STUDY DESIGN: Retrospective study. PURPOSE: To highlight risk factors, recurrence patterns and multimodal treatment in management of recurrent giant cell tumors (GCTs). OVERVIEW OF LITERATURE: GCTs of the spine are rare and challenging entities. Recurrences are very common and warrant complex management to prevent multiple recurrences. Gross total resection is preferred over subtotal procedures to prevent recurrences. However, resection is associated with morbidity and mortality. Proper understanding of risk factors and a high index of suspicion helps to spot recurrences early and aids in subsequent management. METHODS: Ten patients (six females, four males) with recurrent GCTs underwent 17 interventions. There were six lesions in the thoracic spine, two in the cervical spine and two in the lumbar spine. Recurrences were managed with preoperative digital subtraction embolization, intralesional curettage and postoperative radiotherapy. RESULTS: The average age at intervention was 31.3 years. The average duration of recurrence in patients following index surgery in a tertiary care hospital and surgery elsewhere was 7.3 years and was 40 months, respectively. The minimum recurrence-free interval after the last recurrent surgery was 10 years. CONCLUSIONS: Our study reports the largest recurrence-free interval for GCTs. Recurrent GCTs are challenging entities. Understanding of risk factors and meticulous planning is required to prevent recurrences. Intralesional surgery could be a safer and effective modality in managing recurrences.
Combined Modality Therapy ; Curettage ; Female ; Giant Cell Tumors* ; Giant Cells* ; Humans ; Mortality ; Radiotherapy ; Recurrence* ; Retrospective Studies ; Risk Factors* ; Spine ; Tertiary Healthcare

STUDY DESIGN: Prospective study. PURPOSE: We present a series of 50 patients with tuberculous cord compression who were offered systematic non-surgical treatment, and thereby, the author proposes that clinico-radiological soft tissue cord compression is not an emergency indication for surgery. OVERVIEW OF LITERATURE: Spinal cord compression whether clinical or radiological has usually been believed to be an indication for emergency surgery in spinal tuberculosis. METHODS: Fifty adults were prospectively studied at our clinic for spinal cord compression due to tuberculous spondylitis, between May 1993 and July 2002. The inclusion criteria were cases with clinical and/or radiological evidence of cord compression (documented soft tissue effacement of the cord with complete obliteration of the thecal sac at that level on magnetic resonance imaging scan). Exclusion criteria were lesions below the conus level, presence of bony compression, severe or progressive neurological deficit ( Adult ; Child ; Conus Snail ; Emergencies ; Evoked Potentials, Somatosensory ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Neurology ; Prospective Studies ; Spinal Cord Compression ; Spondylitis ; Tuberculosis* ; Tuberculosis, Spinal