1.Erratum: Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction.
Savas GUZEL ; Ozden SERIN ; Eda Celik GUZEL ; Banu BUYUK ; Guzin YILMAZ ; Guvenc GUVENEN
The Korean Journal of Internal Medicine 2013;28(3):386-386
In the article, there were two spelling errors in the title and author affiliation.
2.Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction.
Savas GUZEL ; Ozden SERIN ; Eda Celik GUZEL ; Banu BUYUK ; Guzin YILMAZ ; Guvenc GUVENEN
The Korean Journal of Internal Medicine 2013;28(2):165-173
BACKGROUND/AIMS: Acute coronary syndrome (ACS) is characterized by increased inflammatory processes and endothelial activation. We investigated the association between ACS and inflammatory mediators and matrix-degrading enzymes. METHODS: We prospectively enrolled 55 consecutive patients with ACS: 25 with unstable angina (UA) and 30 with non-ST elevated myocardial infarction (NSTEMI). For comparison, 25 age- and sex-matched subjects with no significant coronary artery stenosis were included as the control group. Peripheral serum levels of interleukin (IL)-33, matrix metalloproteinase (MMP)-9, tissue inhibitor of MMP-1, and C-reactive protein (CRP) were measured on admission, and at 12, 24, 48, and 72 hours after the initial evaluation. RESULTS: Compared to serum levels in the control group, serum levels of IL-33 decreased in the NSTEMI group (p < 0.05), and levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP)-1 increased in the UA group (p < 0.01, p < 0.05, respectively) and NSTEMI group (p < 0.05, p < 0.05, respectively). IL-33 levels were significantly lower on admission than at 12 hours after the initial evaluation (p < 0.05). IL-33 levels were negatively correlated with MMP-9 levels (r = -0.461, p < 0.05) and CRP levels (r = -0.441, p < 0.05). CONCLUSIONS: Elevated levels of MMP-9, TIMP-1, and decreased levels of IL-33 play a role in the development and progression of ACS.
Adult
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Angina, Unstable/blood/*enzymology/*immunology
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Biological Markers/blood
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C-Reactive Protein/metabolism
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Case-Control Studies
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Disease Progression
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Female
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Humans
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Inflammation Mediators/*blood
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Interleukins/*blood
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Male
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Matrix Metalloproteinase 9/*blood
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Middle Aged
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Myocardial Infarction/blood/*enzymology/*immunology
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Time Factors
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Tissue Inhibitor of Metalloproteinase-1/*blood