1.A Case of Generalized Syringoma.
Jong Suk LEE ; Eun Jung CHUNG ; See Yong PARK
Korean Journal of Dermatology 1984;22(4):431-434
We present a case of generalized syringoma in a 12-year-old healthy girl. The patient has numerous skin colored or yellowish papules on the face, neck, anterior chest, axillae and abdomen. She has a family history of eyelid syringoma occuring in her mother and maternal grandmother. Diagnosis was confirmed by characteristic histopathologic findings.
Abdomen
;
Axilla
;
Child
;
Diagnosis
;
Eyelids
;
Female
;
Humans
;
Mothers
;
Neck
;
Skin
;
Syringoma*
;
Thorax
2.Clinical and Histopathological Observation on Acquired Melanocytic Nevus ( 1975 ~ 1985 ).
Jae Chul LEE ; Eun Jung CHYUNG ; See Ryong PARK
Korean Journal of Dermatology 1988;26(6):874-878
This clinical and histopatholgical study was performed with 149 cases of acquired melanocyticnevi, which were obtained as surgical specimens from 1975 to 1985 at Depa.rtment of Clinical Pathology, Seoul Red Cross Hopital. The results were as follows: 1) Histologic subdivision of melanocytic nevus into junctional(,J), IJC, compound (C,"), ICI, and intradermal(I) is used. IJC is a lesion in an intermediate state between ,junctional and compound nevus, and ICI, between compound and intradermal nevus. 2) The age distribution of the excisional melanocytic nevus peaks during the third decade of life, with 47% of patients between 21 40 year old of age. 3) Of l49 specimens with excisional melanocytic nevus, the number of junctional, IJC, compound, ICI and intradermal nevus were 17, 4, 21, 32 and 75 in each group And so, it is likely that evolution of the melanocytic nevus have an increased opportunity for surgical excision. 4) Among the 17 cases of junctional nevus, one case is found in 5th and the other one in 7th decade. 5) In distvibution of melanocytic nevus, head including face is the most common site among the body area and then trunk, neck, lower and upper extremity in decreasing orders.
Adult
;
Age Distribution
;
Head
;
Humans
;
Neck
;
Nevus
;
Nevus, Intradermal
;
Nevus, Pigmented*
;
Pathology, Clinical
;
Red Cross
;
Seoul
;
Upper Extremity
3.A Case of PUVA Lentigo.
Jong Suk LEE ; Eun Jung CHYUNG ; See Yong PARK
Korean Journal of Dermatology 1985;23(3):369-372
Generalized distinct hyperpigrnented macules developed at 2. 7 years after starting photochemotherapy(psoralen and UVA) in a 66-year-old psoriatic male patient. The histopathologic feature of this macule was characterized as a lentiginous p roliferation. The significance and long term course of PUVA lentigo are still unknown. So, we will further monitor this patient continually for melanocytic dysplasias, including melanoma.
Aged
;
Humans
;
Lentigo*
;
Lichen Planus
;
Male
;
Melanoma
;
Mouth Mucosa
4.A Case of Familial Benign Chronic Pemphigus.
Jong Suk LEE ; Eun Jung CHUNG ; See Yong PARK
Korean Journal of Dermatology 1984;22(6):639-642
We present a case of familial benign chronic pemphigus in 50-year-old male patient who had had recurrent oozing, macerated and eroded skin lesions on the groin and scrotum for 20 years. At first, we diagnosed his case as scrotal eczema and/or intertrigo, but after repeated recurrance, it was confirmed as above disease by characteristic histopathologic findings.
Cytochrome P-450 CYP1A1
;
Eczema
;
Groin
;
Humans
;
Intertrigo
;
Male
;
Middle Aged
;
Pemphigus, Benign Familial*
;
Scrotum
;
Skin
5.A Case of Eccrine Angiomatous Hamartoma.
Jae Chul LEE ; Jin Joo PARK ; Eun Chyung JUNG ; See Ryong PARK
Korean Journal of Dermatology 1988;26(2):255-258
Eccrine angiomatous hamartoma or sudoriparous angioma is a hamartoma in which histologically, hyperplasia of eccrine sweat apparatus and vascular elements is present in the same lesion and clinically has tenderness and hyperhidrosis over the lesion. We present a case of eccrine angiomatous hamartoma developed on the medial side of the right knee in a 5-year-old female patient.
Child, Preschool
;
Female
;
Hamartoma*
;
Hemangioma
;
Humans
;
Hyperhidrosis
;
Hyperplasia
;
Knee
;
Sweat
6.Idiopathic Progressive Atrophoderma of Pasini and Pierini.
Jin Joo PARK ; Jae Chul LEE ; Eun Jung CHUNG ; See Yong PARK
Korean Journal of Dermatology 1987;25(1):141-145
We report a case of idiopathic progressive atrophoderma of Pasini and Pierini in which the characteristics atrophic paches developed on the lumbar area and new lesions have a zosteriform distribution in lumbar area, scapular area and heels. This 32-year-old male patient who has had above lesions for 15 yeara, was first seen in September 1985. Histologic findings of this patient are atrophy in epidermis, tightly packed collagen bundles and moderatly decreased elastic fibers in the dermis. We observed this patient without treatment and 5 month later, lesions did not progress.
Adult
;
Atrophy
;
Collagen
;
Dermis
;
Elastic Tissue
;
Epidermis
;
Heel
;
Humans
;
Male
7.Flow Cytometric Analysis of the Effects of Resveratrol on the Survival of Human Tennon's Capsule Fibroblasts.
See Eun LEE ; Keun Hae KIM ; Jae Woo KIM
Journal of the Korean Ophthalmological Society 2015;56(8):1268-1273
PURPOSE: Resveratrol exerts cytoprotective or cytotoxic effects according to cell type. This study was performed to evaluate the effects of resveratrol on the survival of cultured human Tenon's capsule fibroblasts (HTFBs). METHODS: Primarily cultured HTFBs were exposed to 0, 10, or 100 microM resveratrol for 3 days. Cellular survival was assessed using the MTT assay and degree of apoptosis was analyzed with flow cytometry using annexin-V/propidium iodide double staining. RESULTS: Resveratrol decreased the survival of HTFBs after exposure to 10 microM (p = 0.04). In flow cytometric analysis, 10 microM resveratrol did not affect the degree of apoptosis (p = 0.89), but 100 microM resveratrol increased the degree of apoptosis (p = 0.003). Both 10 and 100 microM resveratrol did not affect the degree of necrosis (p = 0.74, 0.33). CONCLUSIONS: Resveratrol decreased cellular survival of cultured HTFBs and induced apoptosis. Thus, resveratrol may exert antiproliferative effects on HTFBs.
Apoptosis
;
Fibroblasts*
;
Flow Cytometry
;
Humans*
;
Necrosis
;
Tenon Capsule
8.Comparison of Synthetic Surfactant with Modified Bovine Surfactant in Neonatal Respiratory Distress Syndrome.
Eun Kyung LEE ; Yong See JUN ; Won Soon PARK
Journal of the Korean Society of Neonatology 1999;6(2):154-161
PROPOSE: This study was designed to compare the efficacy of a synthetic surfactant (Exosurf) and a modified bovine surfactant (SurfactenR) in the treatment of neonatal respiratory distress syndrome. METHODS: A total of 90 infants with respiratory distress syndrome who were admitted to neonatal intensive care unit at Samsung Medical Center between October 1994 to September 1996 were includeeach surfactant. RESULTS: There was no significant difference in between two groups regarding birth weight, gestational age, and initiation of treatment after birth. ExosurfR group received less supplemental oxygen therapy and ventilator care. Survival rate were 81.3R in Exosurf group and 79.2% in SurfactenR group. The incidences of patent ctus arteriosus in the ExosurfR and SurfactenR groups were 75% and 62.5%, grade 3-4 intcular hemorrhage were 18.8% and 10.4%, respectively,' retinopathy of prematurity were 9.4% and 18.8%, respectively. There was significant improvernent of a/APO2 and VI at 30 minutes and 2 hours after the treatment in SurfactenR group', 2 hours and 6 hours after the treatment in ExosurfR group, however, dynamic compliance and respiratory resistance did not improve during 24 hours. CONCLUSION: Although SurfactenR treatment appears to induce faster improvement in oxygenation and pulmonary function than ExosurfR treatment, this study does not reveal any difference in clinical outcomes among those who received two different surfactant preparations.
Birth Weight
;
Compliance
;
Gestational Age
;
Hemorrhage
;
Humans
;
Incidence
;
Infant
;
Infant, Newborn
;
Intensive Care, Neonatal
;
Oxygen
;
Parturition
;
Respiratory Distress Syndrome, Newborn*
;
Retinopathy of Prematurity
;
Survival Rate
;
Ventilators, Mechanical
9.Effects of Valproic Acid on the Survival of Human Tennon's Capsule Fibroblasts
Journal of the Korean Ophthalmological Society 2018;59(11):1056-1061
PURPOSE: To investigate the effects of valproic acid on the survival of cultured human Tenon's capsule fibroblasts (HTFBs). METHODS: Primary cultured HTFBs were exposed to 0, 0.25, 0.5, and 1.0 mM valproic acid with or without 0, 1.0, 2.5 µg/mL mitomycin C, and incubated for 5 days. Cell survival was assessed using an MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and the degree of apoptosis was assessed by flow cytometry using annexin-V/propidium iodide double staining. RESULTS: Valproic acid decreased the survival of HTFBs in a dose-dependent manner, and survival was further decreased by adding mitomycin C to valproic acid. Both valproic acid and mitomycin C induced apoptosis of HTFBs. Valproic acid induced less apoptosis than mitomycin C. CONCLUSIONS: Valproic acid decreased the cellular survival of HTFBs and induced apoptosis. The antiproliferative effects of valproic acid were further enhanced by the addition of mitomycin C.
Apoptosis
;
Cell Survival
;
Fibroblasts
;
Flow Cytometry
;
Humans
;
Mitomycin
;
Tenon Capsule
;
Valproic Acid
10.Diffusion-Weighted Imaging of Brain Injury Due to Neonatal Hypoglycemia: A Case Report.
Eun A HEO ; See Sung CHOI ; Se Jeong JEON ; Eun A KIM ; Young Hwan LEE ; Seon Kwan JUHNG
Journal of the Korean Radiological Society 2006;55(4):407-410
Profound hypoglycemia results in significant brain injury because glucose is essential for normal brain functioning. We present here a case of transient neonatal hypoglycemia with diffuse brain injury. Magnetic resonance imaging was performed 2 days after onset, and this revealed bilateral regions of restricted diffusion in the parietal, occipital, frontal and temporal lobes. On the T1-weighted images, the regions showed indistinct gray matter-white matter differentiation. There were subtle high signal intensity lesions along the corresponding regions of the FLAIR and T2-weighted images.
Brain Injuries*
;
Brain*
;
Diffusion
;
Glucose
;
Hypoglycemia*
;
Magnetic Resonance Imaging
;
Rabeprazole
;
Temporal Lobe