Background: Acorus calamus L. was included in the Red Book of Mongolia, it was registered as a destroyed plant and it has high significance of productivity. Therefore on the base of natural resources and abundant fund of tradi¬tional medicine, it is important to study of biological and pharmacological action of medicinal plant. It is important for treatment and economy. The plant which we are studying is a valuable plant its action is widely used in decreasing high temperature, relieving pain and anti-inflammation. It’s chemical for structure and pharmacological action have not been studied in Mongolia. This became base of studying this plant. Aim: The aim is to study some of pharmacological study. We prepared dry extract and used it for our study. Objectives: 1. To study of anti-inflammatory effect of Acorus calamus L 2. To study of cholegonic and cholekinetic effect of Acorus calamus L. 3. To study of diuretic action of Acorus calamus L 4. To study of cardiovascular effect of Acorus calamus L Material and Мethods: Acorus calamus L. preparation action against inflammation by the method of Martin G.J.Winter (1954) and Cotton Fielt. Action which affects to gall secretion by Rozuet, Jousse (1980) method in com¬parison with Allochol, action which affect to urine secretion by Treindlendburg method; Action which affects to hypertension by Electrocardiogramme (ECG) 8800 apparatus. Results: Acorus calamus L. preparation is active anti inflammation, when we compared our group which used drug with control group swelling the inflammation was decreased by 95.5% in the process of experiment which was formed by Histamin. When we studied affecting action of Acorus calamus L to gall secretion it activates action of gall secretion and form of gall liver, at 120 minutes in comparison with Allochol it affects to gall secretion by 3.8%, with the group used distilled water by 22.2%, when we studied affect to urine secretion in the period of experiment urine secretion of mouse of experimental group is by 52.2%, more than urine secretion of mouse of control group. When we studied change of some elements in urine composition Natri increased by 15.5%, in the group which used Acorus calamus L. but Kali ion secretion decreased by 7.6%. When the dosage of Acorus calamus L. increase action activity improves more and it shows decreasing hypertension, in ECG activity positive inotrofe, shows down heart rhythm a little reducing number of contraction chronotrofec, slowing down heart inner sense transmitting negative dromotrofec. Conclusions: By our experiment it was proved that preparation Acorus calamus L. has an action increasing of bile secreting diuretic, and negative chronotrofe, positive inotrofe and negative dromotrofec effects decreasing.