1.Clinicopathological features of congenital hemangioma: a study of 40 cases.
Dong LIANG ; Bo ZHOU ; Na LI ; Ling Fei KONG ; Qiu Yu LIU ; Yan Zhi DING ; Kuai Lin NIU ; Xiao Shuang ZHU ; Hao Hui ZHU
Chinese Journal of Pathology 2022;51(3):202-206
Objective: To investigate the clinical and pathologic features, diagnosis and differential diagnosis of congenital hemangioma (CH). Methods: Forty cases of CH were diagnosed from January 2017 to December 2020 in Henan Provincial People's Hospital. The clinical and pathological and immunohistochemical data were analyzed, with review of literature. Results: There were 24 male and 16 female patients. The lesions were located in the head, neck (11 cases), limbs (14 cases), and trunk (15 cases). The clinical manifestations were congenital painless plaques or masses, the larger ones protruded on the skin surface, mostly dusky purple or bright red, with surrounding white halos. Under low magnification, the tumor was lobular and well demarcated, composed of neo-microvascular lumen of different sizes. The vascular endothelial cells were cuboidal or hobnail in appearance, forming stellar drainage vessels within the lobules. Extra-medullary hematopoiesis was seen in one case of rapidly involuting CH; there were different number of tortuous and dilated vascular lumen between the lobular structures, and some non-involuting CH cases were vascular malformations, which were devoid of lobulated structures. Immunohistochemistry showed that endothelial cells were strongly positive for CD31, CD34 and ERG, while D2-40 and GLUT-1 were negative. Conclusions: CH is a benign congenital vascular tumor with characteristic lobulated growth and abnormal blood vessels in the stroma. Pathological diagnosis often needs to be differentiated from infantile hemangioma, pyogenic granuloma, kaposiform hemangioendothelioma and vascular malformation.
Endothelial Cells/pathology*
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Female
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Hemangioendothelioma/pathology*
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Hemangioma/pathology*
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Humans
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Kasabach-Merritt Syndrome/pathology*
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Male
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Sarcoma, Kaposi/pathology*
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Skin Neoplasms/pathology*
2.Clinicopathologic features of kaposiform hemangioendothelioma.
Hong-feng TANG ; Yuan-yuan ZHOU ; Wei-zhong GU ; Min-ju LI
Chinese Journal of Surgery 2004;42(18):1132-1135
OBJECTIVETo explore the clinicopathologic features of kaposiform hemangioendothelioma (KHE).
METHODSThe clinicopathologic data were studied in three cases of KHE and review the literatures.
RESULTSTwo cases were female and one was male. All cases occurred in infancy. Two tumor located in axillary chest wall and one in lumbar region. All of the three patients had Kasabach-Merritt syndrome. Histologically, the tumor was composed of spindle-shaped cells. in all cases nodular growth pattern was seen. Immunohistochemically, Neoplastic spindled cells expressed CD34 and CD31. Associated lymphangiomatosis was present in two cases. Two tumors were resected completely, one was resected partly. the follow-up period ranged from 6 months to 3 years, and all were alive.
CONCLUSIONSKaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that mainly occurred in early infancy. It is frequently complicated by Kasabach-Merritt syndrome, and it has features common to both capillary hemangioma and Kaposi sarcoma. The prognosis of KHE is determined by the size, location and the hemorrhage degree of vascular tumor. Better outcome might be achieved in patients with KHE of the skin and in the soft tissues under the skin. It appears that the main treated measure should be wide local excision.
Diagnosis, Differential ; Female ; Hemangioendothelioma ; complications ; pathology ; Humans ; Infant ; Male ; Purpura, Thrombocytopenic ; etiology ; Sarcoma, Kaposi ; complications ; pathology ; Skin Neoplasms ; complications ; pathology
4.One case of nasal Kaposiform hemangioendothelioma.
Jian ZANG ; Qian LIU ; Xuejun JIANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(4):373-375
Female patients, 41 years old, with the left nasal cavity bleeding intermittently and left nasal congestion 20 days as the chief complaint to the hospital. Physical examinationindicated dark red mass was at the front-end of left nasal cavity, which has not smooth surface with blood vessels and hemorrhagic secretions, and back up to the middle turbinate. Sinus enhancement 3D-CT showed soft tissue density can be found in the left nasal cavity,Scan CT value is 37-47 HU, and enhanced and delay is about 69-78 HU. Nasal septum,middle turbinate and inferior turbinate bonewas visible damage. The pathologic biopsy of left nasal cavity lesions results conform to the Kaposiform hemangioendothelioma.
Adult
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Female
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Hemangioendothelioma
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pathology
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Humans
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Kasabach-Merritt Syndrome
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pathology
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Nasal Septum
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Paranasal Sinuses
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Sarcoma, Kaposi
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pathology
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Tomography, X-Ray Computed
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Turbinates
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pathology
5.Detection of human herpes virus 8 in Kaposi sarcoma using polymerase chain reaction and single stranded probe in situ hybridization with a tyramide signal amplification system.
Xiaoge ZHOU ; Jinsong ZHANG ; Xiaoping ZHANG ; Ye ZHANG ; Kristian SANDVEJ ; Stephen HAMILTON-DUTOIT
Chinese Journal of Pathology 2002;31(4):309-313
OBJECTIVETo study the relationship between Kaposi's sarcoma (KS) and human herpes virus 8 (HHV8; Kaposi's sarcoma-associated herpes virus), and to develop an in situ hybridization (ISH) technique effective for clinical pathological diagnosis.
METHODSPolymerase chain reaction (PCR) technique was used to synthesize a digoxigenin-labeled single stranded DNA probe specific for HHV8 open reading frame 72 cyclin D homolog gene encoded mRNA as the probe accompanying with a tyramide signal amplification system (TSA) for ISH assay. Totally 20 formalin-fixed and paraffin-embedded samples from 14 cases of KS from Danish patients were collected for HHV8 detection. In order to compare the result obtained, all of these cases were checked simultaneously using PCR technique.
RESULTSHHV8 was detected in 10 of 14 (71%) KS cases, of which 8 cases were positive for HHV8 by both ISH and PCR. In ISH, HHV8 hybridization signal was seen as a dot or patch located in the nuclei of both the neoplastic spindle cells and the endothelial cells. HHV8 was found in lesions in all the stages of KS including early patch, plaque and late nodular or tumor lesions, as well as in the primary and metastatic lesions. All the control cases showed a relevant positive or negative results.
CONCLUSIONSThe results further confirmed that there is a strong association between Kaposi's sarcoma and HHV8. The ISH technique with single stranded probe and TSA would be helpful in clinical pathological diagnosis for HHV8 infected diseases, such as KS, primary effusion lymphoma and multicentric Castleman's disease.
Adolescent ; Adult ; Female ; Herpesvirus 8, Human ; isolation & purification ; Humans ; In Situ Hybridization ; methods ; Male ; Middle Aged ; Polymerase Chain Reaction ; methods ; Sarcoma, Kaposi ; pathology ; virology ; Tyramine
6.AIDS associated Kaposi's sarcoma of the stomach.
Ying-yong HOU ; Yun-shan TAN ; Shao-hua LU ; Jian-fang XU ; Yan-nan ZHOU ; Sujie AKESU ; Hai-ying ZENG ; Feng GAO ; Xiong-zeng ZHU
Chinese Journal of Pathology 2005;34(3):191-192
Acquired Immunodeficiency Syndrome
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complications
;
pathology
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Antigens, CD34
;
metabolism
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Gastrectomy
;
methods
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Humans
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Male
;
Middle Aged
;
Sarcoma, Kaposi
;
metabolism
;
pathology
;
surgery
;
virology
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Stomach
;
pathology
;
Stomach Neoplasms
;
metabolism
;
pathology
;
surgery
;
virology
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Vimentin
;
metabolism
7.Microvenular hemangioma: report of a case.
Qian-he LIAO ; Hui-min AN ; Sheng-hua PAN ; Wei-hua LI
Chinese Journal of Pathology 2013;42(7):474-475
Actins
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metabolism
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Antigens, CD34
;
metabolism
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Diagnosis, Differential
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Female
;
Hemangioma
;
metabolism
;
pathology
;
surgery
;
Hemangiosarcoma
;
pathology
;
Humans
;
Middle Aged
;
Platelet Endothelial Cell Adhesion Molecule-1
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metabolism
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Sarcoma, Kaposi
;
pathology
;
Skin Neoplasms
;
metabolism
;
pathology
;
surgery
;
Vimentin
;
metabolism
8.Spindle cell hemangioma in frontal bone: report of a case.
Tao-ying ZENG ; Jun FAN ; Bei LIU ; Qiong WANG
Chinese Journal of Pathology 2010;39(2):120-121
Adult
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Antigens, CD34
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metabolism
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Diagnosis, Differential
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Female
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Frontal Bone
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Hemangioma
;
metabolism
;
pathology
;
surgery
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Hemangioma, Cavernous
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pathology
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Humans
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Platelet Endothelial Cell Adhesion Molecule-1
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metabolism
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Sarcoma, Kaposi
;
metabolism
;
pathology
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Skull Neoplasms
;
metabolism
;
pathology
;
surgery
9.Kaposi sarcoma after bone marrow transplantation: report of a case.
Yu CHEN ; Yan-hui LIU ; Ying FENG ; Heng-guo ZHUANG ; Xin-lan LUO
Chinese Journal of Pathology 2011;40(2):125-126
Abdominal Cavity
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Adult
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Anemia, Aplastic
;
therapy
;
Antigens, CD34
;
metabolism
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Carcinoma
;
metabolism
;
pathology
;
Dendritic Cell Sarcoma, Follicular
;
metabolism
;
pathology
;
Diagnosis, Differential
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Hematopoietic Stem Cell Transplantation
;
adverse effects
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Humans
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Ki-67 Antigen
;
metabolism
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Lymph Nodes
;
pathology
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Male
;
Neoplasms, Muscle Tissue
;
metabolism
;
pathology
;
Platelet Endothelial Cell Adhesion Molecule-1
;
metabolism
;
Sarcoma, Kaposi
;
etiology
;
metabolism
;
pathology
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Viral Proteins
;
metabolism
10.AIDS-related Gastrointestinal Kaposi Sarcoma in Korea: A Case Report and Review of the Literature.
Cho Yun CHUNG ; Sang Woo PARK ; Eun MYUNG ; Dong Keun CHO ; Young A SONG ; Kang Jin PARK ; Hee Chang JANG ; Young Eun JOO
The Korean Journal of Gastroenterology 2012;60(3):166-171
Kaposi sarcoma (KS) is a vascular neoplasm, which is fairly prevalent in acquired immunodeficiency syndrome (AIDS) patients. Mucocutaneous and lymph node involvements are characteristic features of KS in AIDS patients. The involvement of gastrointestinal tract occurs in 40% of KS patients and leads to significant morbidity and mortality. In the highly active antiretroviral therapy (HAART) era, the rate of AIDS related KS has fallen with control of human immunodeficiency virus (HIV) viremia. However, it is still recognized as the primary AIDS-defining illness, and the proportion of AIDS diagnoses made due to KS ranged from 4.1% to 7.5%. In Korea, AIDS-related KS has been report in low rate incidence. Its gastrointestinal involvements are rarely reported. To date, five cases have been recorded in Korea. Herein, we present an additional case of gastrointestinal KS as the AIDS-defining illness and review of the Korean medical literature.
Acquired Immunodeficiency Syndrome/complications/*diagnosis
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Anti-HIV Agents/therapeutic use
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Endoscopy, Digestive System
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HIV Infections/complications/diagnosis/drug therapy
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Humans
;
Male
;
Middle Aged
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Republic of Korea
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Sarcoma, Kaposi/*diagnosis/etiology/pathology
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Tomography, X-Ray Computed