1.A case of Tsutsugamushi disease presenting with nephrotic syndrome.
Ju Hyun LEE ; Mi Jung LEE ; Dong Ho SHIN ; Shin Wook KANG ; Kyu Hun CHOI ; Tae Hyun YOO
The Korean Journal of Internal Medicine 2013;28(6):728-731
Nephrotic syndrome associated with Tsutsugamushi disease has not been previously reported. We are describing a case of Tsutsugamuchi disease presenting with nephrotic syndrome. A 72-year-old woman presented with fever and generalized edema. Laboratory studies revealed a leukocytosis, hypoalbuminemia, and hypercholesterolemia. Her urine protein excretion was 5.4 g/day. The anti-Tsutsugamushi antibody test was strongly positive (1:2,560). A renal biopsy was performed, and pathologic findings revealed membranous glomerulonephritis. The patient's clinical symptoms improved markedly after treatment with doxycycline.
Aged
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Anti-Bacterial Agents/therapeutic use
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Antibodies, Bacterial/blood
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Biopsy
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Doxycycline/therapeutic use
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Female
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Glomerulonephritis, Membranous/diagnosis/*etiology
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Humans
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Nephrotic Syndrome/diagnosis/*etiology
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Orientia tsutsugamushi/immunology
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Scrub Typhus/*complications/diagnosis/drug therapy/microbiology
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Treatment Outcome