1.A biomechanical Comparison of Different Fixation Techniques on Intercondylar Eminence Fractures of Tibia.
Dongmin SHIN ; Hongmoon SHON ; Sangho HA
Journal of the Korean Knee Society 1998;10(2):184-189
Methods of internal fixation for displaced intercondylar eminence fractures of tibia are percutaneous pinning, pull-out knot with wire or nylon and screw fixation. We tried experimental tensile test on four different fixation methods with 60 fresh pig knees. The results were as follows. 1. In our experimental study, the maximum tensile strength(M.T.S.) was recorded average 73.49N in the group of percutaneous pinning, 133.01N in Ethilon used group, 198.01N in wire used group and 275.05N in screw fixed group. 2. The group of percutaneous pinning with K-wires showed the lowest value of M.T.S., therefore, this method of fixation must be discarded. 3. The M.T.S of pull-out knot tie was about twice as high as that of percutaneous pinning. But the method of knotting should be improved because of the failure around the knot. 4. The group of screw fixation showed the highest value of M.T.S., but this method of fixation has some problems, like as arthrotomy or difficulty of removal of hardware.
Knee
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Nylons
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Tibia*
2.Morphologic Analysis of Cytomegalovirus Infected Cells in Bronchial Washing Cytology: Comparison of Liquid-Based Preparation and Conventional Smear.
Jae Yeon SEOK ; Jungsuk AN ; Seung Yeon HA ; Dong Hae CHUNG ; Sangho LEE ; Hyunchul KIM
Journal of Pathology and Translational Medicine 2016;50(2):147-154
BACKGROUND: The cytopathic effects of cytomegalovirus (CMV) infection have been well described since the virus was first reported; however, the morphology of CMV infection has not been clearly studied. We examined the difference in detailed cytologic findings in bronchial washing cytology between liquid-based and conventionally prepared smears. METHODS: Bronchial washing cytology was processed using either the conventional preparation (CP) or liquid-based preparation (LBP). Sixty-nine cells with typical cytopathic effects of CMV infection were detected on CP slides and 18 cells on LBP slides. Using the image analyzer, area, circumference, major axis, and minor axis of the cytoplasm, nucleus, and intranuclear inclusion were measured in singly scattered CMV-infected cells, and histiocytes were used as a control. RESULTS: The mean cytoplasmic area of CMV-infected cells was 1.47 times larger than that of histiocytes in CP and 2.92 times larger in LBP (p<.05). The mean nuclear area of CMV-infected cells was 2.61 times larger than that of histiocytes in CP and 4.25 times larger in LBP (p<.05). The nucleus to cytoplasm ratio and intranuclear inclusion to cytoplasm ratio of the mean area, circumference, major axis, and minor axis in CP were larger than those in LBP (p<.05). CONCLUSIONS: The sizes of cytoplasm, nucleus, and intranuclear inclusion were larger in LBP than in CP, indicating that CMV-infected cells are easily detectable in LBP. However, the nucleus-to-cytoplasm ratio was larger in CP, suggesting that differentiation from malignancy or regenerative atypia requires caution in CP.
Axis, Cervical Vertebra
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Cytomegalovirus*
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Cytoplasm
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Histiocytes
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Intranuclear Inclusion Bodies
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Lung
3.Eosinophilic granulomatosis with polyangiitis accompanied by rapidly progressive glomerulonephritis.
Sojeong KIM ; Sang Min LEE ; Young Sup SHIM ; Jeong Yeal AHN ; Sangho LEE ; Seung Heon HA ; Sang Pyo LEE
Allergy, Asthma & Respiratory Disease 2016;4(1):70-73
Eosinophilic granulomatosis with polyangitis (EGPA) should be considered in asthmatic patients who present with severe systemic symptoms and eosinophilia. Progressive renal insufficiency can occur during the acute phase of EGPA accompanied by renovascular involvement. A 58-year-old man visited local clinic with complaints of malaise, weight loss, fever, and dyspnea. Eosinophilia was revealed in peripheral blood. Pulmonary function tests were carried out, which yielded decreased lung function with positive bronchodilator response. Kidney and skin biopsies were performed, and histological examination showed acute necrotizing crescentic glomerulonephritis and leukoclastic vasculitis in the skin, which led to a diagnosis of EGPA (Churg-Strauss syndrome) associated with rapidly progressive glomerulonephritis. The patient received pulse steroid therapy with parenteral methylprednisolone, followed by oral prednisolone. Clinical and laboratory findings improved dramatically, and remission was attained rapidly. The patient continued to be in remission for 5 months. Prompt and aggressive treatment with systemic corticosteroids is mandatory to control disease activity and to achieve remission.
Adrenal Cortex Hormones
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Biopsy
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Churg-Strauss Syndrome
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Diagnosis
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Dyspnea
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Eosinophilia
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Eosinophils*
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Fever
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Glomerulonephritis*
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Humans
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Kidney
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Lung
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Methylprednisolone
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Middle Aged
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Prednisolone
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Renal Insufficiency
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Respiratory Function Tests
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Skin
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Vasculitis
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Weight Loss
4.Bilateral Stafne Bone Cavity in the Anterior Mandible with Heterotopic Salivary Gland Tissue: A Case Report.
Hyunchul KIM ; Jae Yeon SEOK ; Sangho LEE ; Jungsuk AN ; Na Rae KIM ; Dong Hae CHUNG ; Hyun Yee CHO ; Seung Yeon HA
Korean Journal of Pathology 2014;48(3):248-249
No abstract available.
Mandible*
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Salivary Glands*
5.The Analysis of Induction Chemotherapy Using Docetaxel and Platinum in Treatment of Hypopharyngeal Carcinoma.
Jongseung KIM ; Kyengsuk LEE ; Byungeon HWANG ; Sangho LIM ; Sunho RYU ; Ilwoo HA ; Eun Jung LEE ; Kihwan HONG ; Yunsu YANG
Korean Journal of Otolaryngology - Head and Neck Surgery 2010;53(11):706-711
BACKGROUND AND OBJECTIVES: The aim of this study was to determine the efficacy of induction chemotherapy with docetaxel and platinum in patients with hypopharyngeal carcinoma. SUBJECTS AND METHOD: The medical records of 66 patients who were diagnosed with hypopharyngeal carcinoma at our department from January 1996 to December 2008 were reviewed and retrospectively analyzed. The patients were divided into four groups according to treatment method: Group I was treated with radiation and induction chemotherapy consist of docetaxel and platinum (27); Group II was treated with surgery and induction chemotherapy consist of docetaxel and platinum (28), Group III was treated with radiation and induction chemotherapy consist of 5-FU and platinum (9) and Group IV was treated with surgery and induction chemotherapy consist of 5-FU and platinum (2). A total of 186 chemotherapy cycles were administered to patients and most of the patients received at least 2 cycles. RESULTS: The T-stage distribution at diagnosis was 7.5%, 42.4%, 28.8%, and 21.2% for T1, T2, T3, and T4, respectively. The N-stage distribution at diagnosis was 48.5%, 22.7%, 10.6%, 15.2%, and 9.1% for N0, N1, N2a, N2b, and N2c, respectively. The overall 3-year survival rate was 44.3%. The 3-year survival rate of each group was 42.6% in Group I, 54.8% in Group II, and 11.1% in Group III. There was no significant difference in survival between Groups I and III (p=0.074). There was no difference in sex, age, and N stage for 3-year survival rate. CONCLUSION: Although any valid conclusions could not be drawn because of the small number of patients examined here, induction chemotherapy consisting of docetaxel and platinum may improve the outcome of patients with hypopharyngeal carcinoma.
Fluorouracil
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Humans
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Induction Chemotherapy
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Medical Records
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Platinum
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Retrospective Studies
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Survival Rate
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Taxoids
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Treatment Outcome
6.Comparison of papanicolaou smear and human papillomavirus (HPV) test as cervical screening tools: can we rely on HPV test alone as a screening method? An 11-year retrospective experience at a single institution
Myunghee KANG ; Seung Yeon HA ; Hyun Yee CHO ; Dong Hae CHUNG ; Na Rae KIM ; Jungsuk AN ; Sangho LEE ; Jae Yeon SEOK ; Juhyeon JEONG
Journal of Pathology and Translational Medicine 2020;54(1):112-118
Background:
The decrease in incidence of cervical dysplasia and carcinoma has not been as dramatic as expected with the development of improved research tools and test methods. The human papillomavirus (HPV) test alone has been suggested for screening in some countries. The National Cancer Screening Project in Korea has applied Papanicolaou smears (Pap smears) as the screening method for cervical dysplasia and carcinoma. We evaluated the value of Pap smear and HPV testing as diagnostic screening tools in a single institution.
Methods:
Patients co-tested with HPV test and Pap smear simultaneously or within one month of each other were included in this study. Patients with only punch biopsy results were excluded because of sampling errors. A total of 999 cases were included, and the collected reports encompassed results of smear cytology, HPV subtypes, and histologic examinations.
Results:
Sensitivity and specificity of detecting high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma (SCC) were higher for Pap smears than for HPV tests (sensitivity, 97.14%; specificity, 85.58% for Pap smears; sensitivity, 88.32%; specificity, 54.92% for HPV tests). HPV tests and Pap smears did not differ greatly in detection of low-grade squamous intraepithelial lesion (85.35% for HPV test, 80.31% for Pap smears). When atypical glandular cells were noted on Pap smears, the likelihood for histologic diagnosis of adenocarcinoma following Pap smear was higher than that of high-risk HPV test results (18.8 and 1.53, respectively).
Conclusions
Pap smears were more useful than HPV tests in the diagnosis of HSIL, SCC, and glandular lesions.
7.Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields
Yong Jun CHOI ; Min Jae LEE ; Min Kwang BYUN ; Sangho PARK ; Jimyung PARK ; Dongil PARK ; Sang-Hoon KIM ; Youngsam KIM ; Seong Yong LIM ; Kwang Ha YOO ; Ki Suck JUNG ; Hye Jung PARK
Tuberculosis and Respiratory Diseases 2024;87(1):65-79
Background:
Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated.
Methods:
We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively.
Results:
Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strong positive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specific version of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725, p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078, p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forced expiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significant correlation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1 alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin (ρ=0.4445 and p=0.0017).
Conclusion
Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed.
8.Association of decreased estimated glomerular filtration rate with lung cancer risk in the Korean population
Soonsu SHIN ; Min-Ho KIM ; Chang-Mo OH ; Hyejin CHUN ; Eunhee HA ; Hyo Choon LEE ; Seong Ho MOON ; Dong-Young LEE ; Dosang CHO ; Sangho LEE ; Min Hyung JUNG ; Jae-Hong RYOO
Epidemiology and Health 2024;46(1):e2024041-
OBJECTIVES:
Inconsistent results are available regarding the association between low estimated glomerular filtration rate (eGFR) and lung cancer risk. We aimed to explore the risk of lung cancer according to eGFR category in the Korean population.
METHODS:
We included 358,293 adults who underwent health checkups between 2009 and 2010, utilizing data from the National Health Insurance Service-National Sample Cohort. Participants were categorized into 3 groups based on their baseline eGFR, as determined using the Chronic Kidney Disease Epidemiology Collaboration equation: group 1 (eGFR ≥90 mL/min/1.73 m2), group 2 (eGFR ≥60 to <90 mL/min/1.73 m2), and group 3 (eGFR <60 mL/min/1.73 m2). Incidences of lung cancer were identified using the corresponding codes from the International Classification of Diseases, 10th revision. Multivariate Cox proportional hazard models were employed to calculate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for lung cancer incidence up to 2019.
RESULTS:
In multivariate analysis, group 2 exhibited a 26% higher risk of developing lung cancer than group 1 (HR, 1.26; 95% CI, 1.19 to 1.35). Furthermore, group 3 demonstrated a 72% elevated risk of lung cancer relative to group 1 (HR, 1.72; 95% CI, 1.58 to 1.89). Among participants with dipstick proteinuria of 2+ or greater, group 3 faced a significantly higher risk of lung cancer than group 1 (HR, 2.93; 95% CI, 1.37 to 6.24).
CONCLUSIONS
Low eGFR was significantly associated with increased lung cancer risk within the Korean population. A particularly robust association was observed in individuals with severe proteinuria, emphasizing the need for further investigation.
9.Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction,and angina pectoris in Korean population
Sung Keun PARK ; Ju Young JUNG ; Min-Ho KIM ; Chang-Mo OH ; Eunhee HA ; Eun Hye YANG ; Hyo Choon LEE ; Soonsu SHIN ; Woo Yeon HWANG ; Sangho LEE ; So Youn SHIN ; Jae-Hong RYOO
Epidemiology and Health 2023;45(1):e2023088-
OBJECTIVES:
Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease.
METHODS:
The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative → negative; resolved: proteinuria ≥1+ → negative; incident: negative → proteinuria ≥1+; persistent: proteinuria ≥1+ → proteinuria ≥1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris.
RESULTS:
The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]).
CONCLUSIONS
Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.
10.Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis
Myunghee KANG ; Dong Hae CHUNG ; Na Rae KIM ; Hyun Yee CHO ; Seung Yeon HA ; Sangho LEE ; Jungsuk AN ; Jae Yeon SEOK ; Gie Taek YIE ; Chan Jong YOO ; Sang Gu LEE ; Eun Young KIM ; Woo Kyung KIM ; Seong SON ; Sun Jin SYM ; Dong Bok SHIN ; Hee Young HWANG ; Eung Yeop KIM ; Kyu Chan LEE
Journal of Pathology and Translational Medicine 2019;53(2):104-111
BACKGROUND: Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate the diagnostic value of cytology in frozen diagnoses of CNS neoplasms. METHODS: Cases were selected from patients undergoing both frozen cytology and frozen sections. Diagnostic accuracy was evaluated. RESULTS: Four hundred and fifty-four cases were included in this retrospective single-center review study covering a span of 10 years. Five discrepant cases (1.1%) were found after excluding 53 deferred cases (31 cases of tentative diagnosis, 22 cases of inadequate frozen sampling). A total of 346 cases of complete concordance and 50 cases of partial concordance were classified as not discordant cases in the present study. Diagnostic accuracy of intraoperative frozen diagnosis was 87.2%, and the accuracy was 98.8% after excluding deferred cases. Discrepancies between frozen and permanent diagnoses (n = 5, 1.1%) were found in cases of nonrepresentative sampling (n = 2) and misinterpretation (n = 3). High concordance was observed more frequently in meningeal tumors (97/98, 99%), metastatic brain tumors (51/52, 98.1%), pituitary adenomas (86/89, 96.6%), schwannomas (45/47, 95.8%), high-grade astrocytic tumors (47/58, 81%), low grade astrocytic tumors (10/13, 76.9%), non-neoplastic lesions (23/36, 63.9%), in decreasing frequency. CONCLUSIONS: Using intraoperative cytology and frozen sections of CNS tumors is a highly accurate diagnostic ancillary method, providing subtyping of CNS neoplasms, especially in frequently encountered entities.
Brain Neoplasms
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Central Nervous System Neoplasms
;
Central Nervous System
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Cytogenetics
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Diagnosis
;
Frozen Sections
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Humans
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Meningeal Neoplasms
;
Methods
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Neurilemmoma
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Pituitary Neoplasms
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Retrospective Studies