1.Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats
Dong Wook LIM ; Hyejin JEON ; Minji KIM ; Minseok YOON ; Jonghoon JUNG ; Sangoh KWON ; Suengmok CHO ; Min Young UM
Nutrition Research and Practice 2020;14(6):568-579
RESULTS:
RBS supplementation improved serum triglyceride and free fatty acid levels in OVX rats. Histological analysis showed that RBS significantly attenuated hepatic fat accumulation and decreased hepatic lipid, total cholesterol, and triglyceride levels. Additionally, RBS suppressed the estrogen deficiency-induced upregulation of lipogenic genes, such as sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1, fatty acid synthase, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase 1.
CONCLUSIONS
RBS and γ-oryzanol effectively reduced lipid accumulation in a HepG2 cell hepatic steatosis model. RBS improves OVX-induced hepatic steatosis by regulating the SREBP1-mediated activation of lipogenic genes, suggesting the benefits of RBS in preventing fatty liver in postmenopausal women.
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