1.Pulmonary vein sarcoma: a case report.
Wei-min ZHANG ; Yong XU ; Zhi-nong JIANG ; Xue-feng SU ; Chao HE
Chinese Medical Journal 2012;125(5):954-956
Recently, we treated a patient with pulmonary vein sarcoma. The patient was a 41-year-old woman, had cough, short of breath and apsychia, with obvious jugular venous distention, rales in both lungs and a diastolic murmur at the apex. CT and Echo revealed a tumor in the left atrium. She received an emergency surgery to remove the mass in the heart. The pathological diagnosis demonstrated it as leiomyosarcoma. Though the patient accepted radiotherapy and chemotherapy, she still died of recurrence and metastasis of the sarcoma 10 months after operation.
Adult
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Fatal Outcome
;
Female
;
Humans
;
Pulmonary Veins
;
pathology
;
surgery
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Sarcoma
;
diagnosis
;
drug therapy
;
surgery
;
Vascular Neoplasms
;
diagnosis
;
drug therapy
;
surgery
2.Primary cutaneous histiocytic sarcoma.
Shu-hong ZHANG ; Xiao-ge ZHOU ; Peng WANG ; Yan-ning ZHANG ; Shou-fang HUANG
Chinese Journal of Pathology 2006;35(1):56-57
Aged
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Antineoplastic Agents
;
therapeutic use
;
B7-2 Antigen
;
analysis
;
Diagnosis, Differential
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Follow-Up Studies
;
Histiocytic Disorders, Malignant
;
drug therapy
;
metabolism
;
pathology
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Humans
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Male
;
Sarcoma
;
chemistry
;
drug therapy
;
pathology
;
Skin Neoplasms
;
chemistry
;
drug therapy
;
pathology
3.A Case of Undifferentiated (Embryonal) Liver Sarcoma Mimicking Klatskin Tumor in an Adult.
Ji Ae LEE ; Tae Wan KIM ; Jae Hoon MIN ; Sun Jung BYON ; Seung Hoon JANG ; Seung Yeon CHOI ; Hong Joo KIM
The Korean Journal of Gastroenterology 2010;55(2):144-148
Undifferentiated sarcoma is an uncommon primary malignant tumor of the liver typically occurring in older children. It is also referred to as malignant mesenchymoma, fibromyxosarcoma, or mesenchymal sarcoma. We experienced a case of undifferentiated sarcoma in 72-year-old male. Contrast enhanced liver CT scan revealed a 3.4 cm heterogeneously enhancing, ill-defined, and low attenuated mass in the left liver and subtle intrahepatic duct dilatation. And, in tubogram, there were segmental stenosis and occlusion from the hilum to the proximal common bile duct. We did ultrasonography guided liver biopsy. The pathologic finding revealed infiltrative growth of atypical cells with rhabdoid features. Some atypical cells showed clear cytoplasm, but no organoid pattern was identified. The stroma around atypical cells was filled with eosinophilic hyaline material. These tumor cells were positive for vimentin only, and the tumor was consistent with undifferentiated sarcoma of the liver.
Aged
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Bile Ducts, Intrahepatic/pathology
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Diagnosis, Differential
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Dilatation, Pathologic
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Humans
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Klatskin's Tumor/diagnosis
;
Liver Neoplasms/*diagnosis/pathology/ultrasonography
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Male
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Positron-Emission Tomography
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Sarcoma/*diagnosis/pathology/ultrasonography
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Tomography, X-Ray Computed
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Tuberculosis/drug therapy/radiography
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Vimentin/metabolism
4.A Case of the Treatment in an Adult with Hepatic Undifferentiated (Embryonal) Sarcoma.
Kyoung Tae KIM ; Sang Young HAN ; Eun Hee PARK ; Jin Seok JANG ; Myung Hwan ROH ; Sung Wook LEE ; Jin Sook JEONG
The Korean Journal of Hepatology 2007;13(1):96-102
Undifferentiated embryonal sarcoma is a rare primary malignant neoplasm of the liver. Undifferentiated sarcoma of the liver in adult is an uncommon hepatic tumor of mesenchymal origin, generally considered an aggressive neoplasm with an unfavorable prognosis. We present a case of undifferentiated sarcoma in a 61-year-old woman. CT scan demonstrated a large heterogenous, exophytic growing hepatic mass in the right lobe with pulmonary metastatic nodules. US guided liver biopsy was done and pathological findings of the liver specimen revealed that isolated or grouped round pleomorphic cells and spindle to stellate cells were present. Immunohistochemical stain showed that tumor cells expressed positivity for vimentin and partially positivity or negativity for cytokeratin. She was diagnosed as having undifferentiated sarcoma of the liver. She received seven courses of VAIA chemotherapy by CWS protocols. Chemotherapy was efficacious and the size of the tumor decreased considerably after the treatment. No tumor recurrence for 12 months is noted.
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
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Dactinomycin/therapeutic use
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Doxorubicin/therapeutic use
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Female
;
Humans
;
Ifosfamide/therapeutic use
;
Liver Neoplasms/*diagnosis/*drug therapy/pathology
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Middle Aged
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Sarcoma/*diagnosis/*drug therapy/pathology
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Tomography, X-Ray Computed
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Vincristine/therapeutic use
5.Extraskeletal Ewing's Sarcoma of the Head and Neck Presenting as Blindness.
Sung In CHO ; Yeon Hee PARK ; Jang Hyun CHO ; Baek Yeol RYOO ; Sung Hyun YANG ; Sang Min YOUN ; Jae Soo KO
The Korean Journal of Internal Medicine 2007;22(2):133-137
Extraskeletal Ewing's sarcoma is rarely found in the head and neck regions. We report an unusual case of extraskeletal Ewing's Sarcoma of the parapharynx region in a 49-year-old man who presented with blindness. MRI examination showed marked enhancement of tumor thrombosis involving the superior sagittal sinus, straight sinus, transverse sinus, sigmoid sinus, and internal jugular vein. The final diagnosis was extraskeletal Ewing's sarcoma after biopsy of the internal jugular vein thrombosis by histopathological evaluation and immunohistochemical assay. In addition, the patient was diagnosed as having adenocarcinoma of the rectum by biopsy of the rectal mass. The patient was treated with systemic chemotherapy and showed improved response with durable remission. The patient's visual acuity, however, did not improve.
Antineoplastic Agents/therapeutic use
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*Blindness
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Cyclophosphamide/therapeutic use
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Doxorubicin/therapeutic use
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Head and Neck Neoplasms/diagnosis/drug therapy/*pathology
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Humans
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Male
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Middle Aged
;
Sarcoma, Ewing's/diagnosis/drug therapy/*pathology
;
Vincristine/therapeutic use
6.Spindle cell variants of diffuse large B cell lymphoma: report of 2 cases.
Jun-chen WANG ; Da-ren SHI ; Xue-lian FU ; Chang-li LU ; Wan-ping LU
Chinese Journal of Pathology 2005;34(1):55-56
Antineoplastic Combined Chemotherapy Protocols
;
therapeutic use
;
Breast
;
pathology
;
Breast Neoplasms
;
drug therapy
;
pathology
;
Cyclophosphamide
;
therapeutic use
;
Diagnosis, Differential
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Doxorubicin
;
therapeutic use
;
Female
;
Follow-Up Studies
;
Humans
;
Lymphoma, B-Cell
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drug therapy
;
pathology
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Lymphoma, Large B-Cell, Diffuse
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drug therapy
;
pathology
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Male
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Middle Aged
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Prednisone
;
therapeutic use
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Sarcoma
;
pathology
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Spleen
;
pathology
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Splenic Neoplasms
;
drug therapy
;
pathology
;
Vincristine
;
therapeutic use
7.Clinicopathologic features of granulocytic sarcoma: a study of 38 cases.
Hai-yan LIU ; Hong-lin YIN ; Jun DU ; Ying CAI ; Zhen-feng LU ; Hang-bo ZHOU ; Xiao-jun ZHOU
Chinese Journal of Pathology 2010;39(3):172-176
OBJECTIVETo study the clinicopathologic features of granulocytic sarcoma.
METHODSThe clinical and pathologic findings of 38 cases of granulocytic sarcoma were retrospectively analyzed. Immunohistochemical study was performed and the literature was reviewed.
RESULTSThe age of patients ranged from 2 to 77 years (mean = 43.3 years). The male-to-female ratio was 1.5:1. Major clinical presentations included superficial lymph node enlargement and painful soft tissue mass. Follow-up data were available in 18 patients; and 14 of them died of tumor-related diseases. The average duration of survival of the patients was 16.9 months. Histologically, the tumor cells were relatively uniform in appearance and small to medium in size. The cytoplasm was scanty and pale in color. The nuclei were round or focally irregular, with fine chromatin and inconspicuous nucleoli. Mitosis figures were readily identified. Scattered immature eosinophilic myelocytes were seen. Immunohistochemical study showed that the tumor cells in all cases expressed MPO and CD43. Most cases were also positive for CD68, lysozyme, CD99 and TdT. The staining for CD3, CD20, CD79a, pan-cytokeratin and PLAP were negative.
CONCLUSIONSGranulocytic sarcoma is a known histologic mimicker of non-Hodgkin lymphoma, Ewing sarcoma/PNET and embryonal rhabdomyosarcoma. Detailed morphologic examination, when coupled with immunohistochemical study, is useful in arriving at a correct diagnosis.
Adolescent ; Adult ; Aged ; Burkitt Lymphoma ; metabolism ; pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Leukosialin ; metabolism ; Lymph Nodes ; pathology ; Male ; Middle Aged ; Muscle Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Ovarian Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Peroxidase ; metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; metabolism ; pathology ; Retrospective Studies ; Sarcoma, Ewing ; metabolism ; pathology ; Sarcoma, Myeloid ; drug therapy ; metabolism ; pathology ; surgery ; Skin Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Survival Rate ; Young Adult
8.Recurrent follicular dendritic cell sarcoma in abdomen: report of a case.
Jing LIU ; Rui ZHANG ; Zheng-long ZHU ; Peng CAO ; Xia LI ; Ping ZHOU ; Wei ZHANG
Chinese Journal of Pathology 2010;39(10):709-710
Abdominal Neoplasms
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drug therapy
;
metabolism
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pathology
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secondary
;
surgery
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Dendritic Cell Sarcoma, Follicular
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drug therapy
;
metabolism
;
pathology
;
surgery
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Dendritic Cell Sarcoma, Interdigitating
;
metabolism
;
pathology
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Diagnosis, Differential
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Female
;
Gastrointestinal Stromal Tumors
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metabolism
;
pathology
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Histiocytoma, Malignant Fibrous
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metabolism
;
pathology
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Humans
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Middle Aged
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Neoplasm Recurrence, Local
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Omentum
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Peritoneal Neoplasms
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secondary
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Receptor, Epidermal Growth Factor
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metabolism
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Receptors, Complement 3b
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metabolism
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Receptors, Complement 3d
;
metabolism
9.AIDS-related Gastrointestinal Kaposi Sarcoma in Korea: A Case Report and Review of the Literature.
Cho Yun CHUNG ; Sang Woo PARK ; Eun MYUNG ; Dong Keun CHO ; Young A SONG ; Kang Jin PARK ; Hee Chang JANG ; Young Eun JOO
The Korean Journal of Gastroenterology 2012;60(3):166-171
Kaposi sarcoma (KS) is a vascular neoplasm, which is fairly prevalent in acquired immunodeficiency syndrome (AIDS) patients. Mucocutaneous and lymph node involvements are characteristic features of KS in AIDS patients. The involvement of gastrointestinal tract occurs in 40% of KS patients and leads to significant morbidity and mortality. In the highly active antiretroviral therapy (HAART) era, the rate of AIDS related KS has fallen with control of human immunodeficiency virus (HIV) viremia. However, it is still recognized as the primary AIDS-defining illness, and the proportion of AIDS diagnoses made due to KS ranged from 4.1% to 7.5%. In Korea, AIDS-related KS has been report in low rate incidence. Its gastrointestinal involvements are rarely reported. To date, five cases have been recorded in Korea. Herein, we present an additional case of gastrointestinal KS as the AIDS-defining illness and review of the Korean medical literature.
Acquired Immunodeficiency Syndrome/complications/*diagnosis
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Anti-HIV Agents/therapeutic use
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Endoscopy, Digestive System
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HIV Infections/complications/diagnosis/drug therapy
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Humans
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Male
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Middle Aged
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Republic of Korea
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Sarcoma, Kaposi/*diagnosis/etiology/pathology
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Tomography, X-Ray Computed
10.Extranodal follicular dendritic cell sarcoma of neck region: report of a case.
Chinese Journal of Pathology 2012;41(6):410-411
Antineoplastic Combined Chemotherapy Protocols
;
therapeutic use
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Carcinoma
;
metabolism
;
pathology
;
Cyclophosphamide
;
therapeutic use
;
Dendritic Cell Sarcoma, Follicular
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Diagnosis, Differential
;
Doxorubicin
;
therapeutic use
;
Head and Neck Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Humans
;
Lung Neoplasms
;
drug therapy
;
secondary
;
Male
;
Melanoma
;
metabolism
;
pathology
;
Middle Aged
;
Neoplasm Recurrence, Local
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Prednisone
;
therapeutic use
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Receptors, Complement 3b
;
metabolism
;
Receptors, Complement 3d
;
metabolism
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Vincristine
;
therapeutic use