To explore influence of dual antiplatelet drugs on risk of upper gastrointestinal hemorrhage (UGIH) in patients with cardio‐and cerebrovascular diseases (CCVD).Methods : Clinical data of 963 CCVD pa‐tients ,who received dual antiplatelet medication ,were retrospectively analyzed .With presence of UGIH as depend‐ent variable ,clinical factors including age ,gender ,history of smoking ,drinking ,gastrointestinal hemorrhage or ul‐cer ,Helicobacter pylori (HP) infection ,combined use of proton pump inhibitor (PPI ) etc .as independent varia‐bles ;upper gastrointestinal hemorrhage condition under different clinical factors were compared .Logistic multi‐fac‐tor regression analysis was used to analyze independent risk factors of UGIH treated by dual antiplatelet drugs in CCVD patients .Results : UGIH occurred in 68 cases (7.06%) among the 963 patients .Single factor analysis indica‐ted that old age (≥65 years old) ,history of smoking ,drinking ,gastrointestinal hemorrhage or ulcer ,HP infection and no combined use of PPI lead to a significant higher incidence rate of UGIH ,P＝0.001 all ;Logistic multi‐factor regression analysis indicated that old age (≥65 years old ) ,smoking ,gastrointestinal hemorrhage or ulcer history and HP infection were independent risk factors for UGIH (OR＝1.860～5. 730 , P＜0. 05 or ＜0.01) ,while com‐bined used of PPI was its independent protective factor (OR＝0. 116 , P＝0.001).Conclusion : For CCVD patients with old age ,history of smoking ,gastrointestinal hemorrhage or ulcer and HP infection ,it is necessary to be cau‐tious for incidence of UGIH and receive combined use of PPI early ,which may help to reduce risk of UGIH .

ObjectiveTo analyze the effect of moderate intensity aerobic combined with low intensity resistance exercise on old patients with coronary heart disease and hypertension. MethodsFrom November, 2021 to May, 2022, 16 patients with coronary heart disease and hypertension in Wuhan Donghu Hospital were divided into control group (n = 8) and experimental group (n = 8). Based on the World Health Organization Family of International Classification (WHO-FICs), the exercise intervention program was constructed. The control group accepted routine treatment, and the experimental group accepted moderate intensity aerobic combined with low intensity resistance exercise in addition, for eight weeks. They were measured lung function and cardiac function with cardiopulmonary exercise test system, and assessed with Timed 'Up and Go' Test, 6-Minute Walk Distance, 2-Minute Step Test, 30-Second Sit to Stand Test and grip strength before and after intervention. ResultsThe vital capacity, forced vital capacity, forced expiratory volume in the first second, forced expiratory volume in the one second as percentage of predicted volume, peak expiratory flow and maximal voluntary ventilation improved in the experimental after intervention (|t| > 2.391, P < 0.05), and the vital capacity, force vital capacity and maximal voluntary ventilation were more in the experimental group than in the control group (|t| > 2.207, P < 0.05). Peak oxygen uptake, anaerobic subthreshold oxygen uptake, metabolic equivalents, oxygen pulse, maximum work load and exercise load time improved in the experimental group after intervention (|t| > 2.823, P < 0.05), and they all were better in the experimental group than in the control group (|t| > 2.295, P < 0.05). Systolic blood pressure improved in both the groups (|t| > 4.608, P < 0.01), and diastolic blood pressure improved in the experimental group (t = 5.964, P < 0.01); while systolic blood pressure was less in the experimental group than in the control group (t = -3.654, P < 0.01). The performances of Timed 'Up and Go' Test, 6-Minute Walk Distance, 2-Minute Step Test, 30-Second Sit to Stand Test and grip strength improved in the experimental group after intervention (|t| > 2.996, P < 0.05), and all the performances were better in the experimental group than in the control group (|t| > 2.220, P < 0.05). ConclusionThe moderate intensity aerobic combined with low resistance exercise developed based on WHO-FICs can improve the cardiac function, lung function, cardiac load and motor function of old patients with coronary heart disease and hypertension.