Introduction: Acquired immunodeficiency syndrome-Kaposi sarcoma (AIDS-KS) has unique clinical characteristics, often dis- seminated on presentation, a rapidly progressive course, and often fatal outcome. Describing the epidemiology and clinical characteristics of AIDS-KS in the Philippines may lead to early recognition, diagnosis, and management of this condition, which are the keys to preventing significant complications. Case Series: AIDS-KS in 11 Filipino MSM patients with a mean age of 36.55 years (SD 11.54) was described. Violaceous plaques and nodules were present for an average of 5.1 months prior to diagnosis confirmed by biopsy. Histopathologic findings from all pa- tients were consistent with KS. The median CD4+ count of patients was 44 cells/microliter (range, 4 to 181). Six patients presented with opportunistic infections (OI)/AIDS-related conditions (ARC). The most common OIs observed were pulmonary tuberculosis, oropharyngeal candidiasis, and Pneumocystis jiroveci pneumonia. Nine patients improved with highly active antiretroviral therapy (HAART). One patient required modification on his HAART regimen, which was shifted to 2 NRTI and ritonavir-boosted protease inhibitor, and one patient died due to AIDS-related complications. Conclusion This series of 11 cases of AIDS-KS showed similar demographic, clinical and histopathologic characteristics to pre- viously published studies. Findings suggest the need for earlier recognition and diagnosis. While HAART afforded clinical improve- ment in a majority of patients, other treatment options such as chemotherapy should be considered for appropriate patients.
Sarcoma, Kaposi ; Antiretroviral Therapy, Highly Active

Kaposi's sarcoma (KS) appears to develop in association with kidney transplantation, but unlikely with dialysis. We report two cases of classic KS that occurred in patients receiving short-term (less than 3 yr) dialysis. They have been suffering from chronic renal failure due to tuberculosis and diabetes mellitus, respectively. Several to multiple, reddened-violaceous patches, plaques and nodules were found on the hand and the lower extremities. Laboratory studies showed no evidence suggesting immunosuppressed state and there was no history of taking immunosuppressive agents. The biopsies of the two cases revealed proliferation of spindle-shaped cells focally arranged in bundles and multiple dilated vascular spaces outlined by an attenuated endothelium with intravascular and extravasated erythrocytes. The specimens expressed positivity with CD34 antigen. Human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) was detected in one case by polymerase chain reaction method.
Aged ; Case Report ; Herpesvirus, Kaposi Sarcoma-Associated/isolation & purification ; Human ; Kidney Transplantation/adverse effects ; Male ; Middle Age ; Renal Dialysis/adverse effects* ; Sarcoma, Kaposi/virology ; Sarcoma, Kaposi/therapy ; Sarcoma, Kaposi/etiology*

Kaposi's sarcoma(KS) occurs in four distinct subsets: classic, African-endemic, iatrogenic immunosuppressive drug-associated, and AIDS-associated KS. Only two cases of AIDS-associated KS have been reported in Korea. The pathogenesis remains unclear but, suggested the relevance to the association of virus infection with KS, especially human herpesvirus-8. We report a case of an AIDS-related KS that human herpesvirus-8 DNA is present in the KS tissue. The patient was diagnosed with AIDS in 1993 and had complained of disseminated erythematous to purplish colored papulonodules on the face, neck, chest and back for 5months. He was treated with systemic cytotoxic chemotherapy, but died due to septic condition.
DNA ; Drug Therapy ; Herpesvirus 8, Human ; Humans ; Korea ; Neck ; Sarcoma, Kaposi* ; Thorax

Kaposi's sarcoma is an unusual neoplasm that has proved to be an enigma in many ways since its original description by Kaposi in 1872. Of the several different type of Kaposi's sarcoma, iatrogenically immunosuppressed patients predisposed to Kaposi's sarcoma are usually either transplant recipients or patients receiving immunosuppressive therapy. We report a case of recurrent Kaposi's sarcoma in a 56 year old male, which has occurred during the cyclosporine therapy of kidney transplantation. Cyclosporine was discontinued and chemotherapy began and the resolution of Kaposi's sarcoma has been obtained. Cyclosporine maintenance therapy was started again for the prevention of graft rejection. But 1 year later, Kaposi's sarcoma recurred probably due to re-use of cyclosporine.
Cyclosporine* ; Drug Therapy ; Graft Rejection ; Humans ; Kidney Transplantation* ; Kidney* ; Male ; Middle Aged ; Sarcoma, Kaposi* ; Transplantation

Kaposi sarcoma (KS) has attracted much attention recently because of its high incidence among patients with acquired immune deficiency syndrome. Other groups with a high risk of developing KS are renal transplant recipients treated with immunosuppressive drugs and, to a lesser extent, patients with autoimmune diseases. We report the case of a patient who developed KS during corticosteroid therapy for idiopathic thrombocytopenic purpura, which subsequently regressed with combination chemotherapy.
Acquired Immunodeficiency Syndrome ; Autoimmune Diseases ; Drug Therapy, Combination ; Humans ; Incidence ; Purpura, Thrombocytopenic, Idiopathic* ; Sarcoma, Kaposi* ; Transplantation

Radiation recall dermatitis is a rare skin reaction, occurring subsequent to drug administration, and has all the clinical signs of inflammation, which develop in a previously irradiated area, days to years after exposure to ionizing radiation. A 41-year-old woman was diagnosed with Kaposi sarcoma. The patient was treated by radiotherapy, followed by a 1st chemotherapy session with doxorubicin and ifosfamide, 20 days after the radiotherapy. However, the patient developed erythema of the skin, accompanied by pruritus and pain in the previously irradiated area, 3 to 4 days after the chemotherapy. The erythema resolved almost completely after systemic and topical steroid therapy. The patient received a 2nd chemotherapy session with the same regimen, but there was no recurrence of radiation recall dermatitis. We report a case of an uncommon skin reaction after chemotherapy in a patient with kaposi sarcoma, which was identified as radiation recall dermatitis.
Adult ; Doxorubicin ; Drug Therapy ; Erythema ; Female ; Humans ; Ifosfamide ; Inflammation ; Pruritus ; Radiation, Ionizing ; Radiodermatitis* ; Radiotherapy ; Recurrence ; Sarcoma, Kaposi* ; Skin

Radiation recall dermatitis is a rare skin reaction, occurring subsequent to drug administration, and has all the clinical signs of inflammation, which develop in a previously irradiated area, days to years after exposure to ionizing radiation. A 41-year-old woman was diagnosed with Kaposi sarcoma. The patient was treated by radiotherapy, followed by a 1st chemotherapy session with doxorubicin and ifosfamide, 20 days after the radiotherapy. However, the patient developed erythema of the skin, accompanied by pruritus and pain in the previously irradiated area, 3 to 4 days after the chemotherapy. The erythema resolved almost completely after systemic and topical steroid therapy. The patient received a 2nd chemotherapy session with the same regimen, but there was no recurrence of radiation recall dermatitis. We report a case of an uncommon skin reaction after chemotherapy in a patient with kaposi sarcoma, which was identified as radiation recall dermatitis.
Adult ; Doxorubicin ; Drug Therapy ; Erythema ; Female ; Humans ; Ifosfamide ; Inflammation ; Pruritus ; Radiation, Ionizing ; Radiodermatitis* ; Radiotherapy ; Recurrence ; Sarcoma, Kaposi* ; Skin

Kaposis sarcoma is well recognized in patient,s with imrnunodef cienicy states such as organ trans plantation, malignancy, and acquired irnmunodeficiency syndrome(tILS). Kaposis sarcorna associated with organ transplantation is, however relatively uncomrnon in Konea. We report a case of Kaposi's sarcorna in a 23 year old male kidney recipient., who was on cyclosporine and prednisolone. The tumor involved the larynx and long as well as the skin. He was treated with radiation therapy and chemotherapy, and the dosage of immunosupressants were reduced.
Cyclosporine ; Drug Therapy ; Humans ; Kidney Transplantation* ; Kidney* ; Larynx ; Male ; Organ Transplantation ; Prednisolone ; Sarcoma, Kaposi* ; Skin ; Transplants ; Young Adult

A 24 year-old Korean male, has had an eruption on the Lt. foot for 3 years. The lesion consists of single large macule of reddish purplish brown coloration scattered over the great toe, dorsum and inner part of the Lt. foot. Recently, there is no new lesions and lymphadenopathy on any part of the body. Laboratory tests were all negative, including serology. X-ray findings of the chest and Lt. foot showed normal limits but, angiographic findings which was performed under the local anesthesia through the femoral artery showed the arterio-venous plexus and markedly increased vascularity on the inner side of Lt foot area. Biopsy of a macule on the inner part of the Lt. foot was confirmed as Kaposi's sarcoma. X-ray therapy (100Kv at 50cm distance with 2 mm of AL. filter) was directed to the involved sites daily for 6 days to a total of 1,800 roentogens, after lesion was progressively improved day by day.
Anesthesia, Local ; Biopsy ; Femoral Artery ; Foot ; Humans ; Lymphatic Diseases ; Male ; Sarcoma, Kaposi* ; Thorax ; Toes ; X-Ray Therapy ; Young Adult

Kaposi's sarcoma, a rare tumor, usually presents itself with skin lesions. However, extracutaneous lesions are common and the gastrointestinal tract is often involved. Gastric Kaposi's sarcoma is usually asymptomatic, but may cause massive gastrointestinal hemorrhage, perforation, intestinal obstruction, intussusception, protein-losing enteropathy, or sepsis. The gastroscopic appearances of Kaposi's sarcoma range from reddish purple maculopapules to polypoid, umbilicated nodules. In Korea, only one case of gastric Kaposi's sarcoma had been reported until now. A case of gastric Kaposi's sarcoma treated with VP-16 (etoposide) is here in reported with the endoscopic findings before and after chemotherapy.
Drug Therapy ; Etoposide* ; Gastrointestinal Hemorrhage ; Gastrointestinal Tract ; Intestinal Perforation ; Intussusception ; Korea ; Protein-Losing Enteropathies ; Sarcoma, Kaposi* ; Sepsis ; Skin