No abstract available.
Humans* ; Sebum*

Omphalith generally consists of keratinous materials and sebum. It gradually forms a stone-like hard, dark brown to a black mass in elderly persons with deep umbilical depression and not clean umbilicus. A 75 years old male noticed a brownish black nodule on the umbilical depression 2 weeks ago. He did not try to remove it. This nodule gradually became to project from umbilical depression accompanied with intermittent pain. Removed specimen was brownish black stonelike on projecting polypoid lesion, but in umbilical depression, yellowish brown and not so hard. Histopathological examination showed a small quantity of melanin granules, but no nuclear components of cells.
Aged ; Depression ; Humans ; Male ; Melanins ; Sebum ; Umbilicus

BACKGROUND: An increasing number of methods have been developed to determine skin properties in an objective way. Variable atmospheric conditions or climatic changes influence the physiological reaction process occurring in skin. Clinical studies investigating skin conditions are often performed through different seasonal environments. Therefore, physiological stabilization course in a standard environment is necessary to exclude climatic influence before measuring skin physiological parameters. OBJECTIVE: The purpose of this study was to investigate stabilization course of several skin physiological parameters after exposure to summer and winter conditions. METHODS: Fifteen healthy volunteers (9 males, 6 females) with normal skin, of age 20 to 35 (mean 25.3) years were included in the study. After 30 minutes exposure to summer or winter climatic conditions, the volunteers stayed in the standard environment for 30 minutes. Skin surface temperature, skin color, transepidermal water loss (TEWL) and sebum were measured every 10 minutes in the standard room. RESULTS: Skin surface temperature stabilized after 20 minutes on forehead and 30 minutes on cheek irrespective of the season. Skin color (L*, a*, b*) stabilized after 20 minutes in standard environment irrespective of the season and location of measurement. TEWL stabilized after 10 minutes and sebum stabilized after 20 minutes in standard environment irrespective of the season and location of measurement. CONCLUSION: To obtain stabilized values of skin surface temperature, skin color, TEWL and sebum irrespective of season and measurement location, 30 minutes of stabilization course is needed.
Cheek ; Forehead ; Humans ; Male ; Seasons ; Sebum ; Skin ; Skin Temperature

BACKGROUND: In the last few decades, there has been a substantial increase in the population of aged people. Aging skin is a common concern for many people these days. OBJECTIVE: The purpose of this study was to evaluate the efficacy of cosmetics containing Ascidian tunic in reducing wrinkles. METHODS: Cream containing the Ascidian tunic was applied to right lateral epicanthal areas of 30 subjects for 8 weeks. As control group, a placebo which does not contain the Ascidian tunic was applied to the left lateral epicanthal areas of the subjects. Skin barrier function was evaluated and skin replicas were molded on both epicanthal areas every 4 weeks. The changes of the skin wrinkles were analyzed with skin visiometer. RESULTS: In comparison of the changes between groups treated with placebo and Ascidian tunic, there was statistically significant differences in hydration and sebum secretion. But there were no statistically significant differences in the result of R-value by visiometer. CONCLUSION: The treatment of Ascidian tunic extract seems to be partially effective in improving wrinkles, but further study is required.
Aged ; Aging ; Cosmetics ; Fungi ; Humans ; Sebum ; Skin ; Urochordata

BACKGROUND: Glycolic acid and Jessner's solution have been popular agents for superficial chemical peeling to treat facial acne. Increased sebum secretion is one of the major etiological factors of acne. There has been no report to compare effects on sebum secretion in patients with facial acne between glycolic acid peeling and Jessner's solution peeling. OBJECTIVE: We compared the effects on sebum secretion in patients with facial acne after glycolic acid peeling or Jessner's solution peeling. METHODS: Twenty patients with facial acne vulgaris were studied. Eight patients were treated with 30% glycolic acid peeling and twelve patients with Jessner's solution peeling. Before and 2 weeks after the treatment, the sebum levels of forehead, nose, center of chin and both cheeks were measured by using Sebumeter(R). RESULTS: The sebum levels were not significantly changed after 30% glycolic acid peeling. After Jessner's solution peeling, the total average, and average of T-zone of sebum levels, were reduced significantly (p<0.05). The high-sebum-level area was defined as the area where the sebum level before treatment was high. The average of sebum levels of the high-sebum-level area was reduced significantly (p<0.01). CONCLUSION: 30% glycolic acid peeling did not affect sebum secretion, but Jessner's solution peeling reduced sebum secretion in patients with facial acne significantly, especially on the areas where sebum secretion was high.
Acne Vulgaris* ; Cheek ; Chin ; Forehead ; Humans ; Nose ; Sebum*

Acne vulgaris is an inflammatory disease of hair follicle sebaceous gland units,with an incidence of up to 85% in adolescents.The pathogenesis is closely related to androgen,sebum secretion,lipophilic microbial infection,and immune-inflammatory reaction.This article reviews the signaling pathways related to acne from the aspects of inflammatory signaling pathways and sebum secretion pathways.
Acne Vulgaris ; Adolescent ; Humans ; Sebaceous Glands ; Sebum ; Signal Transduction

BACKGROUND: Although sebum secretion is crucial for acne development, acne lesion distribution is not always similar to the topographic differences of sebum secretion. OBJECTIVE: To analyze whether sebum secretion affects acne development and distribution and to assess other factors possibly influencing the relationship between acne and sebum secretion. METHODS: This single-center retrospective study included 67 acne patients and 50 controls. Acne patients were divided into 3 groups based on acne lesion distribution: T-zone dominant, U-zone dominant, and mixed groups. The secreted sebum level in each zone of acne patients was compared with that of controls. We also conducted correlation analysis between secreted sebum level and acne number, depending on the facial zone. RESULTS: No significant difference was found between acne patients and controls regarding age and sex ratio. The U-zone dominant group showed increased sebum levels compared with controls in the U-zone and whole face, but a similar result was not obtained in the T-zone dominant group. Moreover, there was a significant correlation between the number of lesions and secreted sebum level in the U-zone, but not in the T-zone. Further, there was a more significant relation in the U-zone of male and young patients. CONCLUSION: We found that increased sebum secretion compared with the condition may affect acne development, especially in the U-zone. Sex and age may also influence the relationship between acne and increased sebum secretion. Acne lesion distribution may vary from patient to patient because sebum secretion affects acne differently depending on multiple factors.
Acne Vulgaris ; Humans ; Male ; Retrospective Studies ; Sebum ; Sex Ratio

The authors describe a case of large dermoid cyst of the scalp which removed surgically and cosmetically. Dermoid cyst is derived from epiblastic cells predestined to form skin which become detached from their neighbours and included in mesenchyme at about third to the fifth week of feral life, when the neural tube is closing. The contents of the cyst are thus mixtures of keratin, sebum, and hair, according to the proportionate development of these elements. It is usually a single tumor and may develop almost anywhere in the subcutaneous tissue, being of variable size.
Dermoid Cyst* ; Germ Layers ; Hair ; Mesoderm ; Neural Tube ; Scalp ; Sebum ; Skin ; Subcutaneous Tissue

BACKGROUND: The clinical symptoms of facial and truncal acne differ. Skin surface acidity (pH), which is affected by sebum secretions, reflects the different clinical characteristics of the face and trunk. However, no studies have been conducted on truncal sebum production and skin pH. OBJECTIVE: We evaluated the differences and relationship between pH values of the face and trunk. We also evaluated the relationship between pH and the quantity of sebum produced in the trunk. METHODS: A total of 35 female patients clinically diagnosed with truncal acne were included. We measured pH on the face and truncal area using the Skin-pH-Meter PH 905®. We measured truncal sebum secretions using the Sebumeter SM 815®. Statistical analysis was performed to evaluate the correlations and differences between pH and sebum. RESULTS: Facial pH was significantly higher than chest and back pH values. The correlation between pH on the trunk and the face was significant. We used linear regression equations to estimate truncal pH using only measured pH from the chin. There was no significant relationship between truncal sebum secretion and pH. CONCLUSION: This was the first study that evaluated the differences and correlations between facial and truncal pH. We found that facial pH can predict truncal pH. In addition, we conclude that differences in pH and sebum secretion between the face and trunk are one of the reasons for differences in acne symptom at those sites.
Acne Vulgaris ; Chin ; Female ; Humans ; Hydrogen-Ion Concentration* ; Linear Models ; Sebum ; Skin ; Thorax

BACKGROUND: The clinical symptoms of facial and truncal acne differ. Skin surface acidity (pH), which is affected by sebum secretions, reflects the different clinical characteristics of the face and trunk. However, no studies have been conducted on truncal sebum production and skin pH. OBJECTIVE: We evaluated the differences and relationship between pH values of the face and trunk. We also evaluated the relationship between pH and the quantity of sebum produced in the trunk. METHODS: A total of 35 female patients clinically diagnosed with truncal acne were included. We measured pH on the face and truncal area using the Skin-pH-Meter PH 905®. We measured truncal sebum secretions using the Sebumeter SM 815®. Statistical analysis was performed to evaluate the correlations and differences between pH and sebum. RESULTS: Facial pH was significantly higher than chest and back pH values. The correlation between pH on the trunk and the face was significant. We used linear regression equations to estimate truncal pH using only measured pH from the chin. There was no significant relationship between truncal sebum secretion and pH. CONCLUSION: This was the first study that evaluated the differences and correlations between facial and truncal pH. We found that facial pH can predict truncal pH. In addition, we conclude that differences in pH and sebum secretion between the face and trunk are one of the reasons for differences in acne symptom at those sites.
Acne Vulgaris ; Chin ; Female ; Humans ; Hydrogen-Ion Concentration* ; Linear Models ; Sebum ; Skin ; Thorax