The eyeball can be divided into the anterior and posterior compartment bordering on the lens. The ocular wallis composed of three layers, namely the sclera, choroid and retina. Different pathologic conditions can occur,depending on the anatomic location. This paper illustrates the anatomical features of normal eyeball, as seen onMRI, and a variety of pathologic conditions of the compartments. An understanding of the MR features of variousintraocular lesions is thus facilitated
Choroid ; Magnetic Resonance Imaging* ; Pathology* ; Retina ; Sclera

The purpose of this report is to investigate experimentally how the corea, sclera, crystalline lens and focusing lens influence the ultrasound intensity and beam width and to find characteristic differences due to the transducer parameters; frequency and size. A time-amplitude ultrasonic diagnostic apparatus, Aloka Model SSD-2D was used with transcucers of 10 MHz and 5 MHz, 10 mm and 5 mm diameters. The metal ball, 1 mm in diameter, was served as the echo-reflecting target which was immersed in water and moved horizontally under the transducer with a micrometer screw. The distances between the transducer and the metal ball varied from 10 mm to 50 mm in 10 mm step. The amplitudes curves of the echoes so obtained were represented by relative values. In water control experiment, the nearer the metal ball from the transducer, the more irregular the curves, with multiple amplitudes maxima and minima. These irregular curves became homogeneous as the transducer moved away from the target. The multiple peak curves were more marked when measured with transducers of higher frequency and larger diameter. At the end of the near field only a single peak was found in the axial portion of the sound field. In the far field, the beam width reduced slightly due to the divergence of the beam accompanied by slight attenuation of the echo amplitudes. When the sound beam passed through the cornea and sclera, the form of the curves remained almost unchanged, but the amplitudes decreased slightly due to the absorption of the sound energy. Scleral tissue absorbed the energy more strongly then the corneal tissue. When the crystalline lens was placed under the transducer, divergence of the beam and themoderate absorption took place. This effect was more pronounced with the use of transducers of higher frequency and smaller diameter. When a focusing lens, 25 mm focal length, was attached to the transducer surface, sound beam converged to a narrow zone, followed by later scattering. These results suggest that the transducer should be selected as to the frequency and diameter according to the site of the lesion suspected and the nature of the pathology.
Absorption ; Cornea ; Lens, Crystalline ; Pathology ; Sclera ; Transducers ; Ultrasonics* ; Ultrasonography ; Water

Eight consecutive case of the slipped muscle are recognized and treated with the surgical intervention. All patients showed a large-angle exotropia(30 - 70 prism diopter), moderative to severe degree of limitation of adduction(-1.5 - -3) and negative forced duction test. Intraoperatively, we could identify the empty muscle capsule attached to the sclera with the tendon slipped posteriorly within its capsule. Repair is accomplished by resecting the empty capsule and advancing the true tendon to or toward the original insertion. After the average follow up period of 36.1 weeks, the amount of reduced within 10 prism diopters and limitation of duction within-0.5 in all patients. A better understanding of the pathology may lead to early diagnosis and surgical repair, and then the prognosis for functional and cosmetic result will be excellent.
Early Diagnosis ; Follow-Up Studies ; Humans ; Pathology ; Prognosis ; Sclera ; Tendons

A two-year-old girl was admitted due to repeated yellowing of the skin and sclera for 2 years and had no other specific symptoms or signs. The use of phenobarbital could relieve the symptoms of jaundice. Multiple examinations showed increased indirect bilirubin levels, and the results of aminotransferases and liver imaging were normal. There was no evidence of hemolysis. The analysis of UGT1A1 gene in her family found that this child had double homozygous mutation of c.211G>A(G71R) and c.1456T>G(Y486D), which had been reported as the pathogenic mutation for Gilbert syndrome. Her parents carried double heterozygous mutation of G71R and Y486D and had no symptom of jaundice. The child was diagnosed as having Gilbert syndrome. It is concluded that as for patients with unconjugated hyperbilirubinemia which cannot be explained by liver damage and hemolysis, their family history should be investigated in detail and gene analysis should be performed as early as possible, in order to identify congenital bilirubin metabolic disorders.
Child, Preschool ; Female ; Gilbert Disease ; diagnosis ; Glucuronosyltransferase ; genetics ; Humans ; Mutation ; Sclera ; pathology ; Skin ; pathology

PURPOSE: To evaluate the change of axial length (AL), intraocular pressure (IOP), and corneal astigmatism after scleral shortening with scleral invagination in the rabbit eye. METHODS: The authors performed scleral shortening (3 mm) with scleral invagination in two groups of 6 eyes each: 180 degrees (group 1) and 360 degrees (group 2). RESULTS: Average AL shortening was more prominent in group 2 (0.5 +/- 0.17 mm) than in group 1 (0.37 +/- 0.29 mm), but the difference was not statistically significant. IOP increased immediately after the procedure and was maintained at a high level through 2 months postoperatively. Induced corneal astigmatism was more prominent in group 1 than in group 2. The difference was statistically significant in group 1 (p< 0.05) but not in group 2. CONCLUSIONS: In the scleral shortening with scleral invagination procedure, a large amount of scleral invagination resulted in more shortening of axial length, but there was more corneal astigmatism in 180-degree invagination of the sclera than in 360-degree. Further research is required to determine the effect of the extent of scleral invagination on the change of these values.
Animals ; Astigmatism/*etiology ; Corneal Diseases/*etiology ; Eye/*pathology ; *Intraocular Pressure ; Postoperative Period ; Rabbits ; Sclera/*surgery

1. Alkali burns of rabbit corneas were produced by 5.0 N NaOH swabbing the cornea and surrounding sclera. 2. Collagenolytic activity of alkali burned corneas, and the effectiveness of collagenase inhibitors (0.2 M cysteine sol. and 0.5% zinc sulfate sol.) in preventing the perforation of corneas were studied by pathology. 3. In control group, almost 85% of coreas were perforated, but in treated group, no corneal perforations were found. 4. In control group, epithelial and endothelial thickenings are evident and no neovascularization could be seen, in treated group neovascularization is evident and slight cellular reactions were visualized.
Alkalies* ; Burns* ; Cornea* ; Corneal Perforation ; Cysteine ; Matrix Metalloproteinase Inhibitors ; Pathology ; Sclera ; Zinc Sulfate

The purpose of this paper is to describe the most appropriate surgical techniques in the repair of retinal dialyses up to 180 degrees. In this sesies, silicon bands were used as an encircling element with conserved sclera implant. Perhaps a circling buckle will decrease a traction of vitreoretinal pathology located in equatorial area and reduce the rate of recurrence in patients who are exposed to an active life with repeated minor traumata. Retinal dialyses up to 90 degrees have been treated with a shorter and higher implant because the ends stretch the retina circumferentially by the sloping ends of the buckle. All of the 37 eyes with a dialysis up to 90 degrees and a clinical retinal detachment maintained successful reattachment of the retina. In retinal dialyses between 90-180 degrees a long, broad and lower implant was applied. The sclera was lamellarly dissected into two flaps extending approximately one hour of the clock beyond each end of the tear. In five of ten eyes with giant break, the posterior edge of tear could be settled on the underlying pigment epithelium during slight compression on sclera with Eisner's contact lens ane in five eyes the flap was everted and immobile. The retina was intentionally incarce rated on the buckle when the flap was everted and immobile. By this technique a giant dialysis could be transformed into two neighbouring dialyses up to 90 degrees. Of those eyes without everted three out of five were successfully reattached and of those eyes with an everted immobile flap four out of five eyes. 93.6% of the consecutive 47 cases of dialyses with a clinical retinal detachment were successfully reattached. If the patient with a postequatorial large horseshoe-shaped tear and a case with chorioretinohyalopathy and neovascularization of the chamber angle were excluded, the success rate rose to 97.9%. Three cases of the successful reattachment required a second operation. This report reviewed the results of the technique in the treatment of retinal detachment caused by dialyses up to 180 degrees. In a previous study, the management yielded a 95.7% success rate in retinal detachment caused by equatorial break operated by one of us. No comparison can be made between the success rate of these two types of tears (P>0.05) since all gave consistently excellent result.
Dialysis* ; Epithelium ; Humans ; Intention ; Pathology ; Recurrence ; Retina ; Retinal Detachment ; Retinal Perforations ; Retinaldehyde* ; Sclera ; Silicones ; Traction

Preoperative aqueous humor, known to inhibit the growth of fibroblasts in tissue culture assay, was used as an adjunct to filtering surgery in rabbits to determine its effect in vivo on the outcome of filtering surgery. Fifteen rabbits underwent a posterior-lip sclerectomy in both eyes. In experimental eyes 1.4 ml preoperative aqueous humor and in fellow eyes 1.4 ml balanced salt solution were injected intracamerally. Gross and histopathological differences of bleb were observed. In this animal experiment, although there was no statistical significance or late postoperative effect, the rabbit eyes refilled with preoperative aqueous humor intracamerally just after filtering surgery, had a larger bleb and less fibroconnective tissue on the bleb than the control eyes in the early postoperative period.
Animals ; Anterior Chamber/*pathology ; Aqueous Humor/*physiology ; Connective Tissue/pathology ; Fibroblasts/pathology ; Isotonic Solutions ; Rabbits ; Sclera/surgery

Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient.
Carcinoma/*pathology/therapy ; Choroid/*pathology ; Choroid Neoplasms/*secondary/therapy ; Humans ; Hyperthermia, Induced ; Lung Neoplasms/secondary ; Male ; Middle Aged ; Sclera/*pathology ; Thyroid Neoplasms/*pathology/therapy

In the process of closing scleral wounds caused by various conditions, incarceration of conjunctiva, Tenon's capsule, or vitreous in the wound can occur unexpectedly. We created such conditions experimentally in order to discover their intraocular complications. The experimental materials consisted of 12 albino rabbits (24 eyes) divided into two groups (Groups I & II). Vitrectomy was performed in the Group I rabbits (12 eyes) but not in the Group II rabbits (12 eyes). Flaps of conjunctiva and Tenon's capsule were made and inserted into the vitreous cavity through the sclerotomy site, which was soon closed. Fundal examination of the rabbits was carried out using an indirect ophthalmoscope at intervals after the procedure; first at 3 days, then at 1, 3, and 6 weeks, and then at 3 months and 6 months, respectively. Enucleation of the rabbits' eyes 4 from two different rabbits at each of these intervals was carried out, and the extracted eyes were examined under a light microscope at each interval. The results are summarized as follows: 1. All rabbit eyes studied showed intraocular fibrovascular proliferation. 2. The extent of tissue proliferation, which was proportional to the amount of vitreous hemorrhage, was greater in Group II than in Group I. 3. The proliferated tissue developed to "band" by three weeks postexperiment, after which it gradually regressed. 4. The fibrovascular band was made of fibroblasts, stromal matrix, and capillaries.
Animals ; Cell Division ; Conjunctiva/pathology ; Eye Injuries/surgery ; Fundus Oculi ; Postoperative Complications ; Rabbits ; Retinal Diseases/pathology ; Retinal Vessels/*pathology ; Sclera/*surgery ; Vitrectomy ; Vitreous Hemorrhage/pathology