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BACKGROUND: Succinylcholine is metabolized by plasma cholinesterase (PChE). When it was pretreated by small doses of nondepolarizing muscle relaxants in order to minimize the side effects, there are evidences to be associated with alteration in the duration of action. This study is investigated whether the responses would be related to the enzymatic activities. METHODS: In 21 adult patients, ASA class I or II, PChE levels were measured by the modified Garry method after induction of anesthesia (control value) and at 3, 10, 20 and 30 min following administration of pancuronium 0.1 mg/kg, vecuronium 0.1 mg/kg and atracurium 0.5 mg/kg. Data were expressed as mean (SEM). RESULTS: The levels of PChE were significantly lower (p<0.05) than the control values at 3, 10, 20 and 30 min after given pancuronium as 4764 (270), 4777 (261), 4796 (306) and 4740 (332) IU/L respectively and after given vecuronium as 5004 (341), 5051 (329), 4969 (340) and 4960 (340) IU/L respectively whereas enzyme levels after given atracurium were not significant differences to compare the control values as 5153 (336), 5136 (320) 5124 (312) and 5151 (275) respectively. CONCLUSIONS: The results of present study show that both pancuronium and vecuronium may possibly inhibit PChE activity but this was not affected by atracurium.
Adult ; Anesthesia ; Atracurium* ; Cholinesterases* ; Humans ; Pancuronium* ; Plasma* ; Succinylcholine ; Vecuronium Bromide*

9.Multiple combine therapy of primary varicose vein in lower extremities.

Doo Han SHIN ; Youn Soo KIM ; In Pyo HONG ; Jong Hwan KIM ; Se Il LEE ; Nam Ho KIM ; Young Ki SHIM

Journal of the Korean Society of Aesthetic Plastic Surgery 2000;6(2):154-161

10.Essential thrombocythemia.

Soo Gyeong KIM ; Se Jun HONG ; Hyun Soo KIM ; Woo Ik JANG ; Young Hak SHIM ; Myeongseo KANG

Korean Journal of Hematology 1992;27(1):141-147

1.Correction of mild lower eyelid ectropion by FTSG from neighboring skin.

2.A clinical study on semipermeability of tissue expanders.

3.The effect of chemical leech on the survival of aterialized island flaps of rabbit ear.

4.Clinical studies on the sensory recovery of finger tips covered by distant flaps.

5.A seropidemiological study on toxoplasma natibody in the cleft lip and cleft palate cases.

6.Rupture of silicone gel prosthesis after augmentation mammoplasty.

7.A case of pseudoxanthoma elasticum: case report.

8.Effect of Pancuronium, Vecuronium and Atracurium to the Plasma Cholinesterase Activity.

9.Multiple combine therapy of primary varicose vein in lower extremities.

10.Essential thrombocythemia.

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