome Presenting as Septic Shock.
Sehee JO ; Ahran CHOI ; Seohui LEE ; Miok JO ; Tae Hoon KIM ; Sung Joon JIN ; Young Goo SONG
Korean Journal of Medicine 2014;87(6):761-764
Systemic capillary leak syndrome is a rare disease characterized by life-threatening attacks of reversible plasma extravasation and vascular collapse accompanied by hypotension, hemoconcentration, and hypoalbuminemia. A 36-year-old woman was admitted to this hospital with a fever, along with symptoms consistent with an upper respiratory tract infection and hypotension. Initial laboratory tests revealed several abnormal findings, including an elevated leukocyte count and hematocrit, hypoalbuminemia, and acute renal failure. Here, we report a case of successful treatment of systemic capillary leak syndrome, which can be difficult to distinguish from septic shock.
Acute Kidney Injury
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Adult
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Capillary Leak Syndrome*
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Female
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Fever
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Hematocrit
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Humans
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Hypoalbuminemia
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Hypotension
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Leukocyte Count
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Plasma
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Rare Diseases
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Respiratory Tract Infections
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Shock, Septic*
2.Identification of Coronavirus Isolated from a Patient in Korea with COVID-19
Jeong-Min KIM ; Yoon-Seok CHUNG ; Hye Jun JO ; Nam-Joo LEE ; Mi Seon KIM ; Sang Hee WOO ; Sehee PARK ; Jee Woong KIM ; Heui Man KIM ; Myung-Guk HAN
Osong Public Health and Research Perspectives 2020;11(1):3-7
Following reports of patients with unexplained pneumonia at the end of December 2019 in Wuhan, China, the causative agent was identified as coronavirus (SARS-CoV-2), and the 2019 novel coronavirus disease was named COVID-19 by the World Health Organization. Putative patients with COVID-19 have been identified in South Korea, and attempts have been made to isolate the pathogen from these patients. Upper and lower respiratory tract secretion samples from putative patients with COVID-19 were inoculated onto cells to isolate the virus. Full genome sequencing and electron microscopy were used to identify the virus. The virus replicated in Vero cells and cytopathic effects were observed. Full genome sequencing showed that the virus genome exhibited sequence homology of more than 99.9% with SARS-CoV-2 which was isolated from patients from other countries, for instance China. Sequence homology of SARS-CoV-2 with SARS-CoV, and MERS-CoV was 77.5% and 50%, respectively. Coronavirus-specific morphology was observed by electron microscopy in virus-infected Vero cells. SARS-CoV-2 was isolated from putative patients with unexplained pneumonia and intermittent coughing and fever. The isolated virus was named BetaCoV/Korea/KCDC03/2020.
3.Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors.
Wonjin KIM ; Yoonjung CHUNG ; Se Hwa KIM ; Sehee PARK ; Jae Hyun BAE ; Gyuri KIM ; Su Jin LEE ; Jo Eun KIM ; Byeong Woo PARK ; Sung Kil LIM ; Yumie RHEE
Endocrinology and Metabolism 2015;30(1):58-64
BACKGROUND: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. METHODS: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 microg calcitriol (n=46), or placebo (n=44) for 6 months. RESULTS: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8+/-13.6 pmol/L vs. 23.1+/-4.8 pmol/L, P<0.05). Baseline sclerostin levels positively correlated with either lumbar spine or total hip bone mineral density only in postmenopausal women (r=0.218 and r=0.233; P<0.05, respectively). Serum sclerostin levels increased by 39.9%+/-10.2% 6 months after AI use in postmenopausal women; however, no difference was observed between the alendronate and placebo groups (39.9%+/-10.2% vs. 55.9%+/-9.13%, P>0.05). CONCLUSION: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.
Alendronate
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Aromatase Inhibitors*
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Bone Density
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Breast Neoplasms
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Calcitriol
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Estrogens*
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Female
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Hip
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Humans
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Osteocytes
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Osteogenesis
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Osteoporosis
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Spine
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Steroids
4.Associations between Atopic Dermatitis and Risk of Gastric Cancer: A Nationwide Population-based Study
Sehee JO ; Tae Jun KIM ; Hyuk LEE ; Yang Won MIN ; Byung Hoon MIN ; Jun Haeng LEE ; Hee Jung SON ; Poong Lyul RHEE ; Sun Young BAEK ; Sun Woo KIM ; Jae J KIM
The Korean Journal of Gastroenterology 2018;71(1):38-44
BACKGROUND/AIMS: Epidemiologic and clinical data indicate that allergies may be associated with reduced risks for several cancers; however, to date, only a few studies have examined the associations between allergies and gastric cancer. This study aimed to examine the associations between allergies and gastric cancer using a large population-based dataset. METHODS: This cross-sectional study obtained data from the Korea National Health and Nutrition Examination Survey between 2010 and 2014, involving a total of 24,089 participants. The associations between allergies and gastric cancer were analyzed using univariable and multivariable logistic regression analyses with complex sampling, while adjusting for confounding factors that included age, sex, body mass index, smoking status, alcohol intake, and level of education. RESULTS: Multivariable logistic regression analyses that were adjusted for the potential confounders determined that a history of allergic diseases tended to be associated with reduced risk of gastric cancer; however, this relationship was not statistically significant (any allergy: odds ratio [OR], 0.62; 95% confidence interval [CI], 0.34-1.12; atopic dermatitis: OR, 0.34; 95% CI, 0.50-1.72; allergic rhinitis: OR, 0.71; 95% CI, 0.34-1.46; asthma: OR, 0.44; 95% CI, 0.15-1.29). Multivariable analysis showed that a history of atopic dermatitis was associated with reduced risk of gastric cancer in men (OR, 0.16; 95% CI, 0.03-0.75). CONCLUSIONS: This findings of this study suggest that individuals with allergies tend to have a reduced risk of gastric cancer, without a statistically significant association. Furthermore, atopic dermatitis was associated with reduced risk of gastric cancer, particularly in men.
Asthma
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Body Mass Index
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Cross-Sectional Studies
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Dataset
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Dermatitis, Atopic
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Education
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Humans
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Hypersensitivity
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Korea
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Logistic Models
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Male
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Nutrition Surveys
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Odds Ratio
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Rhinitis, Allergic
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Smoke
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Smoking
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Stomach Neoplasms