1.Implications of specific gene expression patterns in enamel knot in tooth development
Tae-Young KIM ; Sanjiv NEUPANE ; Yam Prasad ARYAL ; Eui-Seon LEE ; Ji-Youn KIM ; Jo-Young SUH ; Youngkyun LEE ; Wern-Joo SOHN ; Seo-Young AN ; Jung-Hong HA ; Chang-Hyeon AN ; Jae-Young KIM
International Journal of Oral Biology 2020;45(1):25-31
Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
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