In order to investigate the relationship between sex hormone receptor or glucocorticoid receptor(GR) and hepatocellular carcinoma(HCC), the contents of androgen receptor(AR) and estrogen receptor(ER) in peripheral blood lymphocytes, and GR in peripheral blood leukocytes from 13 patients with HCC and 23 healthy persons were measured by the method of radio-ligand receptor binding. The results showed that the contents of ER and AR in control group were 616?06 and 687?09 site/cell respectively: and those in HCC group were 968?20 and 2903?60 site/cell; while the content of GR in control group was 5360?1684 site/cell, and those in HCC with and without cirrhosis group were 3112?130 and 4536?201 site/cell respectively. The level of AR indicated that HCC is well correlated with AR and HCC may be an androgen-dependent tumor. The GR level is negatively correlated with the degree of liver cirrhosis. The result demonstrated that the GR contents reflect the degree of liver cirrhosis.