1.A case of endometrial stromal sarcoma.
Sam Yeol PARK ; Mi Ae PARK ; Soon Chul JEONG ; Jeon Joo LIM ; Hyuck Seok PARK
Korean Journal of Obstetrics and Gynecology 1991;34(4):589-593
No abstract available.
Sarcoma, Endometrial Stromal*
2.Treatment of Low Grade Endometrial Stromal Sarcoma.
Ji Hoon KIM ; Chae Chun RHIM ; Sung Eun NAMKOONG
Korean Journal of Obstetrics and Gynecology 2002;45(12):2289-2294
OBJECTIVE: The aim of this study was to obtain information on the prognosis and treatment of the low grade endometrial stromal sarcoma. PATIENTS AND METHODS: Three patients with low grade endometrial stromal sarcoma treated in kangnam St. Mary's hospital between 1993 and 2002 were evaluated. The clinical stage, management and outcome were analyzed. RESULTS: Those patients with low grade endometrial stromal sarcoma had a long overall survival in the presence of receiving hormonal therapy after initial surgery. Two are alive with disease-free status, one has shown a partial response to hormonal treatment. CONCLUSION: Surgery is the primary treatment for low grade endometrial stromal sarcoma. High dose hormonal replacement as adjuvant therapy will be associated with a lengthened overall survival in patients with low grade endometrial stromal sarcoma.
Humans
;
Prognosis
;
Sarcoma, Endometrial Stromal*
3.Two Cases of Low-Grade Endometrial Stromal Sarcoma.
Jung Han KIM ; Dong Kyu KIM ; Jong Hwa KIM ; Hee Jin PARK ; Young Sun AHN
Korean Journal of Obstetrics and Gynecology 2002;45(11):2048-2052
Endometrial stromal sarcomas are rare uterine tumors accounting for about 0.2% of female genital tract malignancies, which are composed of cells closely resembling normal proliferative endometrial stromal cells. The tumor is classified into a low-grade and a high-grade variety on the basis of the mitotic rate. The low- grade endometrial stromal sarcoma has many synonyms, which include endolymphatic stromal myosis, stromatosis, stromal endometriosis and endometrioid sarcoma. Because the endometrial stromal sarcoma is very rare, the preoperative diagnosis and postoperative treatment are still difficult for clinicians. We have experienced two cases of low-grade endometrial stromal sarcoma of the uterus which are presented with a review of brief literature.
Diagnosis
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Endometrial Stromal Tumors
;
Endometriosis
;
Female
;
Humans
;
Sarcoma
;
Sarcoma, Endometrial Stromal*
;
Stromal Cells
;
Uterus
4.Two Cases of Low-Grade Endometrial Stromal Sarcoma.
Jung Han KIM ; Dong Kyu KIM ; Jong Hwa KIM ; Hee Jin PARK ; Young Sun AHN
Korean Journal of Obstetrics and Gynecology 2002;45(11):2048-2052
Endometrial stromal sarcomas are rare uterine tumors accounting for about 0.2% of female genital tract malignancies, which are composed of cells closely resembling normal proliferative endometrial stromal cells. The tumor is classified into a low-grade and a high-grade variety on the basis of the mitotic rate. The low- grade endometrial stromal sarcoma has many synonyms, which include endolymphatic stromal myosis, stromatosis, stromal endometriosis and endometrioid sarcoma. Because the endometrial stromal sarcoma is very rare, the preoperative diagnosis and postoperative treatment are still difficult for clinicians. We have experienced two cases of low-grade endometrial stromal sarcoma of the uterus which are presented with a review of brief literature.
Diagnosis
;
Endometrial Stromal Tumors
;
Endometriosis
;
Female
;
Humans
;
Sarcoma
;
Sarcoma, Endometrial Stromal*
;
Stromal Cells
;
Uterus
5.A case of primary retroperitoneal undifferentiated endometrial stromal sarcoma after concurrent chemoradiation therapy for cervical cancer.
Woo Dae KANG ; Cheol Hong KIM ; Moon Kyung CHO ; Jong Woon KIM ; Yoon Ha KIM ; Ho Sun CHOI ; Seok Mo KIM
Journal of Gynecologic Oncology 2008;19(2):150-153
Endometrial stromal sarcoma (ESS) is a relatively rare uterine sarcoma, especially extrauterine ESS. Furthermore, retroperitoneal ESS are extremely rare. Up to now, there are only four cases of primary retroperitoneal ESS reported in the literature. We report one case of primary retroperitoneal undifferentiated endometrial stromal sarcoma after concurrent chemoradiation therapy for cervical cancer with a brief review of the literature.
Retroperitoneal Space
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Sarcoma
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Sarcoma, Endometrial Stromal
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Uterine Cervical Neoplasms
6.Diagnostic Utility of the JAZF1/JJAZ1 Gene Fusion in Endometrial Stromal Sarcomas and Their Histologic Variants.
Sang Ryung LEE ; Joon Seon SONG ; Ga Hye KIM ; Jene CHOI ; Hyung Kyoung KIM ; Yonghee LEE ; Kyu Rae KIM
Korean Journal of Pathology 2011;45(5):498-505
BACKGROUND: The diagnosis of endometrial stromal sarcoma (ESS) is often difficult in cases showing diverse histological differentiation or in undifferentiated endometrial sarcoma (UES). Recently, JAZF1/JJAZ1 gene fusion has been described as a defining feature of low-grade ESS (LGESS). However, its prevalence is variably reported, and the diagnostic utility has rarely been examined for cases showing various histological differentiation. METHODS: To test the diagnostic utility of JAZF1/JJAZ1 gene fusion in difficult cases, we compared the prevalence of the JAZF1/JJAZ1 fusion gene in LGESS with and without histological differentiation. RESULTS: The JAZF1/JJAZ1 fusion transcript was detected in 18 of 21 LGESS (85.7%), including 14 classical LGESS (93%), four LGESS with diverse histological differentiation (67%), and two with UES (28.6%). Positive cases included two LGESS with sex cord-like differentiation, one with osseous differentiation, and two UES. LGESS showing smooth muscle differentiation revealed the fusion transcript only in the classic area. Direct sequencing analysis of two LGESS revealed a previously reported breakpoint at t(7;17)(p15;q21). CONCLUSIONS: The JAZF1/JJAZ1 fusion gene was identified in a significant proportion of LGESS showing secondary histological differentiation except in cases with smooth muscle differentiation. Thus, this fusion gene may be useful to confirm the diagnosis in difficult cases of LGESS.
Gene Fusion
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Muscle, Smooth
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Prevalence
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Sarcoma
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Sarcoma, Endometrial Stromal
7.A Case of Endometrial Stromal Sarcoma with Smooth Muscle Differentiation.
Si Eun LEE ; Eul Ju MOON ; Yeon Jin PARK ; Ju Won ROH ; Hee Sung KIM ; Jung Suk SIM ; Jong Du PARK ; Sang Yoon PARK
Korean Journal of Obstetrics and Gynecology 2001;44(11):2150-2154
Mixed endometrial stromal and smooth-muscle tumor is one of the uncommon forms of uterine sarcoma. Only a few cases of endometrial stromal tumors showing smooth muscle differentiation have been reported in the literature. We experienced a case of low grade endometrial stromal sarcoma with smooth muscle differentiation in a 44-year-old woman, so we report this case with brief review of literatures.
Adult
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Endometrial Stromal Tumors
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Female
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Humans
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Muscle, Smooth*
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Sarcoma
;
Sarcoma, Endometrial Stromal*
8.Ultrasonographic findings of low-grade endometrial stromal sarcoma of the uterus with a focus on cystic degeneration.
Ga Eun PARK ; Sung Eun RHA ; Soon Nam OH ; Ahwon LEE ; Keun Ho LEE ; Mee Ran KIM
Ultrasonography 2016;35(2):124-130
PURPOSE: The goal of this study was to perform a retrospective analysis of the ultrasonographic findings associated with low-grade endometrial stromal sarcoma. METHODS: Ten pathologically confirmed cases of low-grade endometrial stromal sarcoma at our institution from January 2007 to April 2014 were retrospectively reviewed. All patients underwent a preoperative transvaginal ultrasound. Two radiologists came to a consensus regarding the location, size, margin, and echogenicity of the tumor, as well as the presence of intratumoral cystic degeneration and its extent and configuration. RESULTS: Low-grade endometrial stromal sarcoma manifested as an intramural mass protruding into the endometrial cavity (n=6) or as a purely intramural mass (n=4). The maximal diameter of the lesion ranged from 4 to 9.1 cm (mean, 6.2 cm). The imaging features of low-grade endometrial stromal sarcoma were variable: six cases involved predominantly solid masses containing cystic degeneration, one was a predominantly unilocular cystic mass, two were ill-defined infiltrative solid masses, and one was a well-defined solid mass. Among the seven cases with internal cystic degeneration, five patients showed a multiseptated cystic area or a cystic area with multiple small clusters, while a unilocular cystic area within the tumor was found in two patients. CONCLUSION: Low-grade endometrial stromal sarcoma is associated with variable ultrasonographic findings with regard to the location, margin, and configuration of the lesion. Multiseptated cystic areas and multiple small areas of cystic degeneration are common.
Consensus
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Endometrial Stromal Tumors
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Humans
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Retrospective Studies
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Sarcoma
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Sarcoma, Endometrial Stromal*
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Ultrasonography
;
Uterus*
9.A case of multiple metastatic low-grade endometrial stromal sarcoma arising from an ovarian endometriotic lesion.
Joo Yeon KIM ; Seong Yeon HONG ; Hyun Jung SUNG ; Hoon Kyu OH ; Suk Bong KOH
Journal of Gynecologic Oncology 2009;20(2):122-125
The development of endometrial stromal sarcomas (ESSs) in foci of endometriosis is extremely rare, and few cases have been reported in the literature to date, particularly with regard to multiple extrauterine ESS. Here we report a case of endometrial stromal sarcoma with multiple metastasis that arose from an ovarian endometriotic lesion. The literature is also briefly reviewed.
Endometriosis
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Female
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Neoplasm Metastasis
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Ovary
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Sarcoma, Endometrial Stromal
10.3 Cases of Low-grade Endometrial Stromal Sarcoma.
Sun Hwan KOH ; Eun Seop SONG ; Se Ryun KIM ; Moon Hee LEE ; Woo Chul KIM ; Yun Seob SONG ; Jee Hyun PARK ; Moon Whan IM ; Byoung Ick LEE ; Woo Young LEE
Korean Journal of Obstetrics and Gynecology 2004;47(4):773-779
Endometrial stromal sarcomas (ESS) of the myometrium compose just 0.2% of uterine malignant tumors. In terms of their cellular mitotic activities, they are named as low grade or high grade ESS. As low grade ESS are very rare, we would like to report our 3 cases with immunohistochemical stain method, treatment option as the disease progression and the brief review of literature.
Animals
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Disease Progression
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Female
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Mice
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Myometrium
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Sarcoma, Endometrial Stromal*