1.Expression and significance of cytokeratins in skin adenexal tumor.
Xin-Gong LI ; Li WEN ; Jing FU ; Zhi-Xiu XU ; Shu-Mei LIU ; Hong GAO ; Xi-Yin SUN ; Xiao-Qiu ZHOU
Chinese Journal of Pathology 2005;34(11):742-743
Adenoma, Sweat Gland
;
metabolism
;
Diagnosis, Differential
;
Humans
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Keratin-14
;
metabolism
;
Keratin-17
;
metabolism
;
Keratin-18
;
metabolism
;
Keratin-7
;
metabolism
;
Keratins
;
metabolism
;
Papilloma
;
metabolism
;
Sebaceous Gland Neoplasms
;
metabolism
;
Skin Neoplasms
;
metabolism
;
Sweat Gland Neoplasms
;
metabolism
2.Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein.
Kyung Ja CHO ; Shin Kwang KHANG ; Jae Soo KOH ; Jin Haeng CHUNG ; Seung Sook LEE
Journal of Korean Medical Science 2000;15(5):545-550
Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.
Adult
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Aged
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Aged, 80 and over
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Carcinoma/pathology*
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Carcinoma/metabolism
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Carcinoma/chemistry
;
Eyelid Neoplasms/pathology*
;
Eyelid Neoplasms/metabolism
;
Eyelid Neoplasms/chemistry
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Female
;
Human
;
Immunohistochemistry
;
Male
;
Middle Age
;
Necrosis
;
Receptor, erbB-2/biosynthesis*
;
Receptor, erbB-2/analysis
;
Receptors, Estrogen/analysis
;
Receptors, Progesterone/analysis
;
Sebaceous Gland Neoplasms/pathology*
;
Sebaceous Gland Neoplasms/metabolism
;
Sebaceous Gland Neoplasms/chemistry