2.Clinicopathologic features and prognostic factors of endometrial stromal sarcoma: a study of 55 cases.
Jing-li SHI ; Ning-hai CHENG ; Li-na GUO ; Li-juan LIAN
Chinese Journal of Pathology 2011;40(8):517-522
OBJECTIVETo investigate the clinicopathologic features and the prognostic factors of endometrial stromal sarcoma (ESS).
METHODS55 cases of endometrial stromal sarcoma were reviewed and categorized into 3 pathologic types based on the related literatures, i.e., low grade endometrial stromal sarcoma (LGESS), undifferentiated endometrial sarcoma with nuclear uniformity (UES-U) and undifferentiated endometrial sarcoma with nuclear pleomorphism (UES-P). Meanwhile, the pathologic features were reviewed, including fibroid, myoid, mucoid, and epithelioid differentiation and mitotic index. Clinical and follow-up data were collected.
RESULTSIn endometrial stromal sarcoma, two or three pathologic types co-existed in one case, including 12.8% (5/39) of LGESS, 5/9 of UES-U, and 5/7 of UES-P. Mitotic index varied in different regions of one tumor from rare to high. Multi-differentiation was also commonly seen in ESS. The numbers of cases in LGESS, UES-U and UES-P were 39, 9 and 7, with recurrence rate of 51.6% (16/31), 5/6 and 2/3, respectively. There was no death case in LGESS, and 2 cases were died in UES-U and UES-P, respectively. In the 2 death cases of UES-U, both had focus of UES-P. There was a significant difference in the recurrence rate between cases with different mitotic index (≥ 10/10 HPF and < 10/10 HPF, P = 0.009), especially in LGESS group. All death cases had high mitotic index (> 30/10 HPF).
CONCLUSIONSIt is a common phenomenon in ESS that two or three pathologic types may exist in one case, especially in UES-U and UES-P. And multi-differentiation is also commonly seen in ESS. So adequate pathologic sampling is important for pathologists to make a correct diagnosis of ESS in daily work. The recurrence rates are significantly higher in cases with high mitotic index, especially in LGESS. In addition, the presence of UES-P and high mitotic index may increase the risk of death in the patients.
Adult ; Aged ; Aged, 80 and over ; Cell Differentiation ; Endometrial Neoplasms ; classification ; pathology ; surgery ; Endometrial Stromal Tumors ; pathology ; surgery ; Female ; Follow-Up Studies ; Humans ; Hysterectomy ; Middle Aged ; Mitotic Index ; Neoplasm Recurrence, Local ; Sarcoma, Endometrial Stromal ; classification ; pathology ; surgery ; Survival Rate ; Young Adult
3.Survival outcomes of different treatment modalities in patients with low-grade endometrial stromal sarcoma.
Ming WANG ; Shi-Hui MENG ; Bo LI ; Yue HE ; Yu-Mei WU
Chinese Medical Journal 2019;132(9):1128-1132
Adult
;
Aged
;
Algorithms
;
Endometrial Neoplasms
;
metabolism
;
mortality
;
surgery
;
Female
;
Humans
;
Middle Aged
;
Receptors, Estrogen
;
metabolism
;
Sarcoma, Endometrial Stromal
;
metabolism
;
mortality
;
surgery
;
Treatment Outcome
5.Cotyledonoid hydropic intravenous leiomyomatosis of uterus: report of a case.
Ying WU ; Ju-fang CAI ; Guo-feng ZHANG ; Shou-xiang WENG ; Yi-jian YU
Chinese Journal of Pathology 2006;35(12):763-764
Adult
;
Diagnosis, Differential
;
Female
;
Humans
;
Hysterectomy
;
Leiomyomatosis
;
pathology
;
surgery
;
Sarcoma, Endometrial Stromal
;
pathology
;
Uterine Neoplasms
;
pathology
;
surgery
;
Uterus
;
blood supply
;
Vascular Neoplasms
;
pathology
;
surgery
6.The utility of the 3D imaging software in the macroscopic rendering of complex gynecologic specimens.
Luca RONCATI ; Beniamino PALMIERI ; Teresa PUSIOL ; Francesco PISCIOLI ; Michele SCIALPI ; Giuseppe BARBOLINI ; Antonio MAIORANA
Journal of Gynecologic Oncology 2015;26(2):168-169
No abstract available.
Abdomen/pathology/surgery
;
Adult
;
Endometrial Neoplasms/complications/*pathology/radiography/surgery
;
Endometriosis/complications/*pathology/radiography/surgery
;
Female
;
Humans
;
Image Enhancement/*methods
;
Imaging, Three-Dimensional/*methods
;
Pelvis/pathology/radiography/surgery
;
Radiography, Abdominal
;
Sarcoma, Endometrial Stromal/complications/*pathology/radiography/surgery
;
*Software
;
Specimen Handling
7.Long-term survival of patients with recurrent endometrial stromal sarcoma: a multicenter, observational study.
Hiroyuki YAMAZAKI ; Yukiharu TODO ; Kenrokuro MITSUBE ; Hitoshi HAREYAMA ; Chisa SHIMADA ; Hidenori KATO ; Katsushige YAMASHIRO
Journal of Gynecologic Oncology 2015;26(3):214-221
OBJECTIVE: The aim of this study was to evaluate the clinical behavior and management outcome of recurrent endometrial stromal sarcoma (ESS). METHODS: A retrospective review of charts of 10 patients with recurrent ESS was performed and relapse-free interval, relapse site, treatment, response to treatment, duration of follow-up and clinical outcome extracted. Survival outcome measures used were post-relapse survival which was defined as the time from first evidence of relapse to death from any cause. Living patients were censored at the date of last follow-up. RESULTS: The median age and median relapse-free interval at the time of initial relapse were 51.5 years and 66.5 months, respectively. The number of relapses ranged from one to five. Sixteen surgical procedures for recurrent disease included nine (56.0%) complete resections. There was no statistically significant difference between initial recurrent tumors and second/subsequent recurrent tumors in the rate of complete surgery (44.4% vs. 71.4%, respectively, p=0.36). Of the eleven evaluable occasions when hormonal therapy was used for recurrent disease, disease control was achieved in eight (72.7%). There was no difference between initial recurrent tumors and second/subsequent recurrent tumors in disease control rate by hormonal therapy (85.7% vs. 50.0%, respectively, p=0.49). The 10-year post-relapse survival rate was 90.0% and the overall median post-relapse survival 119 months (range, 7 to 216 months). CONCLUSION: Post-relapse survival of patients with ESS can be expected to be >10 years when treated by repeated surgical resection and hormonal therapy or both.
Adult
;
Aged
;
Antineoplastic Agents, Hormonal/therapeutic use
;
Chemotherapy, Adjuvant/mortality
;
Disease-Free Survival
;
Endometrial Neoplasms/drug therapy/*mortality/surgery
;
Female
;
Humans
;
Middle Aged
;
Neoplasm Recurrence, Local/*mortality
;
Retrospective Studies
;
Sarcoma, Endometrial Stromal/drug therapy/*mortality/surgery
;
Treatment Outcome
8.Endometrial stromal sarcoma complicating uterine perivascular epithelioid cell tumor: report of a case.
Chinese Journal of Pathology 2013;42(5):345-346
Actins
;
metabolism
;
Adult
;
Diagnosis, Differential
;
Endometrial Neoplasms
;
metabolism
;
pathology
;
surgery
;
Endometrial Stromal Tumors
;
metabolism
;
pathology
;
surgery
;
Female
;
Humans
;
Hysterectomy
;
Leiomyoma, Epithelioid
;
metabolism
;
pathology
;
Melanoma-Specific Antigens
;
metabolism
;
Perivascular Epithelioid Cell Neoplasms
;
metabolism
;
pathology
;
surgery
;
Receptors, Progesterone
;
metabolism
;
Sarcoma, Clear Cell
;
metabolism
;
pathology
;
Uterine Neoplasms
;
metabolism
;
pathology
;
surgery
9.Intravascular leiomyomatosis with extrarenal rhabdoid cells: report of a case.
Hongjie SONG ; Yujuan JI ; Bingyu CHEN
Chinese Journal of Pathology 2014;43(2):128-130
Actins
;
metabolism
;
Calcium-Binding Proteins
;
metabolism
;
Calmodulin-Binding Proteins
;
metabolism
;
Desmin
;
metabolism
;
Diagnosis, Differential
;
Female
;
Humans
;
Hysterectomy
;
Leiomyoma, Epithelioid
;
metabolism
;
pathology
;
Leiomyomatosis
;
metabolism
;
pathology
;
surgery
;
Leiomyosarcoma
;
pathology
;
Microfilament Proteins
;
metabolism
;
Middle Aged
;
Receptors, Estrogen
;
metabolism
;
Receptors, Progesterone
;
metabolism
;
Rhabdoid Tumor
;
metabolism
;
pathology
;
surgery
;
Sarcoma, Endometrial Stromal
;
metabolism
;
pathology
;
Uterine Neoplasms
;
metabolism
;
pathology
;
surgery
;
Vascular Neoplasms
;
metabolism
;
pathology
;
surgery
;
Veins
;
pathology
;
Vimentin
;
metabolism