1.Study of Morphea.
Korean Journal of Dermatology 1968;6(1):25-28
No abstract available.
Scleroderma, Localized*
2.A Rare Case of Bilateral Frontal Linear Scleroderma (En Coup de Sabre)
Joo Ran HONG ; Ji Su LEE ; Yang Won LEE ; Yong Beom CHOE ; Kyu Joong AHN
Korean Journal of Dermatology 2019;57(6):346-347
No abstract available.
Scleroderma, Localized
3.Transient Bizarre Nystagmus With Frontal Linear Scleroderma With Brain Calcification.
Bek San PARK ; Hyuk Sung KWON ; Jinse PARK ; Hojin CHOI ; Kyu Yong LEE ; Young Joo LEE ; Seong Ho KOH
Journal of the Korean Neurological Association 2012;30(3):241-243
No abstract available.
Brain
;
Scleroderma, Localized
;
Scleroderma, Systemic
4.A Case of Segmental Vitiligo with Generalized Morphea Stabilized by Antimalarial Medication.
Hee Jung KIM ; Dongyun SHIN ; Sang Ho OH
Annals of Dermatology 2016;28(2):249-250
No abstract available.
Scleroderma, Localized*
;
Vitiligo*
5.A Case of Segmental Vitiligo with Generalized Morphea Stabilized by Antimalarial Medication.
Hee Jung KIM ; Dongyun SHIN ; Sang Ho OH
Annals of Dermatology 2016;28(2):249-250
No abstract available.
Scleroderma, Localized*
;
Vitiligo*
6.Linear Scleroderma Clinically Improved with Cyclosporine.
Su Jin OH ; Hyung Kwon PARK ; Young Gyun KIM ; Joung Soo KIM ; Hee Joon YU
Korean Journal of Dermatology 2016;54(6):487-489
No abstract available.
Cyclosporine*
;
Scleroderma, Localized*
7.Linear Scleroderma Clinically Improved with Cyclosporine.
Su Jin OH ; Hyung Kwon PARK ; Young Gyun KIM ; Joung Soo KIM ; Hee Joon YU
Korean Journal of Dermatology 2016;54(6):487-489
No abstract available.
Cyclosporine*
;
Scleroderma, Localized*
8.A Case of a Bitemporal Atrophic Scar induced by Morphea, and treated by Autologous Fat Transplantation.
Hyung Su KIM ; Young Joon CHO ; Sang Eun MOON
Korean Journal of Dermatology 2005;43(9):1257-1259
A contour change induced by a subcutaneous depleting disorder such as lupus or morphea can be corrected by filling the defect with an artificial or natural materials of the types of fillers, autologous fat is popularly utilized for volumetric correction. Autologus fat has many advantages, such as easy harvesting, free volume, and non-immunogenicity. Herein, we report a case who of a bilateral atrophic scar on the temple area induced by morphea which was successfully treated by autologous fat transplantation.
Cicatrix*
;
Scleroderma, Localized*
9.Treatment of morphea with narrowband ultraviolet B: A case series
Ma. Lorna F. Frez ; Kathleen May V. Eusebio-Alpapara ; Georgina C. Pastorfide ; Rochelle L. Castillo ; Giselle S. Tioleco-Ver
Journal of the Philippine Dermatological Society 2019;28(2):35-49
Introduction:
Morphea, is a rare autoimmune disease presenting with fibrotic changes in the dermis and subcutis. It
is a benign condition associated with significant atrophy and sclerosis leading to disfigurement, flexure contractures,
and impaired function. Ultraviolet A1 and photochemotherapy are highly effective treatment options but are not
readily available in the country. Narrowband ultraviolet B (NBUVB), on the other hand, is readily available, affordable,
and safe to use.
Case summary:
Three patients diagnosed with different variants of morphea (bilateral generalize morphea, unilateral
generalized morphea, and circumscribed morphea). underwent 30 sessions of NBUVB. Treatment response was
assessed using tightness and itch Visual Analogue Scale (VAS), Modified Skin Score (MSS), photographic comparison,
ultrasonographic measurement, and histopathologic analysis.
NBUVB treatment resulted to 14-60% decrease in the tightness and itch VAS. MSS was also reduced by 35-50%. The
size, pigmentation, and erythema of the lesions also decreased. Ultrasonography showed an improvement in the
thickness of lesions after treatment. Histopathologic study showed less packed collagen with increase in inter-bundle
spaces.
Conclusion
Response to treatment was influenced by the age of the lesion and anatomical location. More chronic
lesions tend to have less response. Lesions on the face exhibited the greatest improvement while lesions on the
lower extremities had the least improvement. This is the first case series study in the country that uses NBUVB
as treatment for morphea. The improvement of the sclerotic and atrophic lesions treated with narrowband UVB
treatment may be an acceptable substitute for UVA1 and PUVA.
Scleroderma, Localized
;
Phototherapy
10.Guttate Morphea in a 31-year-old Filipino female: A diagnostic challenge in its early stage
Nadine Elizabeth V. Romano ; Ruth B. Medel ; Cindy Jao Tan ; Camille B. Angeles
Journal of the Philippine Medical Association 2024;102(2):89-94
Introduction:
Morpheq, also known as localized
scleroderma, describes a distinctive inflammatory
skin disorder that ultimately leads to sclerosis. It is
differentiated from systemic scleroderma by the
absence of vasculopathy and organ involvement.
Initial erythema may precede the sclerotic stage by
a few months causing initial diagnostic confusion.
High index of suspicion and knowledge of disease
evolution are essential. We report a case of
morphea and its progression, the diagnostic
approach and the importance of early treatment
and long-term monitoring.
Case Summary:
A 3l-year-old Filipino female who
presented with multiple erythematous plagues on
the trunk and extremities and arthralgia was
initially diagnosed with cutaneous drug reaction.
Prompt treatment led to partial relief of symptoms.
However, two months later, eruption of multiple
ivory-white small patches and plaques were
noted on the same affected areas prompting an
impression of morphea. Serum markers revealed
elevated antinuclear antibody levels and negative
anti-Scl70/anti-centromere serum autoantibodies.
Skin biopsy showed homogenized thick dermal
collagen bundles confirming the diagnosis of
morphea. Topical therapy with calcipotriol
+ betamethasone dipropionate ointment showed remarkable improvement with decrease in
erythema and softening of the lesions while
adjunct narrowband-UVB phototherapy also
provided relief due to its ability to reduce collagen
synthesis and cytokine production.
Conclusion
Morphea may be easily misdiagnosed
during the early stages especially if sclerosis
ensues late in the disease. Characteristic clinical
appearance of erythematous plaques with
violaceous borders may not always be present.
Histologic examination and serum autoantibodies
help exclude other disorders with the same clinical
and histopathological spectrum. Treatment is
individualized depending on the severity and depth
of skin involvement, early treatment and
monitoring should be initiated before
complications arise.
Scleroderma, Localized
;
Fibrosis