Diagnosis, Differential ; Humans ; Sarcoma, Myeloid/diagnosis*

Humans ; Sarcoma, Myeloid ; diagnosis ; Skull ; pathology

Adult ; Female ; Humans ; Sarcoma, Myeloid ; diagnosis ; Vulvar Neoplasms ; diagnosis

Adult ; Female ; Humans ; Sarcoma, Myeloid ; diagnosis ; Uterine Cervical Neoplasms ; diagnosis

An isolated granulocytic sarcoma (chloroma) of the left ovary occured in the absence of leukemia in a 12-year-old woman. This lesion is defined as a localized tumor mass composed of immature cells of the granulocytic series. Granulocytic sarcomas can occur at extramedullary sites including ovary but, isolated myelosarcoma in the absence of usual manifestations of AML may be rare and has some difficulties in diagnosis. Contrary to findings in other series, granulocytic sarcoma arising in this nonleukemic patient did not progress to acute leukemia during two years she has been followed.
Child ; Diagnosis ; Female ; Humans ; Leukemia ; Ovary* ; Sarcoma, Myeloid*

It is uncommon for acute myelogenous leukemia to present a symptom referrable to a tumor mass. A rare case of spinal epidural granulocytic sarcoma preceding the diagnosis of acute myelogenous leukemia is described. Also, reports of acute myelogenous leukemia associated with facial palsy have been extremely rare. We report a patient who had facial nerve paralysis and polyradiculomyelopathy due to granulocytic sarcoma as the presenting symptoms of acute myeloid leukemia.
Diagnosis ; Facial Nerve ; Facial Paralysis* ; Humans ; Leukemia, Myeloid, Acute* ; Paralysis ; Sarcoma, Myeloid

Granulocytic sarcoma is a rare extramedullary tumor composed of immature granulocytic precursors. Usually, granulocytic sarcoma is seen in association with acute myeloid leukemia, or other myeloproliferative disorders. Rarely, it may manifest as a primary presentation before the onset of systemic disease in acute myeloid leukemia. The clinical suspicion of granulocytic sarcoma based on imaging findings is important for the management of the patient especially when systemic disease of acute myeloid leukemia is not confirmed as in our case. We report the MR findings of a granulocytic sarcoma in the left leg mimicking hemorrhagic abscess in a patient with acute myeloid leukemia. We believe that MRI can be a helpful diagnostic method of making a differential diagnosis of granulocytic sarcoma in a patient with leukemia, and this can be done by analyzing the signal intensity and the enhancement pattern.
Abscess ; Diagnosis, Differential ; Humans ; Leg ; Leukemia ; Leukemia, Myeloid, Acute ; Myeloproliferative Disorders ; Sarcoma, Myeloid

Myeloid sarcoma is a rare condition that's caused by the aggregation of immature myeloid cells in leukemic patients. Myeloid sarcoma occurring in the temporal bone more frequently involves the mastoid bone than is the case for metastatic lesions arising from non-systemic malignancies. The disease is difficult to diagnose when it presents with symptoms that mimic otomastoiditis. However, an early diagnosis is important in order to achieve complete remission of the disease. Magnetic resonance imaging of the temporal bone is useful for making the diagnosis of myeloid sarcoma, and especially to evaluate the extent of disease. High-dose radio- or chemotherapies are the first-line approaches and possibly the only approaches to achieve complete remission and to cure the disease. With the aim of improving our understanding of myeloid sarcoma in the temporal bone, the present report describes our experience with 5 such cases and we compare the clinical features of these 5 patients with those clinical features of patients who have metastatic lesions.
Early Diagnosis ; Humans ; Hydrazines ; Magnetic Resonance Imaging ; Mastoid ; Myeloid Cells ; Sarcoma, Myeloid ; Temporal Bone

PURPOSE: We report a case of the granulocytic sarcoma located at the conjunctival fornix in a 10-year-old girl with acute myeloid leukemia, who was in complete remission after bone marrow transplantation. METHODS: A 10-year-old girl had a 1-week history of firm, dark brown conjunctival mass at lower fornix and mild lid swelling of the right eye. Several months previously she had had some chalazions at lower lid and a history of acute myeloid leukemia that was currently in complete remission after bone marrow transplantation. Other ocular manifestations were not specific. Excision of the conjunctival mass and a biopsy for diagnostic and therapeutic purposes were performed. RESULTS: The 12 x 6 x 5 mm-sized mass was totally excised. The pathologic examination was consistent with granulocytic sarcoma. Three weeks after the biopsy, the patient had a relapse of acute myeloid leukemia. She died 2 months later while undergoing intensive therapy. CONCLUSIONS: This condition should be considered in the diagnosis of granulocytic sarcoma in patients with a history of acute myeloid leukemia.
Biopsy ; Bone Marrow Transplantation ; Chalazion ; Child ; Conjunctiva* ; Diagnosis ; Female ; Humans ; Leukemia, Myeloid, Acute ; Recurrence ; Sarcoma, Myeloid*

The granulocytic sarcoma is a rare tumor and occurs primarily in patients with acute myelogenous leukemia (AML). The granulocytic sarcoma can arise before, concurrent with, or following acute myeloid leukemia. This tumor can be rarely represented as the initial presentation of acute myeloid leukemia without any signs or symptoms of leukemia. Granulocytic sarcoma, rarely, can also occur in unexpected regions, including the head and neck. This tumor is very often misdiagnosed as a malignant lymphoma which leads to inappropriate treatment and poor outcome. Therefore, clinical, histopathological and immumohistochemical findings should be evaluated before any diagnosis of malignant lymphoma. We report, with a brief review of literature, a case of granulocytic sarcoma presenting as a head and neck neoplasm.
Diagnosis ; Head* ; Humans ; Leukemia ; Leukemia, Myeloid, Acute ; Lymphoma ; Neck* ; Sarcoma, Myeloid*