No abstract available.
Scleromyxedema* ; Tacrolimus*

We describe two cases of acral persistent papular mucinosis. The characteristic findings include discrete papules on the extensor surfaces of the hands and wrists, mucous deposits within the dermis, persistence or slow progression for several years. APPM may be considered as the disease entity in the same spectrum with lichen myxedematosus.
Dermis ; Hand ; Scleromyxedema* ; Wrist

Acral persistent papular mucinosis is a subtype of the localized papular mucinosis. Clinically, ivory to flesh-colored papules develop exclusively on the back of the hands, the extensor surface of the wrists, and occasionally the distal forearms. Histologically, mucin accumulates in the upper reticular dermis, typically sparing a subepidermal zone and fibroblasts are not increased in number. On experiencing a case of numerous papules on both hands and forearms of a fifty year-old woman, we present it as acral persistent papular mucinosis.
Dermis ; Female ; Fibroblasts ; Forearm ; Hand ; Humans ; Mucins ; Scleromyxedema* ; Wrist

Papular mucinosis, also known as lichen myxedematosus or scleromyxedema, is a chronic cutaneous disorder characterizecl by infiltration of mucin in the dermis without abnormalities of thyroid function. It often combines serum monoclonal paraproteins. Various drugs have been used for the treatment without consistent results. We report a case of papular mucinosis in a 51-year-old man, who started the disease on his scalp 10 years before the first examination. Subsequent development of the characteristic glistening papular lesions on his entire scalp, eye brows, ears and upper back continued for 5 years thereafter until complete resolution. Treatment with corticosteroids and melphalan showed only limited effects during the period.
Adrenal Cortex Hormones ; Dermis ; Ear ; Humans ; Melphalan ; Middle Aged ; Mucins ; Paraproteins ; Scalp ; Scleromyxedema* ; Thyroid Gland

Scleromyxedema is a rare disorder characterized by generalized papular and sclerodermoid eruption, increased fibroblast proliferation, mucin deposition, and monoclonal gammopathy in the absence of thyroid disease. It is a generalized subtype of lichen myxedematosus. A paraproteinemia, typically an IgG lambda, is observed in more than 80% of patients with scleromyxedema. Here, we report a 38-year-old woman with a 1-year history of a progressively spreading of eruption of small papules on the entire body, including the face, neck, arms, legs, and trunk. Laboratory tests were within normal limits, except lambda light chain monoclonal gammopathy. We administered oral retinoid and topical steroid with slight clinical improvement. To our knowledge, this is the first reported case of scleromyxedema in Korea.
Adult ; Arm ; Female ; Fibroblasts ; Humans ; Immunoglobulin G ; Korea ; Leg ; Light ; Mucins ; Neck ; Paraproteinemias ; Scleromyxedema ; Thyroid Diseases

Papular mucinosis (PM, scleromyxoedema) is a rare dermatologic disease. It is histologically characterized by a focal dermal deposit of mucin within the skin. Although PM is accepted as an idiopathic disease in most cases, some authors argued that it may be a cutaneous manifestation of a systemic disease. Here, we describe a 68-year-old male kidney transplantation recipient with a complaint of intractable itching sensation on the forehead. We diagnosed the skin lesions as PM, which were improved after cyclosporine dose reduction.
Aged ; Cyclosporine ; Forehead ; Humans ; Kidney Transplantation* ; Male ; Mucins ; Pruritus ; Scleromyxedema* ; Sensation ; Skin

Lichen myxedematosus(LM), also known as papular mucinosis, is a rare, idiopathic disorder caused by the focal dermal deposition of mucin and occurs both as an isolated entity and manifestations of various systemic disorders. Cutaneous disease is common in patients infected with human immunodeficiency virus(HIV) and cutaneous mucinosis has been reported with increased frequency in HIV patients. A male patient with HIV infection was consulted to our clinic for evaluation of asymptomatic diffusely-scattered papules on his upper extremities and trunk. Histopathological finding was the deposition of mucin in the dermis and lichen myxedematosus type 2 was diagnosed. We present of a case of lichen myxedematosus in a HIV-infected male patient.
Dermis ; HIV Infections* ; HIV* ; Humans ; Lichens* ; Male ; Mucinoses ; Mucins ; Scleromyxedema* ; Upper Extremity

We report a case of acral persistent papular mucinosis in a 5 year-old female with multiple papules on both dorsa of the hands, wrists and forearms. Examination of a biopsy specimen showed a domeshaped lesion in the dermis composed of spindle-shaped fibrobla,sts and widely spaced collagen fibers. These spaces were filled with mucinous material, as demonstrated by positive staining with aleian blue at pH 2.5 and pH 0.5.
Biopsy ; Child, Preschool ; Collagen ; Dermis ; Female ; Forearm ; Hand ; Humans ; Hydrogen-Ion Concentration ; Mucinoses* ; Mucins ; Scleromyxedema ; Wrist

Acral persistent papular mucinosis has been thought to be a distinct for of cutaneous mucinosis not associated with systemic diseases. It was recently classified as one of five subtypes of localized lichen mixedematosus. A 64-year-old man presented with a 15-year history of flesh-colored to translucent papules and a few round hypopigmented patches on his wrists, back of the hands, and distal forearms. Biopsy from the papular lesions revealed focal mucin accumulation in the upper reticular dermis. The clinical and histopathological features were consistent with acral persistent papular mucinosis.
Biopsy ; Dermis ; Forearm ; Hand ; Humans ; Lichens ; Middle Aged ; Mucinoses ; Mucins ; Scleromyxedema* ; Wrist

Papulonodular mucinosis (PNM) is a rare variant of lupus erythematosus (LE) eruptions, and PNM is characterized histologically by diffuse dermal mucin without any typical epidermal inflammatory changes. We herein describe a case of papular mucinosis that was characterized by several erythematous papules on the lower back of a 32-year-old man with systemic LE. It is interesting that he didn't display any other skin manifestations of LE such as malar rash, discoid rash and photosensitivity during the previous 2 years. He achieved remission of his PNM without recurrence after 5 months treatment with topical steroids, in addition to receiving systemic antimalarials and steroids.
Adult ; Antimalarials ; Exanthema ; Humans ; Lupus Erythematosus, Systemic ; Mucinoses ; Mucins ; Recurrence ; Scleromyxedema ; Skin Manifestations ; Steroids