2.Pathologic study of mice infected with Rickettsia tsutsugamushi R19 strain.
Tae Sook HWANG ; Young Chae CHU ; Young Bae KIM ; Byung Uk LIM ; Jae Seung KANG
Journal of Korean Medical Science 1993;8(6):437-445
Scrub typhus, an acute febrile infectious disease caused by R. tsutsugamushi, has been reported from various parts of the far east and pacific rim of Asia including Korea. It is well known that all human pathogenic rickettsia share an affinity to endothelial cells of the small blood vessels and evoke vascular inflammation variably associated with a rash, microthrombi, and hemorrhage. We infected the ICR mice by inoculating sublethal doses of R. tsutsugamushi R19 strain intraperitoneally and observed the pathologic changes by time sequence. The histopathologic features of experimentally induced scrub typhus in the mice were generally nonspecific interstitial inflammations characterized by interstitial pneumonitis, periportal inflammation, multifocal hepatic necrosis, interstitial nephritis, sinusoidal engorgement, and lymphohistiocytic cell infiltration in lymph nodes and spleen. Contrary to the general features of other rickettsial diseases, the pathologic process of scrub typhus experimentally induced by R. tsutsugamushi R19 strain mainly involved the interstitial connective tissue but not the blood vessels.
Animals
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Liver/pathology
;
Lung/pathology
;
Male
;
Mice
;
Mice, Inbred ICR
;
Scrub Typhus/*pathology
;
Spleen/pathology
3.Clinical analysis of liver injuries in Tsutsugamushi disease in old patients.
Ai-Guo YAN ; Zhao-Tang WANG ; Long-Cui ZHAO ; Li-Li HAN
Chinese Journal of Hepatology 2005;13(1):67-68
Age Factors
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Aged
;
Female
;
Humans
;
Liver
;
pathology
;
Male
;
Middle Aged
;
Scrub Typhus
;
diagnosis
;
pathology
4.Acute respiratory distress syndrome associated with scrub typhus: diffuse alveolar damage without pulmonary vasculitis.
Jae Seuk PARK ; Young Koo JEE ; Kye Young LEE ; Keun Yeol KIM ; Na Hye MYONG ; Pil Weon SEO
Journal of Korean Medical Science 2000;15(3):343-345
Pathologic findings of scrub typhus have been characterized by vasculitis of the microvasculature of the involved organ resulting from a direct invasion by Orientia tsutsugamushi. We experienced a case of acute respiratory distress syndrome (ARDS) associated with scrub typhus. The case was proven by eschar and high titer of serum IgM antibody (positive at 1:1280). Open lung biopsy showed diffuse alveolar damage (DAD) in the organizing stage without evidence of vasculitis. Immunofluorescent antibody staining and polymerase chain reaction for O. tsutsugamushi failed to demonstrate the organism in the lung tissue. The patient expired due to progressive respiratory failure despite doxycycline therapy. Immunologic mechanism, without direct invasion of the organism, may participate in the pathogenesis of ARDS associated with scrub typhus.
Acute Disease
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Aged
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Case Report
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Fatal Outcome
;
Female
;
Human
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Infant, Newborn
;
Pulmonary Alveoli/pathology
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Pulmonary Alveoli/injuries
;
Respiratory Distress Syndrome/physiopathology
;
Respiratory Distress Syndrome/pathology
;
Respiratory Distress Syndrome/immunology
;
Respiratory Distress Syndrome/complications*
;
Scrub Typhus/physiopathology
;
Scrub Typhus/pathology
;
Scrub Typhus/immunology
;
Scrub Typhus/complications*
;
Vasculitis
5.Two Cases of Scrub Typhus Presenting with Guillain-Barre Syndrome with Respiratory Failure.
Il Nam JU ; Jung Woo LEE ; Sung Yeoun CHO ; Seung Jee RYU ; Youn Jeong KIM ; Sang Il KIM ; Moon Won KANG
The Korean Journal of Internal Medicine 2011;26(4):474-476
No abstract available.
Diagnosis, Differential
;
Doxycycline/therapeutic use
;
Female
;
Guillain-Barre Syndrome/*diagnosis/pathology
;
Humans
;
Immunoglobulins/therapeutic use
;
Male
;
Middle Aged
;
Respiration, Artificial
;
Respiratory Insufficiency/*diagnosis/pathology
;
Scrub Typhus/*diagnosis/pathology