1.Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.
Bing WU ; Yue Bin LYU ; Zhao Jin CAO ; Yuan WEI ; Wan Ying SHI ; Xiang GAO ; Jin Hui ZHOU ; Virginia Byers KRAUS ; Feng ZHAO ; Xin CHEN ; Feng LU ; Ming Yuan ZHANG ; Ying Chun LIU ; Qi Yue TAN ; Shi Xun SONG ; Ying Li QU ; Xu Lin ZHENG ; Chong SHEN ; Chen MAO ; Xiao Ming SHI
Biomedical and Environmental Sciences 2021;34(11):859-870
Objective:
To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults.
Methods:
Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cognitive impairment was assessed by the Chinese Mini-Mental State Examination. Handgrip strength was calculated from the means of the right and left hand values. Calf circumference was measured at the site of maximum circumference of the non-dominant leg. The formula developed by Ishii was used to define sarcopenia. Multiple logistic regression was performed to evaluate the associations of sarcopenia, handgrip strength, and calf circumference with cognitive impairment.
Results:
The prevalence of cognitive impairment was 34.36%. The adjusted odds ratio (
Conclusion
Sarcopenia, identified by low handgrip strength and low calf circumference, was positively associated with cognitive impairment.
Aged
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Aged, 80 and over
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China/epidemiology*
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Cognitive Dysfunction/etiology*
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Female
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Hand Strength
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Humans
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Leg/anatomy & histology*
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Logistic Models
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Male
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Sarcopenia/pathology*
2.The Association between the Low Muscle Mass and Osteoporosis in Elderly Korean People.
Sunyoung KIM ; Chang Won WON ; Byung Sung KIM ; Hyun Rim CHOI ; Min Young MOON
Journal of Korean Medical Science 2014;29(7):995-1000
The purpose of this study was to predict osteoporosis risk as decreasing muscle mass and to declare the cut-off value of low muscle mass in an elderly Korean population. This study was based on data from the 2008-2010 Korea National Health and Nutritional Examination Surveys (KNHANES). The subjects included 1,308 men and 1,171 women over 65 yr. Bone mineral density (BMD) and appendicular skeletal muscle (ASM) were measured by dual energy X-ray absorptiometry (DXA), and appendicular skeletal muscle was adjusted by height as a marker of sarcopenia. After confirming the correlation between low muscle mass and BMD, the best cut-off value of muscle mass to estimate osteoporosis was suggested through the receiver operating characteristic (ROC) curve. For both men and women, BMD correlated positively with low muscle mass when ASM/Ht2 was used as a marker for sarcopenia. The ROC curve showed that ASM/Ht2 was the best marker for osteoporosis at a cut-off value of 6.85 kg/m2 for men and 5.96 kg/m2 for women. When these cut-off values were used to determine sarcopenia, the risk of osteoporosis increased 4.14 times in men and 1.88 times in women. In particular, men (OR 2.12) with sarcopenia were more greatly affected than women (OR 1.15), even after adjusting for osteoporosis risk factors. In elderly Korean people, sarcopenia is positively correlated with BMD and there is a strong correlation between sarcopenia and osteoporosis with risk of bone fracture.
Absorptiometry, Photon
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Aged
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Aged, 80 and over
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Area Under Curve
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Asian Continental Ancestry Group
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Body Mass Index
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Bone Density
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Female
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Humans
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Male
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Muscle, Skeletal/*pathology/radiography
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Nutrition Surveys
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Odds Ratio
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Osteoporosis/*diagnosis/etiology
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ROC Curve
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Republic of Korea
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Risk Factors
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Sarcopenia/physiopathology
3.Implication of Sarcopenia and Sarcopenic Obesity on Lung Function in Healthy Elderly: Using Korean National Health and Nutrition Examination Survey.
Ji Hyun MOON ; Mi Hee KONG ; Hyeon Ju KIM
Journal of Korean Medical Science 2015;30(11):1682-1688
Previous studies have demonstrated a positive association between obesity and decreased lung function. However, the effect of muscle and fat has not been fully assessed, especially in a healthy elderly population. In this study, we evaluated the impact of low muscle mass (LMM) and LMM with obesity on pulmonary impairment in healthy elderly subjects. Our study used data from the Korea National Health and Nutrition Examination Survey from 2008 to 2011. Men and women aged 65 yr or older were included. Muscle mass was measured by dual-energy X-ray absorptiometry. LMM was defined as two standard deviations below the sex-specific mean for young healthy adults. Obesity was defined as body mass index > or = 25 kg/m2. The prevalence of LMM in individuals aged over 65 was 11.9%. LMM and pulmonary function (forced vital capacity and forced expiratory volume in 1 second) were independently associated after adjusting for age, sex, body mass index, smoking status, alcohol consumption, and frequency of exercise. LMM with obesity was also related to a decrease in pulmonary function. This study revealed that LMM is an independent risk factor of decreased pulmonary function in healthy Korean men and women over 65 yr of age.
Age Distribution
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Aged
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Aged, 80 and over
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Causality
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Comorbidity
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Female
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Humans
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Lung Diseases/*epidemiology/*pathology
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Male
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Nutrition Surveys
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Obesity/*epidemiology/pathology
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Organ Size
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Prevalence
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Reference Values
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Reproducibility of Results
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Republic of Korea/epidemiology
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Respiratory Function Tests
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Respiratory Muscles/*pathology
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Risk Factors
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Sarcopenia/*epidemiology/*pathology
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Sensitivity and Specificity
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Sex Distribution