PURPOSE: Acute appendicitis has atypical clinical findings that make accurate preoperative diagnosis difficult. The aim of this study was to investigate the usefulness of laboratory analyses, especially total leukocyte count (WBC) and neutrophil count, C-reactive protein (CRP) in the diagnosis of acute appendicitis. METHODS: Sixty-nine patients who visited to the Department of Surgery, Sangju St. Mary's hospital with the diagnosis suspected acute appendicitis were studied. WBC, neutrophil count, CRP, and erythrocyte sedimentation rate (ESR) were analysed. Surgery for acute appendicitis was performed in fifty-four patients. According to histopathological findings of the appendix, the patients were divided into four groups: complicated (20 patients with perforated & gangrenous type), suppurative (9 patients), phlegmonous (25 patients), and normal (15 patients). The sensitivity and specificity of the laboratory tests in the diagnosis of acute appendicitis were calculated. RESULTS: The sensitivity of WBC>10, 000/mm3, neutrophil count>70% or >7, 000/mm3, and CRP>12 mg/L in acute appendicitis was 68.5%, 85.1%, and 74.0%, and the specificity was 86.0%, 73.3%, and 80.0% respectively. The combination of neutrophil count or CRP was 94.4% sensitivity. The severity of appendicitis had positive relationship with WBC, neutrophil count, and CRP (P=0.0001, P<0.0001, and P= 0.0014, respectively). The appendicitis and normal groups were significantly different in WBC, neutrophil count, and CRP (P<0.05). CONCLUSION: WBC, neutrophil count, and CRP have diagnostic value among the myriad causes of right lower quadrant abdominal pain and show a positive relationship with the severity of appendicitis.
Abdominal Pain ; Appendicitis* ; Appendix ; Blood Sedimentation ; C-Reactive Protein ; Cellulitis ; Diagnosis ; Gyeongsangbuk-do ; Humans ; Leukocyte Count ; Neutrophils ; Sensitivity and Specificity

BACKGROUND: Enlarged skin pore is a type of serious cosmetic defect for many women. However, the mechanisms underlying the skin pores remain unclear. Currently, several treatment methods are in practice for enlarged skin pores and the most common among those are topical alpha-hydroxy acid, retinoid and chemical peel. OBJECTIVE: To evaluate the patients' knowledge, awareness and method of the treatment of the skin pores. METHODS: Analysis of the interview results and questionnaire responses from 256 individuals, who did not having any history of medical disease. RESULTS: The number of patients who think that they have enlarged skin pores was 225 (88%). The most common site was around the nose (48%). Enlarged skin pores are thought to be caused by several factors; seborrhea (38%), after removal of sebum (35%) and acne (30%), and common dissatisfactions with enlarged skin pores were visible blackheads and older looks. Patients receive skin care for enlarged skin pores via various remedies, but only 11% actually received dermatologic procedure. CONCLUSION: High proportion of the population has great concerns regarding their enlarged skin pores, but lack proper treatment. Enlarged skin pores lead to one's dissatisfaction, such as blackheads and older look. Thus, we should investigate the insight on skin pores and offer beneficial treatments for concerned patients.
Acne Vulgaris ; Cosmetics ; Dermatitis, Seborrheic ; Female ; Humans ; Nose ; Sebum ; Skin ; Skin Care ; Surveys and Questionnaires

BACKGROUND: Striae distensae is a common skin condition that can happen to everyone. Most cases do not have serious problems, but those who are affected may suffer from strong cosmetic stress. There was an epidemiologic study of striae distensae in Korean adolescents. Up to now, variable treatment modalities have been tried including topical application of tretinoin and light-based therapy using pulsed dye lasers or fractional lasers. OBJECTIVE: To evaluate the prevalence of striae distensae in Korean women and estimate their understanding. METHODS: We carried out a survey targeting 256 healthy female adults without a history of medical disease and analyzed the results. RESULTS: The number of patients with striae distensae were 219 (86.0%). Striae distensae was mostly seen at the thigh and calf (84.0%) and longitudinal formed striae, with their long axis parallel to the lines of skin tension, was the most frequent shape (44.0%). The most common color of the striae distensae was white (56.0%) and 78% of patients had experienced this before adulthood. Striae distensae is caused by two major factors, overweight (70.0%) and growth spurts (24.0%), and 244 patients (76.0%) replied that they felt uncomfortable because of this disorder. Nineteen patients (8.6%) with striae distensae had gone through treatment. Among them, 11 (5.0%) had technical treatment in dermatologic clinics such as, pulse dye laser, fractional laser, and chemical peeling. Eight patients (3.7%) were treated with folk remedies including moxibustion and acupuncture therapy. However, 154 patients (71%) responded that they wanted treatment for the striae lesion, and 93 patients (43%) have great intention to treatment. CONCLUSION: A lot of patients are still suffering from striae distensae, but so far there is no appropriate treatment. The biggest problem is that there is very little understanding of striae distensae. Patients should be aware of their striae distensae and we should provide appropriate treatment.
Acupuncture Therapy ; Adolescent ; Adult ; Axis, Cervical Vertebra ; Cosmetics ; Epidemiologic Studies ; Female ; Humans ; Intention ; Lasers, Dye ; Medicine, Traditional ; Moxibustion ; Overweight ; Prevalence ; Skin ; Stress, Psychological ; Striae Distensae ; Thigh ; Tretinoin

Background: Digital panoramic dental X-ray equipment (PDX) is frequently used by patients and dental workers for diagnosis andexamination in dental institutions; however, infection control has not been properly implemented. Therefore, in this study, we aimed to systematically review the potential risk of cross-infection in the dental environment by investigating the contamination level of general aerobic bacteria and Staphylococcus aureus, which are important in hospital infections, in PDX areas that people mainly contact. Methods: This survey was conducted from March to May 2023 and covered one general hospital, three dental hospitals, and ninedental clinics equipped with PDX. Bacteria samples were collected from the left-handle, right-handle, forehead support, and head side support as the patient’s contact areas, as well as the X-ray exposure switch and left-click mouse button as the dental hygienist’s contact areas of the PDX. The collected bacteria were spread on Petrifilm, and colonies formed after 48 hours of culture were counted. Results: General aerobic bacteria and S. aureus were detected in all areas investigated. Significant differences in bacterial counts between different regions of the PDX were observed in both groups (p＜0.001). The detection rates of general aerobic bacteria (p＜0.001) and S. aureus (p＜0.001) were significantly higher in the contact areas of patients than those of dental hygienists. A positive correlation was observed between the forehead and the temple region in terms of general aerobic bacteria and S. aureus detection (r=1) (p＜0.01). Conclusion Taken together, the presence of many bacteria, including S. aureus, detected in PDX indicates that PDX has a potential cross-infection risk. Our results therefore highlight the need for the development of appropriate disinfection protocols for reusable medical devices such as PDX and periodic infection prevention training for hospital-related workers, including dental hygienists.

The aim of this study was to examine the geriatric status, oral health, and oral health related quality of life of stroke patients hospitalized at a rehabilitatio ward and assess the relationships among these factors. A total of 78 stroke patients participated in this cross-sectional study. The following oral examinations were performed by a dentist and dental hygienist: Decayed, Missing, Filled Teeth, gingival, debris, calculus, and community periodontal index (CPI). The patients' sociodemographic and geriatric status were evaluated using the Barthel index and a mini-mental state examine (MMSE) according to their medical record and a questionnaire survey. Oral health related quality of life was assessed using the Oral Health Impact Profile (OHIP)-14 questionnaire. Except for three participants, most stroke patients had a gingival index of 2 or more, which means probing results in bleeding gums. Additionally, 53.8% of participants had a CPI code of 3 or 4, which indicates a probing depth of 4 mm or more. CPI index was significantly related to debris, calculus, and gingival index. The OHIP-14 score significantly related to the Barthel index and MMSE (p<0.05). The oral health of stroke patients in the rehabilitation ward was relatively poor and related to poor oral hygiene. Oral health related quality of life was related not to oral health but to geriatric status significantly.
Calculi ; Cross-Sectional Studies ; Dental Hygienists ; Dentists ; Diagnosis, Oral ; Gingiva ; Hemorrhage ; Humans ; Medical Records ; Oral Health* ; Oral Hygiene ; Periodontal Index ; Pilot Projects* ; Quality of Life* ; Rehabilitation* ; Stroke* ; Tooth

Objectives: This study aimed to identify the relationship between mental health problems and oral health in older adults. Methods: The participants of this study were older adults aged 65 years or older. The study used the data of 16,489 people who responded to the 7th Korean National Health and Nutrition Examination Survey. Multiple logistic regression analysis was performed to evaluate the effect of depression on the frequency of tooth brushing when confounding factors such as income quintile and smoking were considered. Statistical software, SAS 9.4 ver. (SAS Institute, Cary, NC) was used. Results: Depressed older adult participants were 1.3 times more likely to brush their teeth less than three times a day than non-depressed participants, which was statistically significant. In women with depression, the odds of brushing their teeth less than three times a day were 1.5 times higher than those without depression, which was statistically significant. Conclusions Depression in older adults is correlated with the number of tooth brushes per day. Moreover, depression in women affects their number of tooth brushes.

In 2010, disease symptoms, including necrotic lesions on stems and leaves with circular yellow-brown or irregular brown color patches, were observed on cool-season turfgrass at golf courses (OHCC) and the Daegu University research farm in Gyeongbuk, Korea. We isolated the causal agent and identified it as Waitea circinata var. zeae by morphological characterization and molecular analysis. To the best of our knowledge, this is the first report of brown patch caused by W. circinata var. zeae on cool-season turfgrass in Korea.
Agriculture ; Daegu ; Golf ; Gyeongsangbuk-do ; Korea* ; Seasons* ; Virulence

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is one of the leading causes of cancer-related deaths worldwide. Imatinib and GNF-5 are breakpoint cluster region-Abelson murine leukemia tyrosine kinase inhibitors which have been approved for the treatment of chronic myeloid leukemia and various solid tumors. However, the effect and underlying mechanisms of imatinib and GNF-5 in HCC remain poorly defined. In this study, we investigated the anticancer activity and underlying mechanisms of imatinib and GNF-5 in HepG2 human hepatocarcinoma cells. Cell proliferation and anchorage-independent colony formation assays were done to evaluate the effects of imatinib and GNF-5 on the growth of HepG2 cells. The cell cycle was assessed by flow cytometry and verified by immunoblot analysis. Gene overexpression and knockdown assays were conducted to evaluate the function of S-phase kinase-associated protein 2 (Skp2). Imatinib and GNF-5 significantly inhibited the growth of HepG2 cells. Imatinib and GNF-5 induced G0/G1 phase cell cycle arrest by downregulating Skp2 and upregulating p27 and p21. Overexpression of Skp2 reduced the effect of imatinib and GNF-5 on HepG2 cells. Knockdown of Skp2 suppressed the proliferation and induced G0/ G1 phase arrest. Furthermore, knockdown of Skp2 enhanced the effect of imatinib and GNF-5 on growth of HepG2 cells. In conclusion, imatinib and GNF-5 effectively suppress HepG2 cell growth by inhibiting Skp2 expression. Skp2 promotes the cell proliferation and reverse G0/G1 phase cell cycle arrest and it represents a potential therapeutic target for HCC treatment.

Anaplasma species are obligate intracellular pathogens that can cause tick-borne diseases in mammalian hosts. To date, very few studies of their occurrence in Korean native goats (Capra aegagrus hircus) have been reported. In the present study, we investigated Anaplasma infection of Korean native goats on Jeju Island, Republic of Korea, and performed phylogenetic analysis based on the 16S rRNA gene sequences. Our results showed that Anaplasma infection was found mostly in adult female goats. The phylogenetic tree revealed that the 7 sequences identified in Korean native goats could belong to Anaplasma sp. and were distinct from A. marginale, A. centrale, and A. ovis. The results indicated that the sequences identified to belong to Anaplasma were closely related to sequences isolated from goats in China and were clustered within the same group. To our knowledge, this is the first study to detect Anaplasma sp. infection in Korean native goats.
Anaplasma/classification/genetics/*isolation & purification ; Anaplasmosis/*microbiology ; Animals ; Female ; Goat Diseases/*microbiology ; Goats ; Islands ; Male ; Molecular Sequence Data ; Phylogeny ; Republic of Korea

Bovine viral diarrhea virus (BVDV), which is prevalent worldwide, is one of the most important viral pathogens and causes substantial economic loss to the livestock industry. Despite its importance, BVDV is largely unnoticed in the Republic of Korea (ROK). In this study, we report the case of a steer with BVDV that died suddenly due to severe enteritis. Two 1-year-old Korean indigenous cattle in the same herd presented severe hemorrhagic diarrhea. Case 1 had severe dehydration and died after 3 days, whereas case 2 had anorexia, depression, and severe diarrhea with mucus and blood. Only case 2 was necropsied, and BVDV2a was detected in the tissues of its alimentary tract. Gross lesions, including erosion, ulceration, and extensive hemorrhage, were observed in the digestive tract mucosa. Immunohistochemistry revealed marked positive staining for BVDV2a antigen in the large intestine. This report describes the first case of hemorrhagic disease caused by acute BVDV2a infection, which is characterized by high mortality in Korean indigenous cattle. This study will help establish vaccination and control strategies for BVDV in the ROK.